Cov mis molecular ntawmnitazoxanide hmoovyog C12H9N3O5S, CAS 55981-09-4, thiab qhov hnyav molecular yog 307.28 g / mol. Nws yog cov dawb dawb dawb crystalline hmoov nrog cov tshuaj npe 2- [(5-nitro-1,3-thiazol-2-yl) carbamoyl] phenol acetate, uas belongs rau cov derivatives ntawm nitrothiazide. Txawm hais tias nws qhov kev ua haujlwm tiag tiag tseem tsis tau meej meej, nws ntseeg tau tias muaj feem xyuam rau cov enzyme dependent electron hloov cov tshuaj tiv thaiv uas inhibits pyruvate thiab hlau redox protein oxidoreductase, tom kawg uas yog qhov tseem ceeb rau anaerobic zog metabolism.
Cov khoom no muaj zog tsis tsuas yog tawm tsam Cryptosporidium thiab Giardia, tab sis kuj tawm tsam ntau cov kab mob hauv plab xws li Babesia thiab lwm yam sporozoites, amoebic protozoa, tib neeg roundworms, hookworms, flagellates, nqaij nyuj tapeworms, luv membrane plhaub tapeworms, thiab daim siab flukes. Nws muaj cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob hauv plab, tshuaj tua kab mob, tshuaj tua kab mob thiab lwm yam tshuaj, thiab nws cov tshuaj tiv thaiv kab mob parasitic thiab tshuaj tua kab mob muaj ntau dua li ntawm albendazole, metronidazole thiab metronidazole, thiab nws daim ntawv thov teb kuj muaj ntau dua li lwm cov tshuaj.
Cov khoom no tseem muaj zog tiv thaiv qee yam kab mob anaerobic thiab microaerophilic, xws li Helicobacter pylori. Raws li ib tsab xov xwm luam tawm nyob rau hauv lub npe nrov British kws kho mob phau ntawv Journal The Lancet thaum Lub Rau Hli 13, 2006, nitrozotocinide kuj muaj txiaj ntsig zoo rau kev mob plab menyuam yaus los ntawm rotavirus.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Nitazoxanide ntsiav tshuaj | Nitazoxanide hmoov |
| Yam khoom | Cov ntsiav tshuaj | Hmoov |
| Khoom Purity | HPLC Ntau dua lossis sib npaug rau 99.0% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable |
| Pob khoom | Customizable | Customizable |
Peb Cov Khoom
Nitazoxanide +. COA
Nitazoxanide hmoov, raws li qhov dav -spectrum antibacterial, anti parasitic, thiab tshuaj tiv thaiv kab mob, ua lub luag haujlwm tseem ceeb hauv kev kho mob. Nws cov qauv tshuaj tshwj xeeb thiab cov txheej txheem ntawm kev ua haujlwm ua rau nws muaj kev xaiv zoo los kho ntau yam kab mob sib kis.
Kev siv tshuaj tiv thaiv kab mob
1.Kev kho mob ntawm Cryptosporidiosis
Nizopanib yog thawj zaug thiab nkaus xwb tshuaj pom zoo los ntawm US Food and Drug Administration (FDA) rau kev kho mob ntawm cryptosporidiosis. Cryptosporidium yog ib qho kab mob hauv plab hnyuv, uas tuaj yeem ua rau raws plab thiab lwm yam tsos mob. Tshwj xeeb tshaj yog rau cov neeg mob uas tsis muaj zog tiv thaiv kab mob, xws li cov neeg mob AIDS, tus kab mob cryptosporidium tuaj yeem ua rau mob raws plab. Nizonide ua tiav cov hom phiaj kho mob los ntawm inhibiting lub zog metabolism hauv Cryptosporidium, cuam tshuam nrog nws txoj kev loj hlob thiab kev loj hlob. Kev tshawb fawb tau pom tias nitrozotocinide muaj cov txiaj ntsig tseem ceeb hauv kev kho mob raws plab los ntawm cryptosporidium, txo cov tsos mob, txo qhov zaus thiab lub sijhawm ua raws plab.
2. Kev kho mob Giardia
Giardia yog lwm yam kab mob plab hnyuv uas tuaj yeem ua rau tus kab mob Giardia, uas yog mob plab, raws plab, xeev siab, ntuav, thiab lwm yam tsos mob. Nizonide muaj zog inhibitory nyhuv ntawm Giardia, thiab nws cov txheej txheem ntawm kev ua yog cuam tshuam nrog inhibition ntawm Giardia 'zog metabolism. Hauv kev sim tshuaj, nitrozotocinide tau pom tias muaj txiaj ntsig zoo hauv kev kho Giardia lamblia, tshem tawm lub cev ntawm Giardia lamblia, txo cov tsos mob, thiab muaj lub siab ntev.
