N-Cbz-Nortropinoneyog ib qho organic compound nrog cov mis molecular C23H21NO3l, CAS 130753-13-8. Nws yog dawb los yog tawm -dawb khoom nyob rau hauv daim ntawv ntawm crystals. Muaj ntau txoj kev crystallization, thiab nws tuaj yeem ua phaj-zoo li, pas nrig-zoo li, koob-zoo li thiab lwm yam muaju. Nyob ruaj khov nyob rau hauv huab cua, tab sis maj mam tig daj nyob rau hauv lub teeb muaj zog. Nws muaj zog niacinamide tsw. Nws tuaj yeem yaj hauv qee cov kuab tshuaj organic, xws li chloroform, methanol, dimethyl sulfoxide, N, N-dimethylformamide, thiab lwm yam, tab sis nws cov solubility hauv dej tsis zoo, thiab nws tsuas yog yaj hauv dej boiled xwb. Nws tsis yog volatile ntawm chav tsev kub. Nws yog ib qho organic compound feem ntau siv hauv kev kho mob. Nws muaj ntau yam kev ua si lom neeg thiab cov tshuaj pharmacological, thiab siv ntau yam kev siv. Nws muaj ntau daim ntawv thov muaj txiaj ntsig thiab yog qhov yooj yim, nyab xeeb thiab yooj yim-rau-tau nruab nrab qhov sib xyaw, thiab tau maj mam dhau los ua kev tshawb fawb hotspot hauv ntau qhov chaw.
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Tshuaj Formula |
C15H17NO3 |
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Exact Mass |
259 |
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Molecular Luj |
259 |
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m/z |
259 (100.0%), 260 (16.2%), 261 (1.2%) |
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Elemental Analysis |
C, 69.48; H, 6.61; N, 5.40; O, 18.51 |
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N-Cbz-Nortropinone, raws li ib tug organic compound nrog ib tug tshwj xeeb tshuaj qauv, tau qhia muaj peev xwm daim ntawv thov nqi nyob rau hauv lub tshav pob ntawm cov ntaub ntawv tshiab, tshwj xeeb tshaj yog nyob rau hauv cov ntaub ntawv sib nqus.
Cov khoom tseem ceeb ntawm N-benzyloxycarbonyl-demethyltropinone
Nws cov mis mos molecular yog C15H17NO3, nrog rau qhov hnyav molecular ntawm 259.30, thiab nws muaj cov qauv tshuaj tshwj xeeb thiab lub cev muaj zog. Nws feem ntau muaj nyob rau hauv daim ntawv ntawm dawb los yog tawm dawb hmoov, nrog rau tej yam thermal thiab tshuaj stability. Nws muaj qhov zoo solubility hauv cov kuab tshuaj organic, ua rau nws yog ib qho tseem ceeb raw cov ntaub ntawv rau synthesizing magnetic cov ntaub ntawv.
Sib nqus mechanism ntawm cov khoom sib nqus
Magnetism feem ntau yog los ntawm cov hlau nplaum hlau ions los yog sib nqus nanoparticles hauv nws cov qauv molecular. Cov hlau nplaum hlau ions los yog nanoparticles yuav magnetize nyob rau hauv qhov kev txiav txim ntawm ib tug magnetic teb, yog li ua magnetism. Lub caij no, kev sib cuam tshuam quab yuam kuj tuaj yeem cuam tshuam cov khoom sib nqus ntawm cov khoom sib nqus. Piv txwv li, kev sib cuam tshuam hauv nruab nrab xws li hydrogen bonds thiab van der Waals rog tuaj yeem cuam tshuam rau cov qauv sib nqus thiab cov txheej txheem sib nqus ntawm cov khoom sib nqus, yog li cuam tshuam rau lawv cov khoom sib nqus.5,
Synthesis ntawm Magnetic Polymer Materials
Cov khoom siv polymer nrog cov khoom sib nqus tuaj yeem tsim los ntawm kev sib txuas nrog cov saw hlau los ntawm cov tshuaj lom neeg tshwj xeeb. Cov khoom siv no sib xyaw ua ke ntawm cov khoom siv polymer nrog kev sib nqus teb ntawm cov khoom sib nqus, thiab muaj cov ntawv thov dav dav hauv cov teb xws li cov ntaub ntawv ntse, sensors, thiab cov ntaub ntawv sib nqus. Piv txwv li, los ntawm kev sib txuas nrog cov khoom siv hluav taws xob xws li polystyrene thiab polyethylene, cov ntaub ntawv sib nqus polymer nrog cov khoom sib nqus zoo tuaj yeem npaj tau.
