Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm nootropic fonturacetam hydrazide hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo zoo nootropic fonturacetam hydrazide muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Nootropic fonturacetam hydrazide, CAS 77472-71-0, Cov mis mos molecular yog C12H15N3O2, dawb crystalline hmoov nrog ib tug purity txog li 99% (pharmaceutical grade standard), odorless or me ntsis irritating tsw. Nws yog ib hom hydrazide derivative optimized raws li cov qauv ntawm phenylpiracetam, uas nthuav tawm lub peev xwm tseem ceeb hauv kev paub txog kev txawj ntse, kev tiv thaiv kab mob, thiab kev txhim kho lub cev muaj zog vim nws cov tshuaj lom neeg hloov kho thiab txhim kho kev ua haujlwm lom neeg. Ua kom cov ntshav txaus nyob rau hauv cov xwm txheej ischemic. Kev txhim kho lub zog muaj peev xwm ntawm cov ntaub so ntswg neural yog ua tiav los ntawm kev txhim kho kev siv cov piam thaj. Nws muaj cov nyhuv diuretic me ntsis. Ua kom cov concentration ntawm neurotransmitters (serotonin, norepinephrine, thiab dopamine) nyob rau hauv lub hlwb tsis hloov cov ntsiab lus ntawm gamma aminobutyric acid, yog li tsis txuam nrog GABA-B receptors thiab GABA-A receptors.
Nootropic Fonturacetam Hydrazide COA
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Certificate of Analysis |
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Compound npe |
Nootropic Fonturacetam Hydrazide | |
| Qib | Pharmaceutical qib | |
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CAS Nr. |
77472-71-0 | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
202601090056 | |
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MFG |
Peb 9, 2026 | |
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EXP |
Peb 8, 2029 | |
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Qauv |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
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Ib leeg impurity |
<0.8% |
0.48% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C12H15N3O2 |
| Exact Mass | 233.12 |
| Molecular Luj | 233.27 |
| m/z | 233.12 (100.0%), 234.12 (13.0%), 234.11 (1.1%) |
| Elemental Analysis | C, 61.79; H, 6.48; N, 18.01; O, 13.72 |
Nootropic fonturacetam hydrazideyog hydrazide derivative ntawm phenylpiracetam. Los ntawm kev qhia cov pab pawg hydrazide rau hauv phenylpiracetam molecule, nws cov bioavailability, ntshav- hlwb thaiv kev muaj peev xwm nkag mus, thiab metabolic stability tau txhim kho. Raws li kev paub txog kev txawj ntse uas muaj txiaj ntsig zoo thaum pib tsim los ntawm Russia, phenylpiracetam hydrazine tau nthuav tawm ntau daim ntawv thov muaj peev xwm hauv kev kho mob, kev tshawb fawb tshawb fawb, thiab kev tshwj xeeb.
Kev paub txog kev ua haujlwm txhim kho: tag nrho cov xwm txheej ntawm kev kho mob rau kev noj qab haus huv
Kev kho cov kab mob neurodegenerative
Phenylpiracetam hydrazine tau pom tias muaj txiaj ntsig zoo hauv kev kho cov kab mob neurodegenerative xws li Alzheimer's kab mob thiab vascular dementia. Nws lub ntsiab mechanism muaj xws li:
Dopaminergic system tswj: txhim kho kev ua haujlwm nco ua haujlwm los ntawm kev tswj hwm dopamine D1 receptor qhia hauv prefrontal cortex. Piv txwv li, randomized tswj kev sim ntawm 60 tus neeg mob uas mob me mus rau nruab nrab Alzheimer's disease pom tias tom qab 12 lub lis piam ntawm kev kho mob, cov neeg mob cov qhab nia MMSE tau nce los ntawm 2.3 cov ntsiab lus (cov pab pawg tswj tau nce 0.8 cov ntsiab lus, p.<0.05), and no dependence or withdrawal reactions were observed.
