Hydroxyzine dihydrochloride, tseem hu ua Antale, muaj cov tshuaj formula C21H29Cl3N2O2, CAS 2192-20-3, Lub npe tshuaj yog 2- [2- [4- (4-}chlorophenyl) phenylmethyl{ {10}}piperazinyl] ethoxy] - ethanol dihydrochloride, uas yog cov organic compound nrog ntau yam kev siv kho mob. Nws yog cov hmoov dawb crystalline, tsis muaj ntxhiab, iab hauv saj, yooj yim soluble hauv dej thiab ethanol, tab sis insoluble hauv ether. Hydroxyzine hydrochloride exerts nws cov nyhuv sedative los ntawm inhibiting cov kev ua ntawm neurotransmitters xws li dopamine thiab serotonin nyob rau hauv lub hauv paus paj hlwb. Cov tshuaj no tuaj yeem txo qis cortical excitability, alleviate cov tsos mob ntawm kev xav excitement thiab hyperactivity, xws li chim siab thiab nyob tsis tswm, thiab thaiv histamine receptors los tiv thaiv kev tsis haum tshuaj los ntawm histamine. Nws muaj cov txiaj ntsig zoo rau ntawm daim tawv nqaij khaus, liab, thiab o cov tsos mob xws li urticaria thiab hu rau dermatitis. Vim nws lub peev xwm los cuam tshuam qhov sib npaug ntawm cov neurotransmitters hauv lub hlwb thiab ua rau muaj kev ua haujlwm ntawm gamma aminobutyric acid type A receptors, hydroxyzine hydrochloride tuaj yeem txhawb kev pw tsaug zog. Cov tshuaj no yog cov khoom siv kuaj thiab raug txwv tsis pub siv rau lwm lub hom phiaj.
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Tshuaj Formula |
C21H27ClN2O2 |
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Exact Mass |
374.18 |
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Molecular Luj |
374.91 |
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m/z |
374.18 (100.0%), 376.17 (32.0%), 375.18 (22.7%), 377.18 (7.3%), 376.18 (2.5%) |
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Elemental Analysis |
C, 67,28; H, 7,26; 9,46 ;ua. N, 7,47; 8,53 ua |
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Hydroxyzine dihydrochloride, tseem hu ua Antale lossis Hydroxyzine, yog cov tshuaj uas tsis yog benzodiazepine los tiv thaiv kev ntxhov siab nrog ntau yam kev siv kho mob.
Nws yog ib qho tshuaj tiv thaiv kev ntxhov siab zoo uas tuaj yeem siv los kho cov tsos mob xws li kev ntxhov siab, ntxhov siab, thiab ntxhov siab hauv neurosis, nrog rau kev ntxhov siab thiab ntxhov siab hauv cov kab mob hauv lub cev. Nws tsim cov nyhuv sedative los ntawm inhibiting central paj hlwb excitability, txo cov paj hlwb overactive. Cov tshuaj no tuaj yeem tswj hwm qhov sib npaug ntawm cov neurotransmitters serotonin thiab norepinephrine hauv lub hlwb, txo kev ntxhov siab los ntawm qhov txawv txav ntawm cov neurotransmitters no. Rau cov neeg mob uas muaj kev ntxhov siab me ntsis, nws tuaj yeem txhim kho lawv cov tsos mob ntxhov siab thiab txhim kho lawv lub neej zoo.
Hauv kev kho kev ntxhov siab, qhov ntau npaum li cas yog hloov kho raws li qhov xwm txheej tshwj xeeb ntawm tus neeg mob. Nws yog feem ntau pom zoo kom pib nrog qhov tsawg npaum li cas thiab maj mam nce nws raws li kev ua tau zoo thiab kam rau ua. Thaum siv, nws yuav tsum tau ua tib zoo saib xyuas tus neeg mob qhov kev hloov pauv thiab muaj kev phiv tshwm sim xws li qaug zog, qaug zog, mob taub hau, thiab lwm yam. Yog tias cov tsos mob tshwm sim los yog hnyav dua, nws yuav tsum tau sab laj nrog kws kho mob raws sij hawm thiab kho cov phiaj xwm kho mob. .