Kev npaj ntawm magnetic nanoparticles
Los ntawm kev siv cov qauv tshuaj tshwj xeeb, cov hlau nplaum nanoparticles uas muaj qhov loj me thiab cov khoom sib nqus tuaj yeem npaj tau los ntawm cov txheej txheem tshuaj. Cov nanoparticles no muaj ntau yam kev siv hauv biomedical, magnetic kua, sib nqus cov ntaub ntawv, thiab lwm yam. Piv txwv li, los ntawm kev sib txuas nrog cov hlau ions xws li hlau, cobalt, thiab npib tsib xee, sib nqus nanoparticles nrog cov khoom sib nqus zoo heev thiab biocompatibility tuaj yeem npaj tau, uas tuaj yeem siv rau kev sib cais ntawm tes, xa tshuaj, thiab lwm yam kev siv hauv biomedical field.
Daim ntawv thov kev cia siab ntawm cov khoom sib nqus
Biomedical teb
Nws muaj dav thov kev cia siab nyob rau hauv biomedical teb. Piv txwv li, nws tuaj yeem siv rau hauv thaj chaw xws li kev sib cais ntawm tes, xa tshuaj, thiab biomarkers. Los ntawm kev tswj cov particle loj thiab cov khoom nto ntawm cov khoom sib nqus, kev sib cais ntawm tes meej thiab cov tshuaj xa mus tau tiav.
Cov ntaub ntawv khaws cia
Nws kuj tseem muaj peev xwm siv tau tus nqi hauv kev khaws ntaub ntawv. Los ntawm kev ua kom zoo ntawm cov khoom sib nqus thiab kev ruaj ntseg ntawm cov khoom sib nqus, siab -cov ntaub ntawv kaw lus sib nqus tuaj yeem npaj tau los txhim kho lub peev xwm thiab ruaj khov ntawm cov ntaub ntawv khaws cia.
Kev tiv thaiv ib puag ncig
Nws kuj tseem siv tau rau hauv kev tiv thaiv ib puag ncig. Piv txwv li, nws tuaj yeem siv los kho cov khoom tsis zoo xws li cov hlau hnyav ions thiab cov kuab tshuaj organic hauv cov dej khib nyiab. Los ntawm kev siv cov sib nqus sib cais kev ua tau zoo ntawm cov khoom sib nqus, kev sib cais sai thiab tshem tawm cov khoom tsis zoo tuaj yeem ua tiav.
N-Cbz-Nortropinone, raws li cov tshuaj chemical, muaj peev xwm siv tau rau hauv chemistry, pharmaceuticals, thiab lwm yam. Qhov tshwj xeeb kev loj hlob zeem muag ntawm no compound yog raws li nram no:
Trends in Chemical Drug Development
Kev loj hlob muaj zog ntawm cov tshuaj tiv thaiv kab mob
Cov tshuaj tiv thaiv kab mob tau ua kom muaj kev vam meej nyob rau xyoo tas los no, tshwj xeeb tshaj yog nyob rau hauv thaj chaw ntawm oncology. Cov tshuaj tiv thaiv kab mob tshiab xws li monoclonal antibodies (mAbs), antibody tshuaj conjugates (ADCs), thiab bispecific antibodies (BsAbs) tseem tshwm sim, muab cov kev xaiv tshiab rau kev kho mob qog noj ntshav. Kev vam meej thiab kev lag luam daim ntawv thov ntawm cov tshuaj no tsis tsuas yog txhawb txoj kev loj hlob sai ntawm cov tshuaj tiv thaiv kab mob kev lag luam, tab sis kuj tseem muab cov ntaub ntawv siv tau zoo thiab kev tshoov siab rau kev txhim kho lwm yam tshuaj. Rau cov khoom sib xyaw no, yog tias nws tuaj yeem ua haujlwm tseem ceeb hauv nruab nrab lossis cov khoom muaj nyob hauv cov tshuaj tshiab, kev txhim kho muaj zog ntawm cov tshuaj tiv thaiv kab mob tuaj yeem ua rau qee yam kev xav tau ntawm kev lag luam thiab kev tshawb fawb thiab kev loj hlob.
Qhov nce ntawm kev kho ntawm tes thiab kev kho noob caj noob ces
Kev kho mob ntawm tes thiab kev kho noob yog txoj kev kho tshiab uas tau txais kev mloog ntau hauv xyoo tas los. Kev tsim kho tshiab txuas ntxiv thiab kev ua tiav hauv CAR-T cell therapy, TCR-T cell therapy, gene editing technology, etc. tau muab cov tswv yim kho tshiab rau thaj chaw xws li oncology thiab cov kab mob tsawg. Kev nce ntawm cov kev kho tshiab no tsis yog tsuas yog nthuav dav hauv thaj chaw thiab cov tswv yim ntawm kev txhim kho tshuaj, tab sis kuj muab cov neeg mob nrog ntau hom kev kho mob.
Kev ua lag luam xav tau kev txheeb xyuas
Kev nthuav dav ntxiv ntawm kev lag luam kho mob qog noj ntshav
Nrog rau kev laus ntawm cov pej xeem hauv ntiaj teb thiab kev hloov pauv hauv kev ua neej, qhov xwm txheej thiab kev tuag ntawm cov qog nqaij hlav yog nce. Kev lag luam kho mob qog noj ntshav tau nthuav dav tas li, thiab qhov kev thov rau cov tshuaj tshiab, zoo, thiab kev nyab xeeb kuj nce ntxiv. Qhov no muab qhov chaw lag luam dav dav rau kev txhim kho cov tshuaj tiv thaiv kab mob -, suav nrog cov tshuaj no.
Tsis tshua muaj tshuaj rau kev kho mob tsawg
Cov kab mob tsis tshua muaj qhov tsis tshua muaj nyob rau hauv cov nqe lus ntawm cov tshuaj kho mob vim muaj qee yam xws li cov neeg mob tsawg, cov nqi tshawb fawb thiab kev loj hlob siab, thiab kev lag luam qis. Txawm li cas los xij, nrog kev nce qib ntawm kev kho mob thev naus laus zis thiab kev tiv thaiv tus neeg mob txoj cai, kev lag luam thov rau cov tshuaj kho mob tsawg zuj zus zuj zus. Yog tias nws tuaj yeem siv los ua cov khoom tseem ceeb lossis nruab nrab hauv kev kho tus kab mob tsis tshua muaj, nws txoj kev cia siab ntawm kev ua lag luam yuav yog qhov dav dua.
Txhawb nqa tus kheej cov tshuaj thiab cov tshuaj precision
Cov tshuaj kho tus kheej thiab cov tshuaj precision yog qhov tseem ceeb ntawm txoj kev loj hlob ntawm cov tshuaj hauv xyoo tas los no. Los ntawm txoj kev xws li gene sequencing thiab biomarker kuaj, kws kho mob tuaj yeem muab cov neeg mob nrog cov phiaj xwm kho mob ntau dua. Cov qauv no tau tsav qhov kev thov rau kev tsim tshuaj tshiab thiab muab ntau lub sijhawm rau kev siv tshuaj zoo li no.
Kev lag luam xav tau dab tsi rau N-Cbz Nortropinone, tshuaj tiv thaiv kab mob?
Hais txog kev ua lag luam xav tauN-Cbz-Nortropinonetshuaj tiv thaiv kab mob, raws li cov tshuaj no tsis tau lees paub los yog pom nyob rau hauv kev ua lag luam, nws qhov kev xav tau ntawm kev lag luam tuaj yeem raug txheeb xyuas ncaj qha lossis kwv yees los ntawm cov hauv qab no:
Kev kho mob xav tau
Yog tias N-Cbz Nortropinone tshuaj tiv thaiv kab mob yog tsom rau ntawm ib tus kab mob tshwj xeeb, qhov tshwm sim, tus naj npawb ntawm cov neeg mob thiab kev kho mob ntawm tus kab mob yuav cuam tshuam ncaj qha rau kev lag luam xav tau tshuaj. Nws yog ib qho tsim nyog kom nkag siab txog cov yam ntxwv ntawm tus kabmob kis, cov neeg mob, thiab kev kho mob ntawm tus kabmob uas tau tsom los ntawm cov tshuaj txhawm rau txhawm rau ntsuas nws qhov kev xav tau ntawm kev lag luam.