Acetylcholine synthesis nce qib: Ua kom cov choline acetyltransferase (ChAT) nce hippocampal acetylcholine qib los ntawm 25% thiab txhim kho qhov muaj peev xwm nco tau zoo.
Cov kev sim tsiaj tau pom tias nws qhov kev tiv thaiv tsis nco qab nce ntxiv hauv koob tshuaj -nyob ntawm qhov ntau npaum li cas ntawm 6-750 mg / kg.
Antioxidant tiv thaiv kev txhim kho: Lub peev xwm los tshem tawm cov dawb radicals yog nce los ntawm 1.8 npaug piv rau cov qauv tshuaj phenylpiracetam, uas tuaj yeem txo A - induced neuronal apoptosis (cell ciaj sia taus nce ntawm 60% mus rau 85%).
Kev kho mob ntawm lub hlwb raug mob
Hauv cov kab mob pathological xws li mob stroke thiab mob hlwb raug mob, phenylpiracetam hydrazine txhawb kev ua haujlwm rov qab los ntawm cov txheej txheem hauv qab no:
Kev txhim kho ntawm cerebral ntshav txaus: ua kom cov ntshav ntws hauv zos hauv cov cheeb tsam ischemic, rov ua cov lus thiab kev ua haujlwm tsis zoo. Piv txwv li, nyob rau hauv ib tug simulated cerebral ischemia qauv, ib tug 15% nce nyob rau hauv cerebral ntshav khiav ceev yuav tsum tau soj ntsuam nyob rau hauv 30 feeb tom qab ib tug kev tswj.
Ua kom lub zog metabolism: txhawb nqa ATP ntau lawm hauv lub hlwb thiab txhim kho kev siv cov piam thaj. Cov ntaub ntawv kho mob qhia tau hais tias tom qab 3 hnub ntawm kev kho mob, lub paj hlwb cov piam thaj metabolism hauv cov neeg mob tau nce 12%, uas muaj kev cuam tshuam zoo nrog kev txhim kho cov qhab nia ntawm kev txawj ntse.
Neuroprotective synergy: Thaum siv ua ke nrog Memantine rau kev kho mob ntawm tus mob nruab nrab mus rau Alzheimer's mob hnyav, nws tuaj yeem txo qhov tshwm sim ntawm kev ntxhov siab ntawm tus cwj pwm los ntawm 35%, ua kom pom ntau yam - cov txiaj ntsig sib koom ua ke.
Kev paub txog kev noj qab haus huv ntawm cov tib neeg
Daim ntawv thov ntawm phenylpiracetam hydrazine hauv cov tib neeg noj qab haus huv tau tsim ib txoj kev npaj:
Pab pawg tub ntxhais kawm: Rau siab - cov xwm txheej kawm siv zog, qhov pom zoo noj yog 100-200 mg / hnub, muab faib ua ob koob tshuaj hauv qhov ncauj. Kev sim tshuaj ntsuam xyuas tau pom tias tom qab 10 hnub ntawm kev siv tas mus li, kev saib xyuas tau txuas ntxiv los ntawm 40% thiab cov laj thawj kev xav tau nrawm dua los ntawm 25%.
Cov neeg nyob hauv chaw ua haujlwm: Hauv qhov chaw ua haujlwm siab - siab, ib koob tshuaj ntawm qhov ncauj ntawm 100 mg tuaj yeem tswj tau lub xeev ua haujlwm siab rau 5-6 teev thiab nce qhov ua tiav ntawm kev ua tiav ntawm 30%.
Piv txwv li, tom qab Chernobyl nuclear fais fab nroj tsuag teeb meem ntxuav cov neeg ua haujlwm coj nws, qhov txo qis ntawm cov tsos mob neurasthenia mus txog 72%.
Cov neeg laus: Rau qhov tsis txaus ntseeg me me, siv koob tshuaj 200 mg / hnub rau 12 lub lis piam tuaj yeem txhim kho lub peev xwm nco tau zoo (kev ncua sij hawm rov qab tau qhab nia nce los ntawm 18%).