3. Kho lwm yam kab mob hauv plab hnyuv
Nizonide yog nquag tawm tsam ntau yam kab mob hauv plab hnyuv, nrog rau sporozoites xws li Babesia, amoebas, roundworms, hookworms, whipworms, nqaij nyug tapeworms, luv membrane tapeworms, thiab daim siab flukes. Rau cov kab mob tshwm sim los ntawm Bacillus subtilis thiab lwm yam sporozoites, nitrozotocinide tuaj yeem cuam tshuam lawv txoj kev loj hlob thiab kev loj hlob, thiab txo cov tsos mob ntawm tus kab mob. Rau cov kab mob amoebic, nitrozotocinide tuaj yeem cuam tshuam kev loj hlob thiab kev sib kis ntawm cov kab mob amoebic, txo cov kev mob tshwm sim, thiab txo cov tsos mob ntsig txog. Thaum kho cov kab mob hauv plab hnyuv xws li kab mob kab mob sib kis, kab mob sib kis, kab mob npaws, kab mob nqaij nyug, kab mob luv luv tapeworms, thiab kab mob siab, nitrozotinib kuj qhia tau tias muaj txiaj ntsig zoo hauv kev tshem cov kab mob hauv lub cev thiab txhim kho kev noj qab haus huv ntawm cov neeg mob.
4. Kho cov kab mob cab hauv cov menyuam yaus
Nizopanib muaj nuj nqis tseem ceeb hauv kev kho cov kab mob parasitic hauv cov menyuam yaus. Piv txwv li, nyob rau hauv kev kho mob ntawm tus me nyuam kab mob roundworm thiab kab mob tapeworm, nitrozotocinide tuaj yeem muaj cov nyhuv zoo sib xws rau albendazole thiab praziquantel. Nws cov ntaub ntawv ntau npaum li cas, nrog rau cov ntsiav tshuaj thiab cov tshuaj qhuav qhuav, ua kom yooj yim rau cov menyuam yaus hnub nyoog sib txawv. Rau cov menyuam yaus, kev ncua kev qhuav qhuav tuaj yeem pab kho qhov kev noj tshuaj thiab txhim kho kev noj tshuaj. Cov kev tshawb fawb soj ntsuam tau pom tias nitrozotocinide muaj kev nyab xeeb zoo thiab muaj kev cuam tshuam tsawg dua hauv kev kho cov kab mob parasitic hauv cov menyuam yaus. Nws tuaj yeem tshem tawm cov kab mob cab hauv cov menyuam yaus lub cev thiab txhawb lawv txoj kev loj hlob zoo.
Kev siv tshuaj tua kab mob
1. Kho cov kab mob anaerobic
Nitrozotocin nthuav tawm dav -spectrum antibacterial kev ua haujlwm tawm tsam ntau yam kab mob anaerobic, suav nrog Bacteroides fragilis, Clostridium difficile, Campylobacter jejuni, Clostridium difficile, thiab Clostridium perfringens. Cov kab mob anaerobic tuaj yeem ua rau muaj kab mob hauv plab, plab kab noj hniav, qhov ncauj kab noj hniav, thiab qhov chaw mos, ua rau cov tsos mob xws li kev tsim abscess, cov ntaub so ntswg necrosis, thiab tag nrho tsis xis nyob. Nitrozotocin ua tiav cov tshuaj tua kab mob los ntawm inhibiting lub zog metabolism hauv cov kab mob anaerobic, cuam tshuam nrog lawv txoj kev loj hlob thiab kev tsim tawm. Nizopanib tuaj yeem siv ua ke nrog lwm cov tshuaj tua kab mob txhawm rau txhim kho kev kho mob hauv kev kho mob plab thiab plab hnyuv. Rau cov kab mob hauv qhov ncauj, nitazonide tuaj yeem ua rau hauv qhov ncauj lozenges lossis tshuaj ntxuav qhov ncauj, uas tuaj yeem siv ncaj qha rau thaj chaw muaj kab mob kom txo tau cov tshuaj tiv thaiv kab mob. Thaum kho cov kab mob hauv qhov chaw mos, nitrozotocin tuaj yeem ua rau hauv qhov chaw mos los yog ntxuav, tshem tawm cov kab mob anaerobic ntawm qhov chaw mos thiab txo cov tsos mob.
2. Kev kho tus kab mob Helicobacter pylori
Helicobacter pylori yog ib hom kab mob pathogenic hauv plab uas tuaj yeem ua rau muaj kab mob xws li gastritis, gastric ulcers, thiab duodenal ulcers.Nitazoxanide hmoovNws muaj kev ua haujlwm tiv thaiv Helicobacter pylori thiab tuaj yeem cuam tshuam nws txoj kev loj hlob thiab kev loj hlob. Thaum kho tus kab mob Helicobacter pylori, nitrozotocin feem ntau yog siv ua ke nrog lwm cov tshuaj tua kab mob xws li clarithromycin, amoxicillin, thiab lwm yam, tsim ib qho kev kho triple lossis plaub fab. Qhov kev sib xyaw ua ke no tuaj yeem txhim kho qhov kev tshem tawm ntawm Helicobacter pylori thiab txo qhov kev loj hlob ntawm cov tshuaj tiv thaiv. Cov kev tshawb fawb soj ntsuam tau pom tias kev sib xyaw ntawm nitrozotocinide thiab lwm yam tshuaj tua kab mob muaj txiaj ntsig zoo hauv kev kho tus kab mob Helicobacter pylori, txo cov neeg mob cov tsos mob thiab txhawb kev kho mob plab.
3. Kho lwm yam kab mob
Nizopanib kuj muaj qee yam kev kho mob rau qee yam kab mob, xws li pseudomembranous colitis tshwm sim los ntawm Clostridium difficile. Clostridium difficile yog ib hom kab mob plab hnyuv uas tuaj yeem tsim cov co toxins, ua rau cov hnyuv puas tsuaj thiab ua rau muaj kev cuam tshuam. Nizopanib alleviates cov tsos mob ntawm pseudomembranous colitis los ntawm inhibiting kev loj hlob thiab kev loj hlob ntawm Clostridium difficile, txo cov co toxins. Thaum cov txheej txheem kho mob, nitrozotocinide tuaj yeem siv ua ke nrog lwm cov tshuaj los txhim kho kev kho mob thiab txo cov kab mob.
Kev siv tshuaj tua kab mob
1. Kev kho mob rotavirus gastroenteritis
Rotavirus yog ib qho ntawm cov kab mob tseem ceeb ua rau mob plab hnyuv hauv cov menyuam yaus, uas tuaj yeem ua rau cov tsos mob hnyav xws li raws plab, ntuav, thiab lub cev qhuav dej. Nizopanib muaj kev kho mob zoo ntawm rotavirus gastroenteritis. Kev tshawb fawb tau pom tias nitrozotocinide tuaj yeem cuam tshuam kev rov ua dua ntawm rotavirus, txo cov hnyuv mob los ntawm kev kis kab mob, thiab txo cov tsos mob xws li raws plab thiab ntuav. Hauv kev sim tshuaj, kev siv nitrozotocinide los kho cov menyuam yaus uas muaj tus kab mob rotavirus gastroenteritis ua rau lub sij hawm luv rau cov tsos mob thiab cov kab mob, thiab kev kho mob tseem ceeb.
2. Kev kho kab mob siab C
Nixostat kuj tau qhia txog qee yam kev kho mob ntawm tus kab mob siab C. Nws cov metabolite, Tenzomib, muaj qhov tshwj xeeb inhibitory nyhuv ntawm HCV replication. Multicenter ob - qhov muag tsis pom kev randomized tswj kev sim tshuaj xyuas qhov ua tau zoo ntawm nitazonide hauv kev kho mob siab C ntev, nrog kev kho mob ntawm nitazonide 500mg po bid lossis placebo rau 24 lub lis piam. Raws li qhov tshwm sim, thaum kawg ntawm kev kho mob, HCV RNA seroconversion tus nqi hauv pawg nitrozotocinide thiab placebo pawg yog 30.4% (7/23) thiab 0% (0/24), feem; Tom qab 24 lub lis piam ua raws- tom qab kev kho mob, qhov kev hloov pauv tsis zoo ntawm HCV RNA hauv pawg nitrozotocinide yog 17.4% (4/23). Qhov no qhia tau hais tias nitrendipine muaj qee yam peev xwm hauv kev kho mob ntawm tus kab mob siab C ntev, vim nws tuaj yeem txo cov kab mob thiab txhim kho kev kho tus nqi ntawm cov neeg mob.
3. Inhibition ntawm lwm yam kab mob
Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tau pom tias nitazone kuj muaj kev cuam tshuam rau qee yam kab mob, xws li kab mob khaub thuas, kab mob coronavirus, thiab lwm yam. Hauv cov qauv tsiaj, nitrozotocinide tau qhia txog kev tiv thaiv tus kab mob Japanese encephalitis, txo qis tus neeg tuag ntawm cov nas thiab tiv thaiv lawv los ntawm kev sib tw tua kab mob. Txawm hais tias tam sim no muaj kev tshawb fawb me me ntawm cov teebmeem ntawm nitrozotocinide ntawm cov kab mob no, cov kev tshawb pom no muab cov tswv yim tshiab thiab cov lus qhia rau kev siv nitrozotocinide hauv kev kho tshuaj tiv thaiv kab mob.
Lwm yam kev siv tau
1. Regulating autophagy thiab inhibiting mTORC1 signaling
Nizopanib tseem tuaj yeem tswj hwm autophagy thiab inhibit mTORC1 signaling. Autophagy yog cov txheej txheem intracellular degradation uas ua lub luag haujlwm tseem ceeb hauv kev tswj kev ruaj ntseg ntawm cellular ib puag ncig thiab kev ciaj sia ntawm cov hlwb. Txoj kev taw qhia mTORC1 ua lub luag haujlwm tseem ceeb hauv cov txheej txheem xws li kev loj hlob ntawm tes, kev loj hlob, thiab cov metabolism. Nizopanib tuaj yeem muaj cov teebmeem kev kho mob ntawm qee cov kab mob ntsig txog kev loj hlob ntawm tes thiab metabolic abnormality, xws li qog, los ntawm kev tswj autophagy thiab inhibiting mTORC1 signaling. Txawm li cas los xij, kev tshawb fawb tam sim no ntawm lub luag haujlwm ntawm nitrozotocinide nyob rau hauv cov cheeb tsam no tseem nyob rau theem pib, thiab xav tau kev tshawb fawb ntxiv los nthuav qhia nws cov txheej txheem tshwj xeeb ntawm kev ua haujlwm thiab cov peev txheej siv tshuaj kho mob.
2. Kev kho kab mob siab B
Cov kev tshawb fawb tau pom tias nitazone kuj pom zoo inhibition ntawm HBV replication. Nixostat induces ib tug txo nyob rau hauv zus tau tej cov HBV proteins (HBsAg thiab HBeAg, core antigens) nyob rau hauv 2.2.15 hlwb, tab sis tsis cuam tshuam rau transcription ntawm HBV RNA. Qee qhov kev tshawb fawb ua ntej qhia tau hais tias qhov tsis zoo hloov pauv ntawm HbeAg thiab HBsAg hauv kev kho kab mob siab B nrog Nizoxanide yog qhov siab dua li lwm cov tshuaj kho mob siab B, suav nrog interferon. Qhov no qhia tiasNitazoxanide hmoovtej zaum yuav muaj peev xwm thov kev cia siab rau hauv kev kho kab mob siab B, tab sis xav tau kev sim tshuaj ntau ntxiv los xyuas nws cov txiaj ntsig thiab kev nyab xeeb.
Polycrystalline phenomenon
Cov khoom no muaj nyob rau hauv ob daim ntawv siv lead ua: crystal form I melts ntawm 198℃C, thiab siv lead ua daim ntawv II melts ntawm 201℃C. Muaj qhov sib txawv txav ntawm 2 cm ⁻ ¹ nyob rau hauv ester carbonyl stretching vibration ncov ntawm lub infrared spectra ntawm ob daim ntawv siv lead ua ntawm 1720 cm ⁻ ¹. Kev tshawb fawb txog kev hloov pauv siv lead ua tau pom tias cov siv lead ua ntshiab kuv tuaj yeem tau txais los ntawm recrystallization hauv ethanol tov, thaum siv lead ua daim ntawv II nyhav rau hauv ethyl acetate. Kev soj ntsuam nruj ntawm daim ntawv siv lead ua yog qhov yuav tsum tau ua hauv kev tsim kho, vim tias qhov kev sib cais ntawm cov siv lead ua daim ntawv II yog 15-20% qis dua li cov siv lead ua daim ntawv I.
Lub peev xwm ntawm cov khoom no nkag mus rau lub ntsej muag crystal barrier ntawm Natron ntsev (Na2CO3 · NaHCO3)
Trona (Na ₂ CO ∝ · NaHCO ∝) yog ib yam khoom uas tshwm sim los ntawm carbonate bicarbonate composite ntxhia, nws cov qauv crystalline tuaj yeem ua rau lub cev tsis muaj zog uas cuam tshuam rau permeability ntawm cov tshuaj molecules. Nitazoxanide (NTZ) yog ib qho dav -spectrum antiparasitic thiab tshuaj tiv thaiv kab mob, thiab nws daim ntawv hmoov yuav tsum tau nkag mus rau cov teeb meem siv lead ua no hauv cov xwm txheej tshwj xeeb, xws li kev kho mob hauv zos ntawm cov kab mob ntsev hauv pas dej los yog kev txhim kho kev siv tshuaj.
Cov yam ntxwv ntawm Trona Crystal Barrier
Crystal Structure
Cov qauv siv lead ua ntawm Trona belongs rau monoclinic system, nrog rau pawg C2 / c. Nws cov lattice yog tsim los ntawm Na ⁺, CO ∝ ² ⁻, thiab HCO ∝ ⁻ ions txuas nrog ionic thiab hydrogen bonds los tsim cov txheej txheem txheej (Daim duab 1). Txhua txheej yog alternated nrog Na ⁺ thiab CO ∝ ² ⁻ / HCO ∝⁻, thiab ruaj khov lub cev tsis sib haum yog tsim los ntawm cov khaubncaws sab nraud povtseg los ntawm hydrogen bonding thiab van der Waals rog sib cuam tshuam. Cov qauv no endows Natron ntsev nrog cov yam ntxwv hauv qab no:
Siab mechanical zog: Interlayer rog ua rau nws nyuaj rau cov crystals kom lub cev tawg.
Tsawg permeability: Molecules yuav tsum tau kov yeej interlayer zog teeb meem kom nkag mus rau qhov thaiv.
Environmental responsiveness: Hloov cov av noo, qhov kub thiab txias, lossis pH tuaj yeem hloov pauv crystal morphology thiab cuam tshuam rau kev ua haujlwm tsis zoo.
Crystal morphology thiab barrier muaj nuj nqi
Lub crystalline morphology ntawm Trona (xws li particle loj thiab morphology) ncaj qha cuam tshuam rau permeability ntawm barrier:
Microcrystalline (<10 μ m): with a large specific surface area, numerous interlayer gaps, and high permeability.
Large crystals (>100 μ m): have a dense structure and low permeability, but may provide permeation channels due to cracks or defects.
Porous qauv: Los ntawm synthesizing los yog ib txwm tsim pores (xws li mesopores thiab macropores), permeability tuaj yeem txhim kho tau zoo.
FAQ
1. Dhau li ntawm kev tiv thaiv kab mob -kev kho kab mob parasitic, dab tsi yog qee qhov kev tshawb fawb tawm tshiab?
Kev tshawb fawb tau pom tias nws muaj nyob rau hauv vitro inhibitory cuam tshuam rau ntau yam kab mob (xws li rotavirus, norovirus, thiab kab mob khaub thuas). Cov txheej txheem tseem ceeb nyob hauv kev cuam tshuam nrog tus tswv tsev cell's enzyme system, yog li inhibiting tus kab mob replication. Txawm li cas los xij, daim ntawv thov no tseem nyob rau theem tshawb fawb thiab tseem tsis tau muaj daim ntawv thov kev kho mob niaj hnub.
2. Vim li cas ho tsis tsuas yog siv cov hmoov, tab sis yuav tsum tau tsim nws rau hauv kev npaj?
Cov tshuaj no tsis tshua muaj insoluble hauv dej thiab muaj qhov ncauj bioavailability tsawg heev. Nws tsuas tuaj yeem nqus tau zoo los ntawm tib neeg lub cev los ntawm cov txheej txheem tshuaj tshwj xeeb (xws li ua rau hauv cov khoom siv micronized lossis cov ntaub ntawv siv lead ua tshwj xeeb) thiab los ntawm kev ntxiv cov khoom ntxiv. Noj cov hmoov nyoos ncaj qha yog tsis muaj txiaj ntsig thiab ua rau muaj kev pheej hmoo.
3. Qhov kev txwv loj tshaj ntawm daim ntawv thov no yog dab tsi?
Nws txoj kev ua tau zoo yog nyob ntawm tus neeg mob lub cev tsis muaj zog. Raws li cov tshuaj tiv thaiv kab mob / kab mob, nws feem ntau ua haujlwm los ntawm kev ua kom tsis muaj zog ntawm cov kab mob, tsim lub qhov rais rau lub cev tiv thaiv kab mob kom tshem tau tus kab mob. Yog li ntawd, nws muaj kev txwv tsis pub siv rau cov neeg mob uas muaj kev tiv thaiv kab mob hnyav, thiab tsis muaj feem xyuam rau cov kab mob.
Cim npe nrov: nitazoxanide hmoov, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom