Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam thiab cov khoom lag luam ntawm ibuprofen hmoov phua 15687-27-1 hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo ib yam 1uprofen hmoov phone 15687-27-1 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Ibuprofen Hmoov, tseem hu ua isobutylbzene profionic acid, cas 15687 {3 {}}}}}}}}}}}} Crystalline hmoov, tsw ntxhiab tsw thiab tsis muaj qab. Insoluble hauv dej, yooj yim soluble hauv cawv thiab ntau lwm cov kuab tshuaj organic, ruaj khov nyob rau hauv chav tsev kub thiab siab. Nws yog ib qho tshuaj antipyretic, analgesic, nosteroidal anti {{}}} mob tshuaj. Cov khoom no tuaj yeem tiv thaiv cyclooxygenase, txo cov synthesis ntawm prostaglandin, thiab tsim analgesic thiab anti- inflammatory cuam tshuam; Nws ua lub luag haujlwm antipyretic lub luag haujlwm los ntawm kev kho mob throffergulation chaw. Nws yog cov lus tsis txaus ntseeg {{14- kub o; kev kub ntxhov thiab mob. Ibuprofen, zoo li lwm tus 2-arylpropionate derivatives (xws li ketoprofen, yog li ntawd, naproxen, napbreak, uas yuav muaj cov teebmeem sib txawv, uas yuav muaj cov teebmeem sib txawv ntawm cov physiology thiab metabolism. Qhov tseeb, (s) - (+) - isobutylbzene propionic acid (piv txwv li dextral ibuprofen) muaj qhov pom tseeb hauv kev sim thiab kev sim tshuaj xyuas. Nyob rau tam sim no, isobutylbenzene propionic acid on kev ua lag luam sib xyaw, uas yog, ib nrab ntawm cov khoom xyaw tsis yog qhov ua tau.
Cov khoom lag luam hauv cov duab daj hauv qab no yog los ntawm cov khoom lag luam no, thiab peb chav kuaj xyuas tuaj yeem muab cov khoom tiav lossis cov cuab yeej siv thev naus laus zis. Thov email rau peb koj cov kev xav tau.
|
Tshuaj Cov Qauv |
C13H18O2 |
|
Muaj pes tsawg leej |
206 |
|
Molecular hnyav |
206 |
|
m/z |
206 (100.0%), 207 (14.1%) |
|
Kev Ntsuam Xyuas |
C, 75.69; H, 8.80; O, 15.51 |
|
|
|
Ibuprofen, raws li tsis muaj steroformal anti {{0} {{
1. Kev tswj hwm mob
Me me rau kev mob mob hnyav: nws yog ib qho kev siv tshuaj tiv thaiv kab mob mob taub hau, mob plab, tus mob dysmenorrhea tuaj yeem ua tiav tus nqi ua mob ntawm 70% -80% tom qab noj ibuprofen ntawm siab. Nws cov kev ua tshuab ntawm kev nqis tes yog ua inibit prostaglandin synthesis thiab txo cov kev sib txuam ntawm cov leeg nqaij du.
Kev mob postperative: Tom qab phais me me, nws tuaj yeem txo cov qhov mob me me thiab txhawb tus neeg mob rov qab los. Nws cov nyhuv analgesic yog qhov sib piv rau cov tshuaj opioid, tab sis nws muaj kev quav me thiab tsawg dua.
Mob mob ntev ntev
2. Kev kho mob ntawm cov kab mob mob
Rheumatoid mob caj dab (RA) thiab osteoarthritis (OA): los ntawm inhibites offness Kev siv ntev ntev tuaj yeem ncua cov qauv sib koom ua ke, tab sis saib xyuas yuav tsum tau them rau kev tiv thaiv txoj hnyuv.
Mos nqaij nqaij, xws li cov leeg nqaij nqaij thiab bursitis thiab bursitis, tuaj yeem ua kom pom kev mob hauv cheeb tsam thiab o, ntxiv rau kev daws teeb meem.
Ankylosing spondylitis (li): los ntawm inhibiting cov txha nqaj qaum thiab txhav qis dua, thiab kho tus mob nraub qaum.
3. Kev tswj cua kub
Ua npaws:Ibuprofen HmoovKev ua ntawm hypothalamic kev tswj kub txwv chaw los txo cov rhiab ntawm cov kev tswj kub. Nws yog haum rau kub cev tshwm sim los ntawm ib txwm khaub thuas, mob khaub thuas lossis lwm yam kev kis mob. Nws cov nyhuv antipyretic tau sib piv rau acetaminophen, tab sis lub sijhawm ntev dua (li 6-8 teev).
Fever tom qab txhaj tshuaj tiv thaiv: Raws li cov tshuaj tiv thaiv, nws tuaj yeem txo cov kev kub ntxhov feverase tom qab txhaj tshuaj.
Mechanism ntawm Kev Ua: Ntau lub hom phiaj Inhibition ntawm kev ua pa thiab mob
1. Inhibition ntawm Prostaglandin synthesis
Los ntawm cov tsis xaiv kev txwv ntawm Cox-1 thiab Cox-2, kev tsim cov khoom sib tham nrog cov prostaglandin E2 (PGE2) thiab thromboxane A2 (TXA2) yog txo. Prostaglandins yog tus yuam sij ntawm kev mob thiab o, thiab lawv cov kev txiav txim siab txo qis, thiab mob cua daj cua dub los ntawm vasodilation thiab exudation.
2. Thaiv cov kev tso tawm ntawm cov mob kho mob
Nws tseem tuaj yeem tiv thaiv aracidonic acid metabolism, txo cov leukocyte chemokines (xws li inhibiting leukocyte infiltration thiab ua kom ua kom tau qhov chaw puas tsuaj, thiab ua kom muaj kev puas tsuaj rau cov nqaij mos.
3. Kev cuam tshuam ntawm Chaw Tswj Kub Kub
Ua yeeb yam ntawm hypothalamic thermoragulatory Center, xws li vasodation kev tswj hwm, tab sis nrhiav kev kho mob kub siab tshaj 39℃ntau dua 39℃lossis yog tus kub taub hau.
Raws li ib qho tshuaj lom neeg ib txwm muaj,Ibuprofen Hmoovmuaj ntau yam kev siv thiab ntau cov qauv ntse. Cov qauv tshuaj synthesis ib txwm muaj nyob hauv qab no:
1. Cov dej cawv cov txheej txheem
Cawv cov qauv roj carbonity, namely bhc txujci, siv isobutylbzene ua cov roj ua kua, los ntawm Friedel craftide txo thiab
Ibuprofen tau synthesized los ntawm catalytic carbonization nyob rau hauv peb kauj ruam.
Cov txheej txheem ntawm ibuprofen los ntawm BHC txoj kev (ethanol carbonylation txoj kev) yog cov txheej txheem zoo thiab ib puag ncig ua phooj ywg kev sib tw. Cov qauv no siv Isobutyl Benzene raws li lub ntsiab pib cov khoom siv carbonyhlation cov tshuaj tiv thaiv los tsim cov molecular cov tshuaj molecular los tsim lub cev molecular los tsim cov molecular tus pob txha pob zeb ntawm ibuprofen. Nyob rau hauv qhov kev txiav txim ntawm catalyst, isobutyl benzene undergoes carbonylings, uas yog ces hloov mus rau hauv ibuprofen los ntawm ib qho ntawm cov kev tawm tsam tom ntej.
Cov kauj ruam tseem ceeb
1. Ethanol carbonylation |
Nyob rau hauv qee lub siab thiab qhov kub thiab txias, isobutyl benzene undergoes carbonytstions xws li kev tsim cov catalysts, ua rau kev tsim cov para iSobutyl acetophenone. Kauj ruam no yog cov kev coj ua tseem ceeb ntawm BHC cov qauv, thiab nws txoj kev ua tau zoo thiab xaiv tau yog qhov tseem ceeb rau kev ua tiav ntawm cov kauj ruam.