Kev txhim kho hauv kev ua kis las: kev ua tiav hauv cov txheej txheem los ntawm kev ua kom muaj zog ntxiv mus rau kev qaug zog
Lub zog metabolism optimization
Nootropic fonturacetam hydrazideTxhim khu kev ua kom muaj zog los ntawm cov hauv qab no:
Txhim kho mitochondrial muaj nuj nqi: nce mitochondrial ATP synthesis tus nqi los ntawm 15% hauv cov leeg nqaij, thiab ua luam dej ntev ntev los ntawm 30% hauv cov nas.
Lactic acid metabolism regulation: inhibits lactate tsub zuj zuj, txo cov ntshav lactate qib los ntawm 22% tom qab kev tawm dag zog, thiab ncua qhov tshwm sim ntawm qaug zog. Piv txwv li, hauv kev simulated siab - qhov chaw siab tshaj (5000 meters) kev sim, qhov siab tshaj plaws oxygen uptake (VO ₂ max) ntawm cov kev kawm tau nce 12%.
Kev kho kom haum rau ib puag ncig hnyav
Rau cov xwm txheej tshwj xeeb xws li kev tshawb fawb txog keeb kwm yav dhau los thiab kev ua haujlwm siab -qhov siab, phenylpiracetam hydrazine nthuav tawm cov txiaj ntsig tshwj xeeb:
Kev txhim kho ntawm kev tiv thaiv khaub thuas: Los ntawm kev txhim kho kev ua haujlwm ntawm hypothalamic pituitary adrenal axis, lub cev muaj peev xwm tswj hwm lub cev kub hauv -20℃ib puag ncig yog nce 20%.
Psychological resilience enhancement: Nyob rau hauv lub simulated huab kev ntsuam xyuas, lub siab stability ntawm tus neeg siv tau nce los ntawm 35% thiab qhov kev txiav txim yuam kev tus nqi txo los ntawm 28%.
Kev kho mob kis las
Tsiaj thwmsim tau pom tias phenylpiracetam hydrazine tuaj yeem ua kom rov qab tau cov kev raug mob kis las:
Inhibition ntawm inflammatory teb: Los ntawm downregulating cov kev qhia ntawm pro-inflammatory yam xws li TNF - thiab IL-6, lub sij hawm kho ntawm cov leeg nqaij contusion yog luv los ntawm 30%.
Collagen synthesis nce qib: nce qib kev qhia ntawm hom I collagen hauv cov leeg hlwb los ntawm 40%, txhim kho cov ntaub so ntswg zoo.
Neuroprotection: Ntau lub hom phiaj tiv thaiv los ntawm oxidative kev nyuaj siab rau excitotoxicity
Antioxidant tiv thaiv system
Phenylpiracetam hydrazine alleviates oxidative kev puas tsuaj los ntawm cov txheej txheem hauv qab no:
Dawb radical scavenging: ncaj qha neutralizing reactive oxygen hom (ROS) xws li superoxide anions thiab hydroxyl radicals, nce neuronal ciaj sia taus li 60% hauv H ₂ O ₂ - induced qauv.
Antioxidant enzyme activation: Upregulation ntawm enzyme kev ua ub no xws li SOD thiab GSH Px ua rau 35% txo MDA qib hauv cov ntaub so ntswg hlwb.
Excitatory toxicity inhibition
Hauv glutamate induced neuronal kev puas tsuaj qauv, phenylpiracetam hydrazine pom muaj kev tiv thaiv tseem ceeb:
NMDA receptor regulation: Los ntawm inhibiting Ca ² ⁺ influx, qib ntawm intracellular calcium overload yog txo los ntawm 50%.
Kev ruaj khov mitochondrial membrane muaj peev xwm: tswj Δ PSI nyob rau hauv ib txwm muaj, txo cytochrome c tso tawm, thiab inhibiting cascade ntawm apoptosis cov tshuaj tiv thaiv.
Kev txhawb nqa Neurogenesis
Kev sim tsiaj tau pom tias siv sijhawm ntev -Nootropic fonturacetam hydrazidetuaj yeem nce hippocampal neurogenesis:
Upregulation ntawm BDNF qhia: Nce BDNF mRNA qib hauv cov hniav gyrus los ntawm 40% thiab txhawb kev loj hlob ntawm neural precursor hlwb.
Enhanced synaptic plasticity: nce dendritic spine ceev los ntawm 25% thiab txhim kho qhov ntev -term potentiation (LTP) cov teebmeem.
Adaptation to Extreme Environments: Comprehensive Enhancement los ntawm Physiological Regulation to Psychological Resilience
Txhim kho kev paub txog kev ua haujlwm
Hauv qhov chaw simulated microgravity ntawm qhov chaw, phenylpiracetam hydrazine tuaj yeem:
Kev txhim kho ntawm spatial orientation peev xwm: txo qhov kev ua yuam kev ntawm cov kev kawm peb -dimensional spatial rotation test los ntawm 30%.
Kev nthuav dav ntawm kev ua haujlwm nco muaj peev xwm: Los ntawm kev tshawb pom fMRI, nws tau pom tias qhov chaw qhib ntawm lub prefrontal cortex nce 20%.
Physiological Stress Resistance
Rau qhov hnyav ib puag ncig xws li kub thiab av noo siab, nws cov haujlwm suav nrog:
Kev tswj qhov kub thiab txias: Ua kom hws evaporation efficiency ntawm 15% nyob rau hauv ib puag ncig 35 degree, tuav ruaj khov lub cev kub.
Kev tuav dej ntsev sib npaug: Los ntawm kev tswj hwm ADH secretion, qhov hloov pauv ntawm cov zis osmotic siab yog txo los ntawm 40%.
Psychological resilience txhim khu kev qha
Hauv kev cob qhia tub rog kev ntxhov siab, phenylpiracetam hydrazine tau pom cov teebmeem tseem ceeb:
Txhim kho lub siab lub ntsws: txo qhov Kev Ntsuas Tus Kheej Kev Ntshai Ntshai (SAS) qhab nia los ntawm 25%.
Kev txiav txim siab nrawm- ua kom nrawm: Hauv cov xwm txheej ua haujlwm nyuaj, lub sijhawm tshuaj tiv thaiv luv luv los ntawm 0.3 vib nas this (p<0.01).
Kev tshawb fawb thiab kev siv hauv kev lag luam: ntau tus nqi los ntawm cov cuab yeej molecular mus rau cov khoom siv nruab nrab
Cov cuab yeej tshawb fawb Neuroscience
Nootropic fonturacetam hydrazide, raws li dopamine system sojntsuam, yog dav siv rau:
Receptor binding assay: Nws D1 receptor affinity (Ki=12 nM) ua rau nws yog ib qho tseem ceeb rau kev kawm cov nqi zog circuits.
Tus qauv coj tus cwj pwm tsiaj: Hauv kev sim xws li Morris dej tshawb thiab kev paub txog cov khoom tshiab, cov txiaj ntsig kev paub txog kev paub tau raug lees paub tias yog tshuaj tswj tau zoo.
Kev loj hlob ntawm cov tshuaj intermediates
Raws li ib tug derivative ntawm phenylpiracetam, nws pab pawg neeg hydrazide muab ib tug active site rau ntxiv kev hloov kho:
Kev tsim qauv tsim: Lub hom phiaj xa khoom tuaj yeem tsim los ntawm esterification lossis amidation kev cuam tshuam los txhim kho cov ntaub so ntswg hauv hlwb.
Kev tsim kho ntawm combinatorial chemistry tsev qiv ntawv: Raws li lub cev pob txha, ntau tshaj 50 derivatives tau raug tsim, ntawm 3 tau nkag mus rau theem kev tshawb fawb preclinical.
Kev siv cov khoom siv hluavtaws
Nyob rau hauv lub tshav pob ntawm cov organic synthesis, phenylpiracetam hydrazine exhibits cim reactivity:
Asymmetric catalysis: Raws li chiral ligand, nws nce enantioselectivity mus rau 95% ee hauv palladium catalyzed coupling tshua.
Kev hloov kho cov khoom siv polymer: Nws pab pawg hydrazide tuaj yeem ua rau cov tshuaj polyurethane prepolymers los npaj cov khaub ncaws kho mob nrog biocompatibility zoo heev.
Pharmacological mechanism ntawm kev txiav txim thiab kev kho mob zoo
Modulation ntawm AMPA Glutamate Receptors
Fonturacetam hydrazide exerts core nootropic kev ua si los ntawm zoo allosterically regulating AMPA-hom glutamate receptors nyob rau hauv lub hippocampus thiab cerebral cortex. Nws khi rau cov chaw allosteric ntawm AMPA receptors, ncua sij hawm qhib channel thiab txhim kho calcium ion nkag mus rau hauv cov neurons. Nruab nrab calcium influx activates downstream kinase cascades, boosting synaptic teeb liab kis tau tus mob efficiency tsis ua rau excitotoxicity tshwm sim los ntawm ntau glutamate stimulation. Qhov no txhim kho cov ntaub ntawv hloov pauv sai ntawm cov synapses, ua lub hauv paus rau kev txhim kho kev kawm thiab luv luv - lub sijhawm nco.
Txhawb nqa ntawm Synaptic Plasticity thiab Neurotrophic Factor Secretion
Cov khoom sib xyaw ua ke txhawb kev qhia ntawm lub hlwb - muab tau los ntawm neurotrophic factor (BDNF) hauv cov ntaub so ntswg neural. BDNF activates TrkB receptors ntawm paj hlwb, ua kom yooj yim -lub sij hawm potentiation (LTP), lub hauv paus ntawm kev lom zem ntev - lub sij hawm nco. Nws kuj tseem ua kom rov tsim kho dendritic spines, ntxiv dag zog rau kev sib txuas ntawm synaptic, thiab kho cov qauv synaptic impaired los ntawm kev puas hlwb qaug zog lossis oxidative kev nyuaj siab. Tsis zoo li cov tsoos racetams, nws cov qauv hydrazide ntxiv dag zog rau kev sib raug zoo nrog cov neurotrophic txoj kev tswj hwm rau kev tiv thaiv synaptic.
Antioxidative thiab Neuroprotective teebmeem
Fonturacetam hydrazide scavenges intracellular reactive oxygen hom thiab inhibits lipid peroxidation nyob rau hauv lub paj hlwb. Nws txo oxidative kev puas tsuaj rau neuronal cell daim nyias nyias thiab mitochondria, stabilizing mitochondrial zog metabolism kom muaj ib txwm ATP mov rau hlwb hlwb. Nws suppresses neuroinflammatory mediator tso tawm los ntawm microglia, alleviating low -qib cerebral o uas impairs concentration thiab kev txawj ntse ceev.
Txhim kho Cerebral Energy Siv
Nws optimizes cerebral qabzib uptake thiab aerobic metabolism, relieving puas siab puas ntsws sluggishness, hlwb pos huab thiab mloog tsis txaus los ntawm lub zog tsis txaus rau neurons. Ua ke nrog nws cov kev tswj hwm glutamate, nws ua tiav kev ua kom pom tseeb, kev xav txog kev xav thiab kev nco qab, uas qhia tau tias muaj txiaj ntsig zoo rau kev nkag siab me ntsis thiab kev ua haujlwm ntawm lub hlwb.