Nws kuj muaj cov teebmeem antihistamine, uas tuaj yeem thaiv cov receptors histamine thiab txo cov stimulation histamine ntawm cov hlwb mast thiab cov leeg nqaij, yog li tiv thaiv kev tsis haum tshuaj. Cov yam ntxwv no ua rau nws siv dav hauv kev kho cov kab mob ua xua, xws li urticaria, hu rau dermatitis thiab lwm yam tawv nqaij khaus, liab thiab o.
Thaum kho cov kab mob ua xua, feem ntau yog siv ua ke nrog lwm cov tshuaj tiv thaiv kev ua xua los txhim kho kev ua tau zoo. Nyob rau tib lub sijhawm, kev saib xyuas yuav tsum tau them rau tus neeg mob qhov kev tsis haum tshuaj keeb kwm thiab kev ua xua kom tsis txhob kis tus kab mob ntxiv uas yuav ua rau cov tsos mob hnyav dua. Thaum siv, nws yuav tsum tau soj ntsuam cov kev hloov pauv ntawm tus neeg mob tus mob thiab seb puas muaj kev tsis haum tshuaj lossis lwm yam kev phiv tshwm sim.
3. Cov nyhuv sedative
Nws muaj cov nyhuv sedative hauv nruab nrab, uas tuaj yeem txo qhov excitability ntawm cerebral cortex, alleviate cov tsos mob ntawm kev xav excitement thiab hyperactivity, xws li chim siab thiab nyob tsis tswm. Cov yam ntxwv no ua rau nws muaj txiaj ntsig zoo hauv kev kho mob pw tsaug zog xws li insomnia thiab neurasthenia.
Thaum kho insomnia, nws tuaj yeem txo lub sijhawm pw tsaug zog, ua kom tag nrho lub sijhawm pw tsaug zog, thiab txhim kho kev pw tsaug zog zoo. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias kev siv mus ntev yuav ua rau muaj tshuaj tiv thaiv thiab kev vam khom, yog li nws yuav tsum siv kom tsim nyog raws li kev qhia ntawm tus kws kho mob kom tsis txhob muaj kev tsim txom thiab siv tsis raug.
Nws kuj muaj cov nyhuv hypnotic, uas tuaj yeem ua rau muaj qhov ntau ntawm cov tshuaj chloride ion channel qhib kev sib kho los ntawm gamma aminobutyric acid hom A receptors, ua rau postsynaptic membrane hyperpolarization, yog li txo cov kev ua haujlwm neuronal thiab inducing pw tsaug zog. Cov yam ntxwv no ua rau nws muaj txiaj ntsig zoo hauv kev kho mob pw tsaug zog xws li insomnia thiab kev ntxhov siab.
Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias nws cov nyhuv hypnotic tuaj yeem nrog qee qhov kev mob tshwm sim, xws li qaug zog, kiv taub hau, thiab lwm yam. Yog li ntawd, nws yuav tsum tau saib xyuas tus neeg mob qhov kev hloov pauv thiab seb puas muaj kev phiv tshwm sim thaum siv. Nyob rau tib lub sijhawm, nws yog ib qho tsim nyog yuav tsum tsis txhob siv nws hauv cov xwm txheej uas yuav tsum tau muaj kev mloog zoo, xws li kev tsav tsheb lossis kev ua haujlwm ntawm lub tshuab, txhawm rau tiv thaiv kev sib tsoo.
5. Cov nyhuv so ntawm cov leeg
Nws kuj muaj qee cov leeg nqaij so, uas tuaj yeem txo cov leeg nro thiab mob. Cov yam ntxwv no ua rau nws muaj txiaj ntsig zoo hauv kev kho cov kab mob xws li cov leeg nqaij spasms thiab cov leeg pob txha.
Thaum kho cov leeg nqaij spasms, nws tuaj yeem so cov leeg nqaij, txo qhov mob thiab tsis xis nyob. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias nws cov leeg nqaij so tuaj yeem nrog qee qhov kev mob tshwm sim, xws li qaug zog, kiv taub hau, thiab lwm yam. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau saib xyuas tus neeg mob qhov kev hloov pauv thiab seb puas muaj kev phiv tshwm sim thaum siv. Nyob rau tib lub sijhawm, nws yog ib qho tsim nyog yuav tsum tsis txhob siv lwm cov tshuaj uas muaj cov leeg nqaij so rau tib lub sijhawm, txhawm rau tiv thaiv qhov tshwm sim ntawm kev sib tshooj thiab qhov ua rau muaj kev cuam tshuam tsis zoo.