2. Cov tshuaj tiv thaiv hws:
Tom ntej no, kev tawm tsam hws tshwm sim tshwm sim ntawm isobutyl acetophenone thiab} c condensing cov neeg sawv cev nyob rau hauv Alkaline tej yam kev mob, ua rau kev tsim ntawm- epoxy esters. Cov kauj ruam no txuas ntxiv ua rau cov qauv molecular thiab lays lub hauv paus rau kev hloov pauv tom qab.
3. Hydrolysis thiab Decarboxylation:
Epoxy esters yog hydrolyzed nyob rau hauv acidic lossis alkaline tej yam kev mob kom tshem tawm cov pab pawg carboxyl thiab tsim kom muaj kev sib txuas ua ke Aldehyde. Cov kauj ruam no yog cov kauj ruam tseem ceeb hauv kev tsim cov pa roj carboxylic acid pawg hauv ibuprofen molecules.
4. Kev kho dua tshiab thiab rov qab ua tiav:
Aldehydes tau hloov pauv mus ua dej cawv los ntawm lawv cov qauv molecular tau hloov kho los ntawm catalytic cov kev tiv thaiv tus kheej tau txais ibuprofen lossis nws cov kev ua ntej. Cov kauj ruam no suav nrog kev xaiv ntau yam tshuaj tiv thaiv ntau yam tshuaj tiv thaiv thiab catalysts, uas muaj qhov cuam tshuam tseem ceeb ntawm cov txiaj ntsig thiab kev coj dawb huv ntawm cov khoom.
5. Purification:
Cov kauj ruam lim dej ua ke xws li distillation thiab crystallization yog siv los tshem cov impurities thiab tau txais siab} {purity ibuprofen khoom. Cov txheej txheem lim dej yog qhov tseem ceeb rau kev ua kom zoo thiab ruaj khov ntawm cov khoom.
2. Olefef catalytic hydrogenation txoj kev
Zeipsen tau npaj los ntawm hydrogenation ntawm 2 {{{{- (6-nenenea metoxy-nenenea metoxy-nenaseces
Lub Synthesis txoj kev ntawm catalrofen los ntawm catalrofen los ntawm edefins yog ib txoj kev npaj ibuprofen los ntawm kev siv cov tshuaj catalyertic hydrogenation ntawm Olfins. Cov txheej txheem no tsuas yog tso siab rau kev ua ntawm catalysts rau hydrogenate thiab txo cov nyiaj txhiv tawm (xws li cov roj txheem hloov dua tshiab cov roj ntsha, thaum kawg ua ibuprofen. Cov hauv qab no yog cov lus qhia ntxaws ntxaws txog cov synthesis txoj kev:
1. Xaiv cov khoom pib thiab catalysts
Pib Khoom:
Nyob rau hauv txoj kev ntawm catalytic hydrogenation ntawm Olfins los ua ibuprofen, tebchaw muaj cov qauv tshwj xeeb olinf me me tau raug xaiv los ua cov khoom pib. Cov kev sib txuas no yuav tsum tau ua tib zoo tsim kom muaj kev tsim kho kom meej ntawm hydrogenation thiab hloov dua siab tshiab.
Kev xaiv catalyst:
Xaiv cov catalyst yog tus yuam sij rau olefin catalytic hydrogenation. Cov Catalysts ib txwm muaj xws li palladium catalysts (xws li palladium catalysts (platinum, thiab lwm yam) thiab tsis muaj npe ntses catalalysts (xws li Nickel, cobalt, thiab lwm yam). Cov catalysts no tuaj yeem txhawb nqa cov tshuaj hydrogenation hydrogenation ntawm Olefins thaum tswj hwm siab xaiv thiab ruaj khov.
Tom qab cov kauj ruam hloov dua siab tshiab
Hloov siab hloov siab:
Tom qab catalytic hydrogenation ntawm edefins, cov khoom lag luam feem ntau yuav tsum tau cov kauj ruam uas hloov dua siab tshiab los ua ibuprofrofen. Cov kauj ruam hloov dua siab tshiab no suav nrog kev cuam tshuam xws li hws, oxidation, kev coj ua ntawm cov ntaub ntawv pib thiab yam xav tau cov qauv molecular ntawm ibuprofen.
Purification thiab sib cais:
Tom qab ua tiav txhua kauj ruam hloov dua siab tshiab, cov khoom yuav tsum tau ua kom huv thiab sib cais kom tshem tawm cov impurities thiab txhim kho lub purity ntawm ibuprofen. Qhov no feem ntau suav nrog cov kauj ruam xws li distillation, crystallization, thiab pom.
Lub Synthesis txoj kev ntawm ibuprofen los ntawm catalystic hydrogenation ntawm Olfins yog qhov nyuaj tab sis muaj txiaj ntsig zoo. Nws tso siab rau kev xaiv ntawm catalysts thiab kev ua haujlwm ntawm cov tshuaj tiv thaiv kom ua tiav hydrogenation thiab txuas ntxiv confefins. Los ntawm hom no, siab {- Kev Purity Ibuprofen cov khoom tuaj yeem npaj tau txais kev lag luam ntawm cov tshuaj lag luam.
melting point 77 - 78 degree, kev sib hloov tshwj xeeb []}}}}}}}}}} Dej, ywj siab soluble hauv acetone, methanol thiab methylene chloride. Nws yaj nyob rau hauv kev daws teeb meem ntawm alkali hydroxides thiab carbonates. , Acidity coefficient (PKA) PKA 4.45 ± 0./200 {} (= 25
chaw muag khoom
Chaw muag khoom
Lub analgesic thiab anti - qhov kev siv tshuab hluav taws xob ntawmIbuprofen HmoovTsis tau ua tiav elucidated, thiab nws yuav ua hauv zos ntawm cov ntaub so ntswg los ntawm kev ua haujlwm ntawm prostaglandins lossis lwm tus neurotransmitters. Vim tias qhov kev txwv tsis pub ua haujlwm thiab Lysosomal enzyme tso tawm, qhov kev mob impulses nyob rau hauv daim ntaub so ntswg yog txo, thiab rhiab ntawm kev mob cov tshuaj mob yog qis. Kev kho mob ntawm gout muaj kev tiv thaiv - mob thiab ntsuas kev ntsuas, tab sis tsis tuaj yeem kho cov hyperuricemia. Lub tshuab kho mob dysmenorrhea yuav yog qhov cuam tshuam ntawm prostaglandin synthesis, uas ua rau txo qis hauv cov kev txo mob hauv cov kev sib txuas lus.
2 Pharmeroninetics
Pharmaconinetics
2.1 Kev tswjfwm ntawm qhov yooj yim los nqus, thiab nqus qeeb thaum noj nrog zaub mov, tab sis tus nqi nqus tsis txo qis. Noj antacids muaj aluminium thiab magnesium tsis cuam tshuam kev nqus. Lub Plasma Protein khi tus nqi yog 99%. Tom qab noj cov tshuaj, cov tshuaj hauv cov tshuaj muaj kev xav txog nws lub ncov hauv 1.2 - 2.1 teev. Qhov ntau npaum li cas yog 200mg, thiab cov tshuaj hauv cov tshuaj muaj 22-27 μ μ G / ML. Thaum cov tshuaj yog 400mg, nws yog 23-45 μ g / mL, thiab thaum twg tshuaj, thiab thaum twg yog 600mg, nws yog 43-57 μ g / ml. Ib nrab-lub neej tom qab ib pawg tswj hwm feem ntau yog 1.8 txog 2 teev. Cov khoom no yog metabolized nyob rau hauv daim siab, nrog 60-90% tawm los ntawm lub raum nyob rau hauv 24% yog ib feem ntawm daim foos thiab ib feem yog ua yeeb yam.
Cim npe nrov: Ibuprofen Hmoov Cas 15687-27-1, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas, Lag Luam Wholesale, Yuav, Rau, Rau Cov Muag Khoom