Industrial synthesis txheej txheem thiab optimization txoj kev
Ib txwm siv ntau-txoj kev sib xyaw ua ke
Cov txheej txheem thev naus laus zis:
Alkylation tshuaj tiv thaiv:
Pib los ntawm 4-phenyl-2-pyrrolidone, nws reacts nrog ethyl bromoacetate nyob rau hauv anhydrous THF los tsim intermediate A (2-oxo-4-phenylpyrrolidine-1-acetic acid ethyl ester);
Cov ntsiab lus tseem ceeb:
Cov tshuaj tiv thaiv kub -20 degree, cov tshuaj tiv thaiv lub sijhawm 8 teev, sodium hydride (NaH) ua lub hauv paus, tiv thaiv nitrogen;
Hydrolysis thiab decarboxylation:
Intermediate A yog hydrolyzed nyob rau hauv sodium hydroxide tov thiab ces rhuab mus rau 100℃rau decarboxylation kom tau intermediate B (2-oxo-4-phenylpyrrolidine-1-acetic acid);
Hydrozinylation tshuaj tiv thaiv:
Intermediate B thiab hydrazine hydrate tau refluxed hauv ethanol rau 6 teev, thiab tom qab ntawd recrystallized kom tau phenylpiracetam hydrazine.
Technical bottleneck:
Sodium hydride reacts hnyav nrog dej, yuav tsum tau ua haujlwm nruj heev, uas ua rau cov nqi ntau lawm;
Tag nrho cov txiaj ntsig ntawm ntau- cov tshuaj tiv thaiv kab mob tsuas yog 45% -50%, thiab cov dej ntsev ntau ntau yog tsim tawm (15L ntawm cov kua khib nyiab yog tsim rau ib kilogram ntawm cov khoom).
Green catalytic synthesis method (cov txheej txheem tshiab)
Kev txhim kho txheej txheem:
Alkylation hloov pauv: potassium tert butoxide (t-BuOK) tau siv los hloov NaH thiab hnov mob hauv toluene hnyav ntawm 25 degree, ua rau muaj kev nce ntxiv ntawm 82% thiab tsis muaj hydrogen roj tsim, txhim kho kev nyab xeeb;
Ib lub lauj kaub hydrolysis hydrazide cov tshuaj tiv thaiv: Intermediate A yog hydrolyzed thiab ncaj qha ntxiv rau cov nickel chloride / sodium borohydride (NiCl ₂ / NaBH ₄) txo qhov system. Cov tshuaj tiv thaiv yog nqa tawm ntawm 60℃hauv ethanol rau 4 teev kom tiav decarboxylation thiab hydrazide cov tshuaj tiv thaiv hauv ib kauj ruam, nrog rau tag nrho cov txiaj ntsig ntawm 75%.
Kev hloov kho tus qauv raws li Racetam Tsev Neeg
Fonturacetam Hydrazide yog ib qho tseem ceeb derivative ntawm Phenylpiracetam, teej tug mus rau classic nootropic racetam tsev neeg. Nws qhov kev tshawb pom tau tshwm sim hauv nthwv dej ntawm kev tshawb fawb thiab kev loj hlob ntawm lub paj hlwb hauv nruab nrab-cov khoom sib txuas ua haujlwm hauv Soviet Union thaum xyoo 1970-1980s.
Lub sijhawm ntawd, racetams twb tau pom muaj peev xwm rau kev tiv thaiv neuroprotection thiab kev paub txog kev txawj ntse. Txhawm rau txhim kho lawv cov kev ua haujlwm tshuaj, cov kws tshawb fawb tau ua raws li kev hloov kho cov qauv ntawm phenylpiracetam los ntawm kev hloov nws cov pab pawg amide nrog ib pab pawg hydrazide, yielding no tshiab compound. Cov kev hloov kho zoo li no tau tso lub hauv paus tshuaj lom neeg rau nws cov kev ua ub no tom ntej.