Kev sib cuam tshuam nrog lwm yam tshuaj
Thaum siv ua ke nrog lwm cov tshuaj, tej zaum yuav muaj kev cuam tshuam uas cuam tshuam rau kev ua tau zoo thiab kev nyab xeeb. Nov yog qee yam tshuaj uas cuam tshuam nrog hydroxyzine hydrochloride:
Barbital: Thaum siv ua ke nrog barbiturates, nws tuaj yeem txhim kho lub hauv paus inhibitory nyhuv ntawm barbiturates, ua rau muaj zog sedative thiab hypnotic teebmeem. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau saib xyuas tus neeg mob qhov kev hloov pauv thiab seb puas muaj kev phiv tshuaj xws li sedation ntau dhau thiab hypnosis thaum siv.
Cov tshuaj Antiepileptic: Thaum siv ua ke nrog cov tshuaj tiv thaiv kab mob, qhov ua tau zoo ntawm cov tshuaj tiv thaiv kab mob yuav raug txo kom tsawg, ua rau muaj qhov ua rau qaug dab peg. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau saib xyuas tus neeg mob qhov kev hloov pauv thiab seb puas muaj qhov ua rau qaug dab peg thaum siv.
Cov tshuaj Anticholinergic: Thaum siv nrog cov tshuaj anticholinergic, lawv tuaj yeem txhim kho cov nyhuv anticholinergic, ua rau muaj kev cuam tshuam tsis zoo xws li qhov ncauj qhuav thiab cem quav. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau saib xyuas tus neeg mob qhov kev hloov pauv thiab seb puas muaj kev cuam tshuam tsis zoo thaum siv.
Cov tshuaj sedative hypnotic: Thaum siv ua ke nrog cov tshuaj sedative hypnotic, nws yuav ua rau kom sedative thiab hypnotic teebmeem, ua rau muaj kev cuam tshuam tsis zoo xws li qaug zog thiab kiv taub hau. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tsis txhob siv lwm cov tshuaj nrog sedative thiab hypnotic teebmeem tib lub sijhawm thaum siv, txhawm rau tiv thaiv qhov tshwm sim ntawm kev sib tshooj thiab qhov ua rau muaj kev cuam tshuam tsis zoo.
Opioids: Thaum siv ua ke nrog cov tshuaj opioid, lawv tuaj yeem txhim kho cov nyhuv analgesic ntawm cov tshuaj opioid, tab sis kuj tuaj yeem ua rau muaj kev tiv thaiv thiab kev vam khom. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum nruj me ntsis tswj cov koob tshuaj thiab kev kho mob thaum siv kom tsis txhob muaj kev tsim txom thiab siv tsis raug.
Hydroxyzine dihydrochlorideyog ib qho tshuaj uas muaj ntau yam kev kho mob, suav nrog kev tiv thaiv kev ntxhov siab, tshuaj tiv thaiv kab mob, tshuaj sedative, hypnotic, thiab cov leeg nqaij so. Txawm li cas los xij, kev saib xyuas yuav tsum tau them rau cov kev mob tshwm sim thiab kev cuam tshuam ntawm cov tshuaj thaum siv, nrog rau cov tshuaj contraindications thiab ceev faj rau cov neeg tshwj xeeb. Thaum siv hydroxyzine hydrochloride, nws yog ib qho tsim nyog yuav tsum ua raws li tus kws kho mob cov lus qhia nruj me ntsis, tswj cov koob tshuaj thiab kev kho mob kom tsim nyog, thiab zam kev tsim txom thiab kev siv tsis raug uas yuav ua rau muaj kev cuam tshuam tsis zoo. Nyob rau tib lub sijhawm, nws yuav tsum tau ua tib zoo saib xyuas cov kev hloov pauv ntawm tus neeg mob thiab seb puas muaj kev cuam tshuam tsis zoo, thiab kho cov phiaj xwm kho raws sijhawm kom ntseeg tau tias muaj txiaj ntsig thiab kev nyab xeeb.
Hydroxyzine hydrochloride, tseem hu ua Antale los yog Hydroxyzine, yog ib qho organic compound nrog ntau yam kev kho mob siv hauv kev kho mob, xws li tshuaj tiv thaiv kev ntxhov siab, tshuaj tua kab mob, sedation, thiab cov leeg nqaij so. Cov hauv qab no yog cov lus piav qhia ntxaws ntxaws ntawm cov tshuaj pharmacological ntawm hydroxyzine hydrochloride:
Hydroxyzine hydrochloride tuaj yeem thaiv histamine receptors, yog li txo cov tsos mob tshwm sim los ntawm kev tsis haum tshuaj. Histone yog ib qho inflammatory mediator hauv lub cev uas ua lub luag haujlwm tseem ceeb hauv kev ua xua. Thaum allergens nkag mus rau hauv lub cev, lawv txhawb mast hlwb tso tawm histamine, ua rau ib tug series ntawm kev tsis haum tshuaj xws li tawv nqaij khaus, liab, txham, los ntswg qhov ntswg, thiab lwm yam. Hydroxyzine hydrochloride inhibits lom cov teebmeem ntawm histamine los ntawm thaiv nws receptors, li no alleviating. Cov tsos mob ua xua.
Hydroxyzine hydrochloride muaj lub hauv paus sedative thiab tiv thaiv kev ntxhov siab, uas tuaj yeem txo qhov excitability ntawm cerebral cortex, txo cov firing zaus ntawm neurons, thiab yog li tsim sedative thiab tiv thaiv kev ntxhov siab vim. Cov txheej txheem ntawm kev ua no yuav cuam tshuam rau nws qhov cuam tshuam rau qhov sib npaug ntawm cov neurotransmitters hauv lub hlwb, xws li serotonin thiab norepinephrine. Los ntawm kev tswj cov qib ntawm cov neurotransmitters, hydroxyzine hydrochloride tuaj yeem txo cov kev xav tsis zoo xws li kev ntxhov siab thiab ntxhov siab, thiab pab txhim kho kev pw tsaug zog zoo.
Hydroxyzine hydrochloride kuj muaj qee cov leeg nqaij so, uas tuaj yeem txo cov leeg nro thiab mob. Cov nyhuv no yuav cuam tshuam rau nws cov kev cuam tshuam rau cov txheej txheem sib kis ntawm cov kab mob neuromuscular hlws ris, los ntawm inhibiting qhov tso tawm ntawm acetylcholine los yog thaiv nws cov receptors, yog li txo cov leeg nqaij thiab nro.
Cov txheej txheem metabolic thiab excretion ntawm hydroxyzine hydrochloride hauv lub cev yog qhov nyuaj. Tom qab kev tswj hwm qhov ncauj lossis intramuscular, cov tshuaj tuaj yeem nqus tau sai thiab nkag mus rau hauv cov hlab ntsha. Nws qhov kev tshem tawm ib nrab ntawm lub neej txawv ntawm cov tib neeg, tab sis feem ntau yog 710 teev hauv cov neeg laus thiab 67 teev hauv cov menyuam yaus, thaum nws yuav ntev dua rau cov neeg laus thiab cov neeg muaj lub raum tsis txaus.
Hydroxyzine hydrochloride feem ntau yog metabolized los ntawm daim siab, thiab qee cov metabolites tseem muaj cov tshuaj pharmacological. Cov metabolites no yuav raug tawm ntawm lub cev los ntawm cov zis los yog quav. Yog li ntawd, thaum siv hydroxyzine hydrochloride, yuav tsum tau them nyiaj mloog mus rau tus neeg mob lub siab thiab lub raum kev ua haujlwm kom tsis txhob muaj cov tshuaj sib xyaw thiab cov tshuaj tsis haum.
Hydroxyzine hydrochloride tuaj yeem cuam tshuam nrog lwm cov tshuaj thaum siv ua ke, cuam tshuam rau kev ua tau zoo thiab kev nyab xeeb. Nov yog qee hom tshuaj uas cuam tshuam nrog hydroxyzine hydrochloride:
(1) Central nervous system depressants:
Thaum siv los ua ke nrog barbiturates, opioids, lossis lwm yam hauv nruab nrab lub paj hlwb kev nyuaj siab, hydroxyzine hydrochloride tuaj yeem txhim kho qhov cuam tshuam hauv nruab nrab ntawm cov tshuaj no, ua rau muaj kev cuam tshuam tsis zoo xws li sedation, hypnosis, thiab ua pa nyuaj siab. Yog li ntawd, yuav tsum tau ceev faj thaum siv cov tshuaj no, thiab cov neeg mob cov kev hloov pauv yuav tsum tau saib xyuas kom zoo.
(2) Anticholinergic tshuaj:
Thaum siv nrog cov tshuaj anticholinergic, hydroxyzine hydrochloride tuaj yeem txhim kho cov nyhuv anticholinergic, ua rau muaj kev cuam tshuam tsis zoo xws li qhov ncauj qhuav, cem quav, thiab qhov muag tsis pom kev. Yog li ntawd, thaum siv cov tshuaj no, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo saib xyuas cov kev hloov pauv ntawm tus neeg mob cov tsos mob thiab kho cov phiaj xwm kho raws sijhawm.
(3) Sedative hypnotic tshuaj:
Thaum siv nrog sedative hypnotic tshuaj, hydroxyzine hydrochloride yuav ua rau kom sedative thiab hypnotic teebmeem, ua rau aggravated phiv xws li qaug zog thiab kiv taub hau. Yog li ntawd, thaum siv cov tshuaj no, nws yog ib qho tsim nyog yuav tsum tsis txhob siv lwm cov tshuaj nrog sedative thiab hypnotic teebmeem tib lub sijhawm, txhawm rau tiv thaiv qhov tshwm sim ntawm kev sib tshooj thiab qhov ua rau muaj kev cuam tshuam tsis zoo.
(4) Antiepileptic tshuaj:
Thaum siv ua ke nrog cov tshuaj tiv thaiv kab mob, hydroxyzine hydrochloride tuaj yeem txo qhov kev ua tau zoo ntawm cov tshuaj tiv thaiv kab mob, ua rau ua rau mob qaug dab peg. Yog li ntawd, yuav tsum tau ua tib zoo saib xyuas tus neeg mob qhov kev hloov pauv thiab kho cov phiaj xwm kho raws li xav tau thaum siv cov tshuaj no.
Hydroxyzine dihydrochloridetej zaum yuav ua rau muaj kev phiv thaum siv, xws li qaug zog, qaug zog, mob taub hau, kiv taub hau, thiab lwm yam. Tsis tas li ntawd, kev siv mus sij hawm ntev kuj yuav ua rau muaj kev vam khom. Yog li ntawd, thaum siv hydroxyzine hydrochloride, nws yog ib qho tsim nyog yuav tsum nruj me ntsis tswj cov koob tshuaj thiab lub sijhawm ntawm kev kho mob kom tsis txhob muaj kev tsim txom thiab kev siv tsis raug uas yuav ua rau muaj kev cuam tshuam tsis zoo.
Nov yog qee qhov contraindications rau kev siv hydroxyzine hydrochloride:
Nws yog contraindicated rau cov neeg mob ua xua rau hydroxyzine hydrochloride los yog lwm yam piperazine derivatives.
Nws yog contraindicated rau cov neeg uas muaj leukopenia, vim hydroxyzine hydrochloride tuaj yeem ua rau cov pob txha pob txha.
Cov neeg mob qaug dab peg yuav tsum tsis txhob siv hydroxyzine hydrochloride vim nws tuaj yeem txo cov tshuaj tiv thaiv kab mob thiab ua rau qaug dab peg.
Cov poj niam cev xeeb tub thiab lactating poj niam yuav tsum tsis txhob siv hydroxyzine hydrochloride vim nws yuav muaj kev cuam tshuam rau tus me nyuam hauv plab los yog me nyuam mos.
Cov neeg uas muaj lub siab thiab lub raum tsis ua haujlwm yuav tsum tau ceev faj vim tias lawv cov metabolism thiab kev tso tawm tsis muaj zog, uas tuaj yeem ua rau cov tshuaj tsub zuj zuj thiab ua rau muaj kev cuam tshuam tsis zoo.
Cim npe nrov: hydroxyzine dihydrochloride cas 2192-20-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom