Arecoline hydobromideZoo li cov hmoov dawb huv, thiab cov xim dawb paug ua rau nws yooj yim los txheeb xyuas hauv teb thiab chaw muag tshuaj. Cov hmoov no tsis muaj ntxhiab nyob rau hauv ib txwm muaj, tab sis muaj qhov iab iab thiab qee yam toxicity. Nws deteriorates thaum raug teeb pom kev. Melting point 170-171℃C. muaj solubility zoo tshaj plaws hauv dej thiab ethanol. Qhov kev ua tau zoo no tso cai rau kev sib xyaw yooj yim nrog cov kuab tshuaj thaum npaj tshuaj thiab ua tau cov tshuaj chemical, uas tau txais txiaj ntsig rau nws cov xwm txheej. Anti cov tshuaj muaj hnyuv tau feem ntau siv rau kev kho tsiaj. Nws muaj cov txiaj ntsig tuag tes tuag taw rau cov leeg ntawm cov leeg ntawm cov kab mob thiab tuaj yeem txhim kho tus tswv lub plab hnyuv, yog li ua cov nyhuv nthuav tawm ntawm cov kab. Mas siv los kho cov khaub ncaws sib kis ib txwm muaj kab mob hauv cov dev thiab nqaij qaib.
Peb Cov Khoom
Arecoline hydobromide COA
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Tshuaj Cov Qauv |
C813No2 |
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Muaj pes tsawg leej |
155 |
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Molecular hnyav |
155 |
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m/z |
155 (100.0%), 156 (8.7%) |
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Kev Ntsuam Xyuas |
C, 61.91; H, 8.44; N, 9.03; O, 20.62 |
Arecolin hydobromide yog ib qho alkaloid hydrobromide extracted los ntawm betel cov txiv ntoo noob lossis tau los ntawm cov tshuaj lom neeg. Nws cov mis molecular yog c 8h1brno2, thiab nws zoo li hmoov dawb crystalline uas yog yooj yim soluble hauv dej thiab ethanol. Raws li kev txhim kho tsim qauv ntawm cov tshuaj txau tso quav, nws daws cov teeb meem tsawg ntawm cov qauv tshuaj lom neeg thiab yooj yim ua rau muaj cov txiaj ntsig zoo hauv thaj chaw kws kho tsiaj.
Cov Ntawv Thov Siv thiab Kho Mob
Antiparasitic Kev Kho Mob: Qhov kev noj tshuaj uas nyiam rau canine thiab feline tapeworm
Nws muaj cov txiaj ntsig tuag tes tuag taw rau cov leeg ntawm cov leeg ntawm cov kev sib tsoo, ua rau muaj kev txhawb nqa acetylaccholine, ua rau muaj kev txhawb nqa spasms, ua rau muaj kev txhawb nqa spasms thiab kev tu cev. Nws cov qauv kev sib txawv suav nrog cov nyhuv me me:
Kev tua ncaj qha: paralyzes txhua feem ntawm cov tapworm (suav nrog cov nqaij npuas npuav), tshwj xeeb rau cov nqaij npua), tshwj xeeb rau cov nqaij npua tsuas yog nkag siab rau ntu ntawm lub taub hau thiab ntu ntu.
Kev sib koom tes tua kab: txhim kho cov neeg ua kom lub plab hnyuv peristalis thiab txhawb nqa cov parasite tshem tawm. Cov ntaub ntawv kuaj mob qhia tau tias tom qab kev tswj hwm ntawm 1.5-2mg / kg hauv cov dev, tus lej nyob hauv 248% uas tuaj yeem ua ke nrog cov tshuaj ua ke ntawm cov pakates.
Cov Ntaub Ntawv Raug: Thaum kho tus 3kg tus kab mob kis nrog Taenia Solium, ob 5mg ntsiav tshuaj (muaj 2.5mg / ntsiav tshuaj ntawmArecoline hydobromide) tau muab tshuaj rau ib qho chaw nyob hauv ib koob tshuaj, ua ke nrog 20mL ntawm 10% kev daws teeb meem magnesium. Tus cab no tau raug tshem tawm tag nrho nyob rau hauv 48 teev tsis muaj ntaub ntawv rov muaj dua.
Cov leeg qev modle modulators: kho cov khoom siv digestive hauv cov tsiaj
Raws li cov coj muscarinic receptor (m ₂ / m α) agonist, nws tuaj yeem sim ua kev ua haujlwm ntawm cov leeg plab zom mov, thiab haum rau cov xwm txheej hauv qab no:
Postoperative plab hnyuv tuag taw kev tuag tes tuag taw: ncua rov qab los ntawm cov hnyuv peristalis hauv dev tom qab kev phais kom tsis muaj menyuam. Subcutaneous txhaj tshuaj ntawm 0.1mg / kg koob tshuaj tshwm sim nyob rau hauv pebfold nce hauv plab hnyuv zaus tsis pub dhau 30 feeb.
Kev quavntsej tawv ncauj: Hauv kev kho mob Hirschsprung tus kab mob hauv cov menyuam yaus laus, ntawm kev sib tw ntawm 0.5mg / kg ua ke nrog lactulose tau txo tus deculose lub sijhawm los ntawm 72 teev mus rau 12 teev.
Tab tuaj yeem: Nees muaj kev nkag siab zoo rau cov tshuaj no, thiab cov miv yuav tsum tswj hwm cov tshuaj (tsawg dua lossis sib npaug nrog 0.3mg / kg) thaum siv nws. Kev siv ntau dhau yuav ua rau lub plab torsionion.
Kev Tshawb Fawb Txog Kev Tshaj Tawm Kev Tshaj Tawm Tsis Muaj Teeb Meem: Sim Ua Tsiaj Qauv Khoom Siv Tshuaj
Hauv kev tshawb fawb ntawm kev tshawb fawb, arecoline hydobromid tau siv dav ua ib tug m receptor agonist rau:
Kev tshawb fawb txog Kev Kho Mob Mechanm: los ntawm kev ua kom lub ntsej muag txha caj qaum dorsal horn m ₁ receptors, ib tus qauv ntawm cov cua sov ntawm cov tshuaj ntsuas cov tshuaj tsis zoo.
Kev ntsuas kev txawj ntse: Tom qab tsim intraperitoneal txhaj tshuaj ntawm 0.3mg / kg koob tshuaj nyob rau hauv nas kev sim nce los ntawm 25%, uas yog siv rau Alzheimer txoj kev txhim kho kab mob.
Kev Ntsuas Cov Qauv: Laurical cov khoom lag luam muaj ntau dua lossis sib npaug nrog 99% (muab kev pabcuam hplc los ntawm milligrams los ntawm milligrams mus rau kilegrams.
Mechanism ntawm Kev Ua thiab Pharmacological Cov Khoom Siv
Ntau hom phiaj kev ua
Chocleergic system ua kom:
Binds ncaj qha rau m receptors, txhawb nqa cov qaub ncaug thiab hws ua pa tawm, thiab ua kom muaj zog lub zog hluav taws xob (2.3 npaug ntawm kev sib tw).
Ionic Channel kev cai:
Blocks the betient gotassium tam sim no (ito) thiab ncua lub peev xwm ntawm cov neeg muaj peev xwm, thiab siv cov tshuaj tiv thaiv ntawm chav kawm III antiarrhythmic tshuaj.
Cov teebmeem metabolic:
Increases acetylcholine levels in the body, improves cognitive function, but long-term use may lead to desensitization of cholinergic receptors.
Cov yam ntxwv ntawm cov chaw ua ke
Kev nqus tau thiab faib khoom ntawm cov dev tsuas yog 18%, thaum nqus tau hauv daim siab, lub raum, thiab cov plab zom mov, thiab cov plab zom mov, thiab cov plab zom mov, thiab cov plab zom mov, thiab cov plab zom mov.
Cov metabolism thiab ua kom zoo dua: metabolized los ntawm daim siab cy450 enzyme rau demetylated arecoline, nrog ib nrab}} lub neej ntawm nws thawj daim ntawv los ntawm cov zis hauv 72 teev.
Raws li ib qho tshuaj lom neeg ib txwm muaj, muaj ntau txoj hauv kev rau synthesizingArecoline hydobromideCov. Ib zaug ntxiv, Kuv yuav sau peb cov hauv qab no rau kev siv xwb.
Txoj kev 1:
Cov synthesis ntawm cov khoom lag luam feem ntau cuam tshuam cov tshuaj tiv thaiv nruab nrab ntawm arecoline thiab hydobromic acid. Raws li derivative ntawm arecoline, bromoaarecoline muaj bromine atoms hauv nws cov qauv. Hauv kev tshawb xav, Bromoaarecoline tuaj yeem hnov mob nrog sodium hydroxide (naoh) los ua cov ntsev ntsev ntawm cov roj ntsha, uas reacloromic acid (HBR) kom kawg daim ntawv hydobromoaarecoline. Tab sis cov txheej txheem no yuav tsum tau nqa tawm hauv ob kauj ruam, vim tias Bromozolall rov qab los nrog sodium hydroxide thiab tsis ncaj qha tsim kom muaj hydrobromoaarecoline.
Cov me nyuam cov ncauj lus kom ntxaws thiab tshuaj lom neeg sib npaug
Hauv cov kauj ruam no, bromoaarecoline (xav tias muaj cov qauv txheej txheem ntawm C9H10No2br, tab sis rau kev yooj yim, peb tsis zoo nrog sodium hydroxide kom ua rau cov ntsev ntsev thiab dej ntawm arecoline.
Tshuaj Muaj Tshuaj:
C9H10No2br + Naoh → C9H10No2No + H2O + Br ⁻
Hauv cov kauj ruam no, lub bromine atom ntawm bromoaarecline yog hloov los ntawm ib tug hydroxide ion (Oh ion (C9HH10No2na) thiab Bromine ion (br ⁻) ntawm arecoline.
Hauv kauj ruam thib ob, cov ntsev sodium ntawm arecoline reacts nrog hydobromic acid los ua hydrobromic arecoline (C9H13NoT22222 h h h. H h h h h.
Tshuaj Muaj Tshuaj:
C9H10No2NO + HBR → C9HH13NoTHNE HBR + NABR
Hauv cov kauj ruam no, cov ntsev ua si ntsev hauv cov yeeb yam hauv cov acid acid {} Cov tshuaj tiv thaiv nurobromic nrog hydobromic acid, ua thiab sodium bromide (NABR).
Txoj kev 2:
Arecoline yog ib qho alkaloid pom hauv betel txiv ntseej, uas muaj cov nitrogen atom hauv nws cov qauv tshuaj lom neeg thiab tuaj yeem lees txais hydrogen ions (h +), ua kom pom Alkalinity. Hydrobromic acid (HBR) yog cov kua qaub muaj zog uas tuaj yeem tso cov kabmob hydrogen ions. Thaum arecoline ntsib hydrobromic acid, cov nitrogen atid, cov nitrogen atid nyob rau hauv cov hydrobromic acid los ua cov hydobromate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm arecolate ntawm Arecolate ntawm Arecolate ntawm Arecolate ntawm Arecolate ntawm Arecolate ntawm Arecolate ntawm Arecolate ntawm Arecolate ntawm Arecolate, uas yog nws.
Arecoline + HBR → C8H14BRNO2
Cov me nyuam yaus kom kawg
1. Npaj cov khoom siv raw:
Firstly, qee qhov nyiaj ntawm arecoline thiab hydobromic acid yuav tsum tau npaj. Ob qho tib si yeeb yam yuav tsum tau muab sib xyaw rau hauv qee qhov kev faib ua feem los xyuas kom meej.
2. Kev sib xyaw xyaw:
Mix Arecoline thiab hydobromic acid nyob rau hauv ib lub thawv uas tsim nyog. Txhawm rau kom muaj kev sib txawv ntawm cov khoom sib txawv, nplawm lossis tuav lub thawv siv tau.
3. Kev saib xyuas kev txiav txim:
Thaum lub sij hawm sib xyaw ua ke, nws tuaj yeem pom tias arecoline maj mam yaj tau hauv hydrobromic acid, tsim homogeneous cov tshuaj tiv thaiv. Meanwhile, vim muaj cov muaj zog acidity ntawm hydobromic acid, qee qhov nyiaj ntawm cov cua sov tej zaum yuav tsim tawm thaum lub sij hawm cov txheej txheem tiv thaiv.
4. Cais ntawm cov khoom:
Tom qab cov tshuaj tiv thaiv tau ua tiav, cov khoom yuav tsum tau sib cais. Vim nws cov solubility siab hauv dej, nws tuaj yeem sib cais los ntawm cov tshuaj tiv thaiv txheej txheem los ntawm cov hau kev xws li kev lim lossis evaporative crystallization.
5. Lim kom huv:
Qhov sib cais nws yuav muaj qee qhov impurities, xws li tsis paub txog arecoline, hydobromic acid, thiab lwm yam kom tau txais cov txheej txheem siab, cov hau kev purification xws li recrystallization thiab kev ntxuav yuav siv tau.
Qauv 3:
Cov tshuaj tiv thaiv ntawm arecoline thiab phosphorus tribromide kom tsim kom muaj cov qauv hluav taws xob tsis yog qhov ncaj qha lossis cov kev sib haum xeeb. Feem ntau,Arecoline hydobromideyog tau los ntawm ncaj qha reacting arecoline nrog hydobromic acid. Txawm li cas los xij, yog tias phosphorus Tribromide (PBR3) yog siv los npaj cov khoom, nws yuav suav nrog cov txheej txheem ntawm cov kauj ruam ntawm cov kauj ruam thiab ua rau muaj kev sib tw ua kom muaj sia.
Cov me nyuam cov ncauj lus kom ntxaws thiab tshuaj lom neeg sib npaug
Cov tshuaj tiv thaiv ntawm arecoline thiab phosphorus Tribromide (Pbr3) tuaj yeem tsim cov chaw sib tua. Kauj ruam no yog ib qho hluav taws xob hloov cov tshuaj tiv thaiv kab mob, qhov twg cov bromine atom hauv phosphorus hloov cov txiv ntoo atom hauv lub betel txiv ntseej alkaloid molecule.
Arecoline + PBR3 → brominated arecoline + ph3
Qhov tshuaj tiv thaiv no yuav tsum tau ua raws li kev mob phem, raws li phosphorus Tribromide kev kub ntxhov nrog dej. Kev tswj hwm ntawm cov tshuaj tiv thaiv kub thiab sijhawm yog qhov tseem ceeb rau kev xaiv thiab tawm los ntawm cov khoom.
Brominated Arecoline Tej zaum yuav dhau mus rau cov kauj ruam hydrolysis, hloov cov pab pawg sib dhos nrog cov pab pawg hydroxyl (Oh)
Brominated Arecoline + H2O → Hydroxylated Arecoline + HBR
Kauj Ruam Nqes Yuav Tsum Tau Rov Ua Ke Hydroxyarecine Nrog hydobromic acid los ua hydrobromic Arecline:
Hydroolated Arecoline + HBR → C8H14BRNO {{} h2o
Ob kauj ruam no yuav tsum tau nqa tawm raws li cov tshuaj tiv thaiv txawv, piv txwv li, thaum lub sijhawm ua kom muaj zog yuav tsum tau nqa tawm hauv ib puag ncig acidic.
Hauv cov ntsiab lus, txawm hais tias txoj hauv kev npaj hydrobromic acid arechromine los ntawm kev ua haujlwm phosphorus nrog kev ua haujlwm phosphorus nrog kev ua haujlwm kom muaj kev nyab xeeb thiab khoom lag luam. Ib qho ntxiv, hom no tsis yog ib txoj kev ua kom npaj rau kev npaj khoom, yog li nws tsis pom zoo kom siv nws hauv chav kuaj lossis kev tsim kev lag luam yam tsis muaj kev sim pov thawj.
NtawmArecoline hydobromide:
1. Lub teb chaws biological siv rau cov neeg reagents biologity, lossis tus qauv antiserum lossis tus kheej tsim qauv lossis tus kab mob raug mob (lossis lawv cov khoom); Lossis hais txog cov khoom siv siv rau kev kuaj kom muaj txiaj ntsig ntawm cov tshuaj tiv thaiv mobile lossis lom zem hauv cov chav ua haujlwm tshwj xeeb thiab tsis nyob hauv (iu).
2. Lub teb chaws biological xa mus rau cov qauv tshuaj pibrated nrog cov qauv kev tsim kho thoob ntiaj teb) rau kev txiav txim siab ntawm kev txiav txim siab ntawm lub potency lossis lom ntawm cov khoom. Lawv cov kev ua haujlwm yog qhia tawm hauv cov koog thoob ntiaj teb (IU) lossis chav nyob (U).
Cim npe nrov: Arecoline Hydobromide Cas 300-08-3, cov neeg tsim khoom, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, rau muag