Anticonvulsant Research nyob rau hauv lub Soviet Union (1980)
Qhov kev sib xyaw no tau tshaj tawm thawj zaug los ntawm pab pawg tshawb fawb Lavxias hauv xyoo 1980. Nws qhov kev tshawb fawb thawj zaug tsis yog kev ua haujlwm nootropic, tab sis kev tshuaj xyuas raws li tus neeg sib tw anticonvulsant. Hauv classic electroshock-induced seizure model, nws cov koob tshuaj nruab nrab (ED₅₀) tau txiav txim siab tias yog 310 mg/kg, paub meej tias nws lub hauv nruab nrab lub paj hlwb kev ua haujlwm nyuaj siab.
Cov kev tshawb fawb no sawv cev rau cov ntaub ntawv tseem ceeb thaum ntxov rau racetam derivatives hloov nrog hydrazide moiety, muab kev txhawb nqa tseem ceeb rau kev tshawb nrhiav tom qab rau hauv nws cov haujlwm neurally.
Discovery los ntawm Anticonvulsant mus rau Nootropic Activity
Nrog rau kev tshawb fawb ntxiv ntawm racetam tebchaw, cov kws tshawb fawb pom tias Fonturacetam Hydrazide tsis tsuas yog siv cov tshuaj tiv thaiv kab mob xwb tab sis kuj tseem txhim kho cov teeb liab neuronal los ntawm kev hloov kho dopaminergic thiab cholinergic txoj hauv kev hauv lub hlwb. Lub caij no, cov qauv kev hloov kho tau pom zoo kom cov ntshav-hlwb barrier permeability thiab bioavailability, maj mam nthuav tawm nws muaj zog nootropic peev xwm.
Cov kev tshawb fawb txuas ntxiv tau lees paub tias nws cov kev ua haujlwm nootropic yog qhov zoo tshaj plaws ntawm cov racetams, nrog potency30-60 npaug siab dua piracetam. Nws kuj tau raug txheeb xyuas tias yog tus neeg sib tw rau lub hlwb kev ua haujlwm dluab tracers, ua rau nws ib tug dual-function compound nrog tus nqi nyob rau hauv ob qho tib si nootropic therapy thiab neuroimaging kev tshawb fawb. Cov kev tshawb pom no tau txhawb nqa kev siv dav dav ntawm hydrazide-muaj moieties hauv kev tsim cov tshuaj hauv nruab nrab paj hlwb.
FAQ
Dab tsi yog cov yam ntxwv tseem ceeb ua tau zoo piv nrog cov racetams?
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Sib txawv ntawm cov khoom siv racetam zoo tib yam nrog ib txoj hauv kev tswj hwm, nws qhov tshwj xeeb hydrazide kev hloov kho cov qauv ua rau nws muaj cov ntshav muaj zog dua - lub hlwb thaiv kev nkag mus rau lub hlwb thiab lub sijhawm ua haujlwm ntev dua. Nws tsis tsuas yog txhim kho lub hlwb pos huab txhua hnub thiab lub hlwb qaug zog, tab sis kuj kho me ntsis kev txawj ntse los ntawm neural oxidative puas. Nws muaj qhov sib npaug ntawm kev tswj hwm ntau dua ntawm excitatory thiab inhibitory neurotransmitters, nrog qis excitotoxicity txaus ntshai thiab ua siab ntev rau ntev - siv nruab nrab.
Qhov pom zoo npaum li cas thiab kev siv?
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Rau kev txhim kho kev txawj ntse txhua hnub thiab kev ntxhov siab ntxhov siab, tus qauv pib koob tshuaj yog 10 mg ib hnub, uas tuaj yeem hloov kho raws li tus neeg mob lub cev. Txhawm rau kom tsis txhob muaj kev ua siab ntev ntawm neural, kev siv tsis tu ncua yog pom zoo nrog rau qhov tsim nyog tshem tawm. Nws yog soluble nyob rau hauv dej thiab methanol, thiab yuav ruaj khov yaj nyob rau hauv sterile saline rau kev sim thiab cov pa siv, nrog ruaj khov nqus thiab pib sai sai.
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