01
Kev siv tshuaj zoo thiab kev nyab xeeb
Kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj yog qhov tseem ceeb rau cov neeg mob thiab kws kho mob thaum xaiv cov tshuaj kho mob. Yog tias cov tshuaj tiv thaiv kab mob pom tau tias muaj txiaj ntsig zoo thiab muaj kev nyab xeeb zoo hauv kev sim tshuaj lossis kev siv tswv yim, nws qhov kev thov kev lag luam yuav nce ntxiv.
02
Kev ua lag luam kev sib tw qauv
Kev sib tw hauv kev lag luam tshuaj tiv thaiv kab mob yog qhov hnyav, thiab muaj cov tshuaj zoo sib xws yuav cuam tshuam ncaj qha rau kev lag luam thiab kev thov rau N-Cbz Nortropine tshuaj tiv thaiv kab mob. Nws yog ib qho tsim nyog kom nkag siab txog hom, kev ua tau zoo, tus nqi, thiab kev sib koom ua lag luam ntawm cov tshuaj zoo sib xws hauv kev ua lag luam txhawm rau ntsuas qhov kev sib tw ntawm cov tshuaj tiv thaiv kab mob no.
03
Txoj cai thiab kev tuav pov hwm kho mob
Cov cai thiab kev tuav pov hwm kho mob muaj feem cuam tshuam rau kev lag luam xav tau tshuaj. Yog tias N-Cbz Nortropinone cov tshuaj tiv thaiv kab mob suav nrog hauv phau ntawv pov hwm kho mob lossis tau txais kev txhawb nqa txoj cai, lawv cov kev xav tau hauv khw yuav nce ntxiv.
04
Kev tsim khoom thiab khoom siv raws li txoj cai
Kev tsim khoom thiab kev xa khoom ntawm cov tshuaj tuaj yeem cuam tshuam rau lawv cov kev xav tau ntawm kev lag luam. Yog tias tus nqi tsim khoom ntawm N-Cbz Nortropinone tshuaj tiv thaiv kab mob siab, cov saw hlau tsis ruaj khov, lossis muaj peev xwm ntau lawm tsis txaus, ces lawv qhov kev thov kev lag luam yuav raug txwv.
05
kev phiv tshuaj
Hauv kev tsim tshuaj lom neeg, Cbz pawg ntawm N-Cbz Nortropinone tuaj yeem raug xaiv tshem tawm hauv cov xwm txheej me (xws li hydrogenolysis lossis acidolysis), tso tawm cov amino pawg dawb thiab muab cov chaw ua haujlwm rau cov tshuaj tiv thaiv tom qab. Nws txoj kev ruaj ntseg thiab kev xaiv cov tshuaj tiv thaiv ua rau nws yog ib qho tseem ceeb hauv nruab nrab ntawm kev tsim tshuaj, xws li rau kev sib txuas ntawm cov tshuaj lom neeg lom neeg tropane derivatives. Txawm li cas los xij, raws li cov tshuaj reagent, nws cov kev cuam tshuam tsis zoo feem ntau tsom rau lub cev thiab tshuaj lom neeg thaum lub sijhawm ua haujlwm, tsis yog tshuaj lom neeg hauv lub cev.
Daim tawv nqaij thiab mucosal irritation
Cov tshuaj tiv thaiv tiv thaiv ncaj qha: Cov hmoov hmoov lossis cov tshuaj N-Cbz Nortropinone tuaj yeem ua rau tawv nqaij thiab qhov muag. Yog tias tus neeg teb xov tooj tsis hnav hnab looj tes lossis looj tsom iav, nws yuav ua rau liab, khaus, lossis mob hauv qhov chaw sib cuag. Piv txwv li, cov khoom uas tau txaws rau ntawm daim tawv nqaij hauv chav kuaj yuav ua rau muaj kev kub ntxhov ntau ntxiv vim kev sib txhuam ntawm cov khoom siv, thaum cov kev daws teeb meem tuaj yeem ua rau cov tawv nqaij cuam tshuam los ntawm permeation.
Kev tsis haum tshuaj: Ib tus neeg tsawg heev tuaj yeem tsim kev tsis haum rau Cbz pawg lossis cov qauv tropane, tshwm sim raws li kev sib cuag dermatitis lossis conjunctivitis. Hom tshuaj tiv thaiv no feem ntau cuam tshuam nrog kev lees paub ntawm cov pab pawg ua haujlwm tshwj xeeb hauv cov khoom sib txuas los ntawm tus neeg lub cev tiv thaiv kab mob thiab yuav tsum tau kuaj xyuas los ntawm kev kuaj kab mob los yog kev kuaj mob ophthalmic.
Inhalation toxicity
Raug rau plua plav thiab vapor: N-Cbz Nortropinone tuaj yeem tsim cov plua plav nqus tau los yog cov vapors volatile thaum sib tsoo, hnyav, lossis cov txheej txheem cua sov. Lub sij hawm ntev raug rau cov plua plav tsis tshua muaj peev xwm ua rau ua pa ua pa, tshwm sim raws li hnoos, mob caj pas, lossis hauv siab nruj; Kev nqus pa ntawm high concentration vapor tuaj yeem ua rau muaj tshuaj lom neeg mob ntsws, tshwj xeeb tshaj yog nyob rau hauv qhov chaw muaj av noo siab uas cov tebchaw yuav hydrolyze los tsim cov metabolites irritating.
Cov mob lom lom heev: Txawm hais tias tsis tshua muaj, kev sim tsiaj tau pom tias kev nqus tau ntau npaum li cas yuav ua rau muaj kev cuam tshuam hauv nruab nrab ntawm lub paj hlwb, tshwm sim raws li kiv taub hau, qaug zog, lossis ataxia, uas cuam tshuam nrog kev cuam tshuam ntawm cov qauv tropine ntawm acetylcholine receptors.
Cov tshuaj tiv thaiv digestive
Kev noj haus lossis kev noj: Txawm hais tias N-Cbz Nortropinone tsis yog cov khoom noj khoom haus, kev noj haus yuav ua rau xeev siab, ntuav, lossis mob plab. Nws cov dej solubility tsawg tuaj yeem txo qis kev nqus ntawm plab hnyuv, tab sis cov koob tshuaj ntau tseem tuaj yeem ua rau lub plab zom mov ncaj qha, ua rau yaig lossis los ntshav.
Metabolite toxicity: Hauv vivo, Cbz pawg yuav raug hydrolyzed los ntawm esterases los tsim benzoic acid thiab carbon dioxide, thaum lub cev pob txha tropane yuav ntxiv metabolized rau hauv tropane acid lossis nws cov derivatives. Txawm hais tias cov metabolites no muaj cov tshuaj toxicity tsawg, cov tib neeg tsawg heev tuaj yeem tsim cov khoom nruab nrab vim cov metabolism hauv cov enzymes (xws li kev ua haujlwm tsis txaus esterase), ua rau lub siab toxicity.
Kev tshwm sim hauv qhov chaw tshwj xeeb
Photosensitivity: Ntev ntev raug rau lub teeb muaj zog tuaj yeem ua rau photodegradation ntawm N-Cbz Nortropinone, tsim cov duab toxic dawb radicals lossis peroxides. Yog tias cov tswv lag luam tuaj rau hauv kev sib cuag nrog cov khoom lag luam photodegradation, nws yuav ua rau cov tawv nqaij photosensitivity tshwm sim, manifested li erythema, edema, los yog pigmentation.
Kub decomposition: Thaum tshav kub kub rau boiling point (kwv yees li 415.7℃C), lub compound yuav decompose los tsim cov pa phem xws li nitrogen oxides, carbon monoxide, los yog benzene derivatives. Nws yog ib qho tsim nyog yuav tsum nruj me ntsis ua haujlwm hauv lub fume hood kom tsis txhob nqus pa.
Cim npe nrov: n-cbz-nortropinone cas 130753-13-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom