Diphenhydramine Hydrochloride hmoovyog diphenhydramine-zoo li tshuaj, thiab nws cov tshuaj npe yog 2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride. Nws yog dawb crystalline hmoov los yog flake crystal, tasteless, tsw, tsis-flammable, nrog tsawg saturated vapor siab, yooj yim soluble nyob rau hauv dej thiab ethanol, me ntsis soluble nyob rau hauv chloroform thiab benzene, yuav luag insoluble nyob rau hauv ether. Nws yog ib tug compound uas yog heev soluble nyob rau hauv dej. Ntawm qhov kub thiab txias, nws tuaj yeem tsim cov kua dej ntshiab nrog dej, thiab nws cov solubility yuav nce ntxiv thaum kub nce. Tus nqi pH yog nyob nruab nrab ntawm 4.0-5.5, uas txhais tau hais tias nws yog ib qho tsis muaj zog acidic. Nws tuaj yeem siv los ua cov khoom xyaw hauv cov tshuaj xws li kev ua xua. Nws yog ib qho tshuaj diphenhydramine, uas tuaj yeem siv los kho cov kab mob ua xua xws li ua xua rhinitis, hay fever, zaub mov tsis haum, thiab lwm yam. Nws kuj tuaj yeem siv los txo cov tsos mob xws li hnoos, sedative pw tsaug zog, anticholinergic nyhuv, thiab kev tiv thaiv kev mob kev nkeeg.
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Diphenhydramine Hydrochloride hmoovyog ib qho tshuaj diphenhydramine, uas muaj ntau yam tshuaj muaj txiaj ntsig thiab tuaj yeem siv los kho ntau yam kab mob thiab cov tsos mob.
1. Kev kho cov tsos mob ua xua: Diphenhydramine Hydrochloride yog ib qho tshuaj antihistamine uas tuaj yeem tiv thaiv kev tso tawm thiab kev ua ntawm histamine, yog li txo cov tsos mob tshwm sim los ntawm kev tsis haum tshuaj, xws li txham, qhov ntswg congestion, los ntswg qhov ntswg, khaus tawv nqaij, thiab lwm yam. Yog li ntawd, Diphenhydramine Hydrochloride yog dav siv nyob rau hauv kev kho mob ntawm allergic rhinitis, hay. ua npaws, zaub mov tsis haum thiab lwm yam kab mob tsis haum.
2. Txo cov hnoos qeev: Diphenhydramine Hydrochloride muaj cov nyhuv antitussive, nws tuaj yeem txo qhov kev zoo siab ntawm lub hauv paus paj hlwb thiab txo qhov hnoos. Yog li ntawd, Diphenhydramine Hydrochloride kuj tseem siv tau los kho hnoos qhuav, mob ntsws ntsws thiab lwm yam kab mob.
3. Sedation thiab pw tsaug zog: Diphenhydramine Hydrochloride muaj cov nyhuv sedative, uas tuaj yeem cuam tshuam rau hauv nruab nrab lub paj hlwb thiab txo cov excitability ntawm neurons, yog li ua rau sedative nyhuv. Yog li ntawd, Diphenhydramine Hydrochloride kuj yog siv los kho insomnia, ntxhov siab vim thiab lwm yam kab mob.
4. Cov nyhuv Anticholinergic: Diphenhydramine Hydrochloride muaj cov nyhuv anticholinergic, uas tuaj yeem tiv thaiv kev ua ntawm acetylcholine thiab khi rau histamine receptors, yog li tsim cov nyhuv antiallergic. Cov tshuaj siv tshuaj no ua rau Diphenhydramine Hydrochloride kuj tseem siv los kho cov kab mob xws li mob plab thiab mob hlab ntsha tawg.
5. Analgesic: Diphenhydramine Hydrochloride muaj cov nyhuv analgesic me ntsis thiab tuaj yeem siv los txo qhov mob me. Txawm li cas los xij, vim nws cov nyhuv analgesic tsis muaj zog, nws feem ntau tsis yog siv ib leeg los ua tshuaj loog, tab sis ua ke nrog lwm cov tshuaj.
6. Kev tiv thaiv kev mob nkeeg: Diphenhydramine Hydrochloride kuj tseem tuaj yeem siv los tiv thaiv kev mob nkeeg, xws li seasickness thiab airsickness. Nws cov nyhuv sedative thiab antiallergic tuaj yeem txo cov tsos mob xws li xeev siab thiab ntuav los ntawm kev mob tshwm sim.
7. Antidepressant: Qee cov kev tshawb fawb nyob rau xyoo tas los no kuj tau pom tias Diphenhydramine Hydrochloride muaj qee yam tshuaj tiv thaiv kev nyuaj siab thiab tuaj yeem txo cov tsos mob ntawm kev nyuaj siab rau qee yam. Txawm li cas los xij, cov tshuaj tsis yog cov tshuaj antidepressant tseem ceeb thiab feem ntau siv los ua kev kho mob ntxiv.
Diphenhydramine Hydrochloride hmoovyog ib qho tshuaj diphenhydramine tseem hu ua HCl-DPH. Nws tuaj yeem siv los kho cov kab mob rhinitis, hay fever, zaub mov ua xua thiab lwm yam kab mob ua xua, thiab nws kuj tuaj yeem siv los txo qhov hnoos, sedative pw tsaug zog, cov nyhuv anticholinergic, thiab tiv thaiv kev mob nkeeg. Kab lus no yuav qhia tag nrho cov txheej txheem synthesis ntawm Diphenhydramine Hydrochloride.
Benzoyl peroxide-sodium nitrite method: Txoj kev no yog ib txoj hauv kev los npaj Diphenhydramine Hydrochloride. Ua ntej, benzoyl peroxide (C6H5COOC6H5) yog reacted nrog sodium nitrite los tsim 2,2-diphenylethane-1-nitrogen dioxide (C6H5CH2)2N2O). Tom qab ntawd, qhov nruab nrab no ntxiv rau hauv HCl tov, thiab sodium sulfite ntxiv ntxiv rau kev txo kom tau Diphenhydramine Hydrochloride. Lub mechanism ntawm qhov tshuaj tiv thaiv yog raws li nram no:
2C6H5COOC6H5+ 2NWS2+ 4HCl → 2(C6H5CH2)2N2·2HCl + 4NaCl + 2H2O
2(C6H5CH2)2N2O·2HCl + Na2YOG3 → 2C17H21NO·HCl + Na2YOG4 + H2O
Aniline-phenylacetonitrile txoj kev: Txoj kev no muaj cov nqi raw khoom tsawg thiab cov tshuaj tiv thaiv yooj yim, thiab yog ib txoj kev siv nyiaj txiag thiab siv tau zoo. Ua ntej, aniline thiab phenylacetonitrile yog cua sov thiab ua rau lub cev ua kom muaj -phenyl-N-phenylacetonitrile methylacetamide. Qhov nruab nrab yog tom qab ntawd raug txo qis hydrogenation kom tau txais Diphenhydramine Hydrochloride. Lub mechanism ntawm qhov tshuaj tiv thaiv yog raws li nram no:
C6H5NH2 + C6H5CH2CN → HC(C6H5)2CH2NHCOCH3
HC (C6H5)2CH2NHCOCH3 + H2 → C17H21NO · HCl
Methylene xiav- txoj kev aniline: Txoj kev no siv methylene xiav thiab aniline ua cov khoom siv raw, thiab npaj Diphenhydramine Hydrochloride los ntawm cov tshuaj tiv thaiv cua sov, acidolysis thiab lwm cov kauj ruam. Lub mechanism ntawm qhov tshuaj tiv thaiv yog raws li nram no:
C10H8N2S·2HCl + 2C6H5NH2→ HC(C6H5)2CH2NHCSNHC6H5 + 2H2O
HC (C6H5)2CH2NHCSNHC6H5+ 2HCl → C17H21NO·HCl + C6H5NH2 + C10H8N2S
1-phenyl-2-(dimethylamino)ethylene-aniline txoj kev: txoj kev no siv 1-phenyl-2-(dimethylamino)ethylene thiab aniline ua raw cov ntaub ntawv, thiab tau txais Diphenhydramine Hydrochloride los ntawm cua sov thiab reacting . Lub mechanism ntawm qhov tshuaj tiv thaiv yog raws li nram no:
C6H5NH2+ CH2=C(C6H5) N(CH3)2→ HC(C6H5)2CH2NWS (CH3)2
HC (C6H5)2CH2NWS (CH3)2+ HCl → C17H21NO · HCl
Hauv cov ntsiab lus, Diphenhydramine Hydrochloride muaj ntau txoj hauv kev sib xyaw ua ke, ntawm cov benzoyl peroxide-sodium nitrite method, aniline-phenylacetonitrile method thiab methylene blue-aniline method yog feem ntau siv. Nyob rau hauv cov txheej txheem kev npaj, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo saib xyuas cov kev tswj hwm ntawm cov xwm txheej xws li cov tshuaj tiv thaiv kab mob thiab cov catalysts kom ntseeg tau tias kev ua haujlwm zoo ntawm cov tshuaj tiv thaiv thiab tau txais kev ua haujlwm siab - zooDiphenhydramine Hydrochloride hmoovcov khoom.
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Tshuaj Formula |
C15H10O5 |
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Exact Mass |
270 |
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Molecular Luj |
270 |
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m/z |
270 (100.0%), 271 (16.2%), 272 (1.2%), 272 (1.0%) |
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Elemental Analysis |
C, 66.67; H, 3.73; O, 29.60 |
Cov txheej txheem tsom xam:
Kev ua haujlwm siab ua kua chromatography:
High -kev ua tau zoo kua chromatography (HPLC) yog ib qho kev tswj xyuas zoo, uas muaj qhov zoo ntawm kev ua haujlwm siab, kev daws teeb meem zoo, thiab kev ua haujlwm yooj yim. Feem ntau, C18 thim rov qab- theem chromatographic kem yog siv, nrog methanol- dej-ferric chloride (30:70:1) raws li theem ntawm lub xov tooj ntawm tes, thiab qhov ntsuas wavelength yog 254 nm.
Electrochemical txoj kev:
Electrochemical txoj kev yog ib txoj kev tshawb xyuas tshuaj sai thiab rhiab heev, uas muaj qhov zoo hauv kev tshawb pom sai. Cov kev siv hluav taws xob feem ntau muaj xws li cyclic voltammetry, square yoj voltammetry, cov txheej txheem cov kauj ruam tas li, thiab lwm yam. Siv cov square yoj voltammetry ua piv txwv, txoj kev no tuaj yeem ntsuas qhov concentration ntau ntawm Diphenhydramine Hydrochloride thiab qhia txog kev sib raug zoo linear.
Infrared spectroscopy:
Infrared spectroscopy yog ib txoj kev tshawb xyuas lub cev thiab tshuaj lom neeg nrog lub hauv paus ntsiab lus yooj yim thiab ua haujlwm yooj yim. Cov qauv raug nias rau hauv ib daim ntawv nyias uas siv KBr pellet, thiab cov infrared absorption spectrum raug kuaj xyuas kom pom cov yam ntxwv ncov txoj hauj lwm thiab spectral duab ntawm Diphenhydramine Hydrochloride.
Atomic absorption spectrometry:
Atomic absorption spectrometry yog ib txoj hauv kev los ntsuas cov hlau, zinc thiab lwm yam kab hauv Diphenhydramine Hydrochloride. Ua ntej, HNO3 yog siv los yaj cov qauv tshuaj, thiab hloov nws mus rau hauv lub xeev ionic, ua spectral ntsuas nyob rau hauv lub atomic absorption ntsuas, thiab txiav txim siab cov ntsiab lus ntawm kab nyob rau hauv tus qauv los ntawm kev sib piv qhov txawv ntawm cov qauv spectrum thiab tus qauv spectrum.
Capillary gas chromatography:
Capillary gas chromatography yog ib txoj hauv kev ntawm kev tshuaj xyuas tshuaj nrog kev nkag siab zoo thiab kev sib cais zoo. Diphenhydramine Hydrochloride feem ntau yog sib cais thiab kuaj pom siv Capillary GC kem nrog N2 raws li cov cab kuj roj ntawm qhov sib cais kub ntawm 10℃txog 300 degree.
stability:
Lub stability ntawmDiphenhydramine Hydrochloride hmoovyog cuam tshuam los ntawm ib puag ncig yam, xws li kub, av noo, lub teeb, thiab lwm yam. Diphenhydramine Hydrochloride crystals yog ruaj khov nyob rau hauv chav tsev kub, tab sis muaj kev cuam tshuam rau noo noo nqus thiab yuav tsum tau muab cia rau hauv qhov chaw qhuav. Tsis txhob kub siab, ncaj qha tshav ntuj thiab lwm yam teeb pom kev zoo, Diphenhydramine Hydrochloride yooj yim rau decompose thiab ua tsis tau. Thaum lub sij hawm tsim, cia thiab siv cov kev npaj, yuav tsum tau them nyiaj mloog mus rau lub stability ntawm Diphenhydramine Hydrochloride los xyuas kom meej qhov zoo thiab zoo ntawm cov tshuaj.
Diphenhydramine Hydrochloride muaj qee yam toxicity, kev siv ntau dhau los yog siv tsis raug yuav ua rau muaj kev cuam tshuam tsis zoo thiab muaj tshuaj lom.
Cov hauv qab no yuav qhia los ntawm ob yam ntawm kev mob lom lom thiab mob ntev.
Mob lom lom:
Qhov mob hnyav ntawm Diphenhydramine Hydrochloride feem ntau tshwm sim raws li lub paj hlwb thiab cov tsos mob ntawm lub plawv. Cov tsos mob ntawm lub paj hlwb muaj xws li qaug zog, kiv taub hau, tsis meej pem, convulsions, thiab lwm yam.; Cov tsos mob ntawm cov hlab plawv muaj xws li bradycardia, hypotension, arrhythmia, thiab lwm yam, thiab tej zaum yuav nrog cov tsos mob xws li dyspnea, qhov ncauj qhuav, thiab insomnia. Thaum cov koob tshuaj ntau dhau lawm, cov neeg mob yuav ntsib cov tsos mob hnyav xws li coma, convulsions, apnea, thiab txawm lub neej - hem.
Mob lom lom:
Kev siv sijhawm ntev -Diphenhydramine Hydrochloride kuj tseem tuaj yeem ua rau muaj kab mob lom. Cov tsos mob ntawm tus kab mob lom muaj xws li qaug zog, kiv taub hau, cem quav, tsis qab los noj mov, thiab qhov muag tsis pom kev. Tsis tas li ntawd, kev siv ntev ntev yuav ua rau muaj kev vam khom tshuaj thiab tshem tawm cov tsos mob. Thaum cov neeg mob muaj cov tsos mob no, lawv yuav tsum tsis txhob siv cov tshuaj sai li sai tau thiab nrhiav kev qhia thiab kev kho mob ntawm tus kws kho mob.
Diphenhydramine hydrochloride yog ib qho tshuaj tiv thaiv kab mob uas muaj ntau yam tshuaj siv tshuaj, dav siv los kho kev tsis haum tshuaj, kev mob kev nkeeg, thiab lwm yam tsos mob. Cov hauv qab no yog cov lus piav qhia ntxaws txog cov txheej txheem ntawm kev ua ntawm diphenhydramine hydrochloride:
Anticholinergic nyhuv
Diphenhydramine hydrochloride kuj muaj cov nyhuv anticholinergic, uas tuaj yeem cuam tshuam qhov excitation ntawm cholinergic neurons thiab txo qhov tso tawm ntawm cholinergic neurotransmitters. Cov nyhuv no yuav pab txo cov tsos mob xws li xeev siab thiab ntuav, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm cov kab mob. Tsis tas li ntawd, cov nyhuv anticholinergic kuj pab txo qhov xeev siab thiab ntuav los ntawm cov leeg nqaij leeg hauv plab hnyuv.
Sedative hypnotic nyhuv
Diphenhydramine hydrochloride tuaj yeem cuam tshuam lub hauv nruab nrab lub paj hlwb kev ua haujlwm, txo kev ntxhov siab thiab ntxhov siab, thiab yog li tsim cov teebmeem hypnotic. Cov nyhuv no ua rau diphenhydramine muaj qee yam kev siv nyiaj hauv kev kho cov kab mob neurological xws li insomnia thiab ntxhov siab vim. Txawm li cas los xij, nws yuav tsum raug sau tseg tias cov nyhuv sedative no kuj tuaj yeem ua rau muaj kev phiv xws li qaug zog thiab qaug zog, yog li yuav tsum tau ceev faj thaum siv nws.
Anti motion sickness effect
Qhov tshwm sim ntawm kev mob tshwm sim yog cuam tshuam nrog kev ua haujlwm tsis zoo ntawm vestibular system hauv pob ntseg sab hauv. Diphenhydramine hydrochloride tuaj yeem txo cov tsos mob ntawm kev mob nkeeg los ntawm inhibiting cov metabolism ntawm dopamine nyob rau hauv lub hauv nruab nrab lub paj hlwb. Tsis tas li ntawd, nws cov tshuaj tiv thaiv kab mob thiab cov tshuaj anticholinergic kuj pab txo cov tsos mob xws li xeev siab thiab ntuav los ntawm kev mob hnyav. Yog li ntawd, diphenhydramine feem ntau yog siv los tiv thaiv thiab kho cov kab mob ntawm lub cev, thiab nws raug nquahu kom coj nws ua ntej yuav tsheb lossis nkoj los txo cov tsos mob tsis xis nyob.
Cov lus nug nquag
Dab tsi yog diphenhydramine hydrochloride siv rau?
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Diphenhydramine yog sivtxo qhov muag liab, khaus, khaus, dej dej; txham; thiab los ntswg, thiab hnoos los ntawm kev ua xua lossis mob khaub thuas. Diphenhydramine kuj tseem siv los kho insomnia (yooj yim pw tsaug zog lossis pw tsaug zog) hauv cov laus, tab sis yuav tsum tsis txhob siv los ua kom tus menyuam tsaug zog.
Puas yog diphenhydramine hydrochloride tib yam li Benadryl?
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Cov khoom xyaw nquag hauv BENADRYL®yog ib qho tshuaj antihistamine hu ua diphenhydramine hydrochloride los yog diphenhydramine HCl. Antihistamines yog siv los kho cov tsos mob ntsig txog hay fever, ua xua ua pa sab saud, lossis cov tsos mob khaub thuas.
Dab tsi yog qhov feem ntau tshwm sim ntawm diphenhydramine?
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Cov kev phiv tshwm sim ntawm diphenhydramine
Xav pw tsaug zog los yog tsaug zog thaum nruab hnub. Kev qaug zog feem ntau tshwm sim nyob ib ncig ntawm 8 teev tom qab noj tshuaj . ...
Qhov ncauj qhuav . ...
Xav tias kiv taub hau lossis tsis khov ntawm koj ob txhais taw, lossis muaj kev nyuaj siab . ...
Cov tawv nqaij rhiab heev rau hnub ci. ...
Eczema los yog daim tawv nqaij ua pob khaus.
Diphenhydramine cuam tshuam rau lub cev li cas?
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Diphenhydramine tau dhau los ua ntej- dhau cov metabolism, uas yog 50-60% ntawm cov tshuaj noj yog metabolized los ntawmlub siabua ntej mus txog qhov systemic ncig. Yuav luag tag nrho cov tshuaj muaj nyob rau hauv daim siab metabolized hauv 24-48 teev, yog li ua rau muaj kev pheej hmoo rau daim siab raug mob.
Cim npe nrov: Diphenhydramine Hydrochloride hmoov CAS 147-24-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom