Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm pyrroloquinoline quinone disodium ntsev cas 122628-50-6 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo pyrroloquinoline quinone disodium ntsev cas 122628-50-6 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Pyrroloquinoline quinone disodium ntsev(PQQ-2Na) yog ib qho organic molecule uas muaj kev lom zem tshwj xeeb, nrog rau cov mis molecular C14H4N2Na2O8 thiab CAS 122628-50-6. Nws zoo nkaus li cov xim liab xim av nyob rau hauv chav tsev kub thiab siab thiab belongs rau cov dej-soluble B pawg vitamin tebchaw. Cov tshuaj no tau pib cais tawm ntawm kab lis kev cai ntawm cov kab mob methylotrophic thiab hu ua "fourteenth vitamin" hauv ntiaj teb kev kho mob zej zog vim nws lub cev muaj zog zoo ib yam li cov vitamins.
PQQ-2Na muaj dav nyob rau hauv prokaryotes, nroj tsuag, thiab tsiaj txhu, xws li fermented soybeans, ntsuab peppers, kiwifruit, parsley, tshuaj yej, papaya, spinach, celery, thiab mis nyuj. Nws yog ib qho khoom noj tseem ceeb rau cov tsiaj txhu thiab ua lub luag haujlwm tseem ceeb hauv kev tswj kev tiv thaiv kab mob. Raws li ib tug tshiab cofactor, PQQ-2Na plays lub luag hauj lwm nyob rau hauv kev hloov electrons, protons, thiab chemical pawg nyob rau hauv enzymatic cov tshuaj tiv thaiv, thaum tseem stimulating microbial kev loj hlob, nroj tsuag paj ntoos germination, thiab cog kev loj hlob.
Nws cov haujlwm tseem ceeb hauv kev ua liaj ua teb muaj xws li antioxidant thiab dawb radical scavenging peev xwm deb tshaj vitamin C, uas tuaj yeem txo oxidative kev nyuaj siab puas tsuaj; Txhawb txoj kev loj hlob ntawm mitochondrial los ntawm kev ua kom cov xov tooj ntawm tes taw qhia txoj hauv kev kom nce mitochondrial suav thiab txhim kho lub zog metabolism; Kev tswj hwm kev tiv thaiv kab mob, txhim kho kev tiv thaiv kab mob ntawm tes, thiab txhim kho kev tsim cov tshuaj tiv thaiv kab mob; Neuroprotection, induction ntawm paj hlwb kev loj hlob zoo synthesis, txhawb cov paj hlwb regeneration, muaj peev xwm tiv thaiv thiab kho cov teebmeem ntawm neurological kab mob xws li Parkinson tus kab mob.
PQQ-2Na tau lees paub los ntawm cov koom haum tswj hwm loj thoob ntiaj teb thiab tau pom zoo ua cov khoom noj tshiab rau kev siv dej haus, tshuaj noj, thiab lwm yam. Vim nws ntau lub hom phiaj thiab ntau qhov kev ua haujlwm lom neeg lom neeg, nws tau qhia dav dav hauv daim ntawv thov kev cia siab hauv kev ua haujlwm ntawm zaub mov, tshuaj, thiab kev ua liaj ua teb.
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Tshuaj Formula |
C22H17N3Na2O4 |
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Exact Mass |
433 |
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Molecular Luj |
433 |
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m/z |
433 (100.0%), 434 (23.8%), 435 (2.7%), 434 (1.1%) |
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Elemental Analysis |
C, 60,97; H, 3,95; N, 9,70; Na, 10,61; 14.77 Nws |
Pyrroloquinoline quinone disodium ntsev(PQQ-2Na) yog ib qho organic molecule uas muaj kev lom zem tshwj xeeb. Txij li thaum nws nrhiav tau nyob rau hauv 1979, nws tau nyiam tsis tu ncua ntawm cov khoom noj khoom haus, kws tshuaj, thiab cov khoom noj uas muaj txiaj ntsig zoo vim nws txoj haujlwm dav dav thiab muaj peev xwm siv tau. Raws li cov tshuaj cofactor tshiab, PQQ muaj cov vitamin zoo li cov khoom thiab muaj dav nyob rau hauv prokaryotes, nroj tsuag, thiab tsiaj txhu, tshwj xeeb tshaj yog nyob rau hauv cov zaub mov fermented, ntsuab nplooj zaub, txiv hmab txiv ntoo, thiab mis nyuj haus.
1. Mitochondrial biogenesis thiab cellular zog li
PQQ nce tus naj npawb ntawm mitochondria thiab ua kom zoo dua lawv txoj haujlwm los ntawm kev ua kom muaj cov teeb meem tseem ceeb hauv kev koom tes hauv intracellular mitochondrial biogenesis, xws li PGC-1 . Kev tshawb fawb tau pom tias kev noj txhua hnub ntawm 20mg PQQ tuaj yeem ua kom cov mitochondrial ntom ntom ntawm tib neeg fibroblasts los ntawm ntau dua 30TP. Cov nyhuv no yog qhov tseem ceeb hauv kev ua kis las khoom noj khoom haus, piv txwv li, thaum ua ke nrog coenzyme Q10, qib ntawm coenzyme Q10 hauv mitochondria tuaj yeem ua ob npaug, ua kom cov leeg qaug zog tom qab qoj ib ce.
2. Kev cuam tshuam cov kab mob metabolic
Rau cov neeg mob metabolic syndrome, PQQ txhim kho mitochondrial fatty acid oxidation muaj peev xwm thiab txo cov roj cholesterol thiab triglyceride ntau ntau. Cov kev sim tshuaj ntsuam xyuas tau pom tias ntxiv PQQ (20mg / hnub) rau 12 lub lis piam sib law liag tuaj yeem txo cov ntshav qabzib sai ntawm 12% thiab nce insulin rhiab heev ntawm 18% hauv cov neeg mob. Cov txheej txheem yuav cuam tshuam nrog PQQ ua kom txoj hauv kev AMPK thiab inhibiting kev qhia ntawm cov noob muaj feem xyuam rau cov roj synthesis.
1. Kev tiv thaiv thiab kho cov kab mob neurodegenerative
PQQ muaj peev xwm cuam tshuam rau Alzheimer's disease thiab Parkinson's disease. Cov kev sim tsiaj tau pom tias PQQ tuaj yeem cuam tshuam - amyloid protein aggregation, txo cov neuronal apoptosis, thiab txhawb kev tsim kho synaptic los ntawm kev txhawb nqa BDNF (hlwb- tau txais cov txiaj ntsig neurotrophic)). Txoj kev tshawb fawb txog kev paub txog kev ua haujlwm hauv cov neeg laus hauv Nyij Pooj tau pom tias tom qab ntxiv nrog 20mg PQQ txhua hnub rau 12 lub lis piam, cov neeg koom nrog cov qhab nia xeem tau nce 23% thiab cov ntshav hauv hlwb nce 15%.
2. Kev txhim kho ntawm kev pw tsaug zog zoo
PQQ alleviates ntxhov siab vim hais txog insomnia los ntawm kev tswj cov hypothalamic pituitary adrenal axis (HPA axis) thiab txo cov qib cortisol (qhov nruab nrab qis ntawm 28%). Thaum ua ke nrog GABA, lub sij hawm kom tsaug zog yog txo los ntawm 40% thiab lub sij hawm ntawm kev pw tsaug zog yog nce los ntawm 35%. Qhov kev sib koom ua ke no yog qhov tseem ceeb hauv kev ua haujlwm siab - xws li cov kws tsav dav hlau, thiab tuaj yeem txhim kho kev ceeb toom ntawm kev ua haujlwm hnub tom ntej.
1. Dawb radical scavenging thiab oxidative stress inhibition
Lub peev xwm antioxidant ntawmpyrroloquinoline quinone disodium ntsevyog 5000 npaug ntawm cov vitamin C, thiab nws muaj peev xwm ua hauj lwm los ntawm ib tug dual mechanism: ncaj qha neutralizing reactive oxygen hom (ROS) xws li superoxide anions thiab hydroxyl radicals; Ua kom txoj hauv kev Nrf2 thiab txhawb kev qhia ntawm endogenous antioxidant enzymes xws li SOD thiab GSH Px. Hauv cov qauv kev raug mob ntawm lub siab cawv, PQQ tuaj yeem txo MDA (malondialdehyde) cov ntsiab lus hauv daim siab cov ntaub so ntswg los ntawm 62% thiab nce GSH qib los ntawm 45%.
2. Lub cev tiv thaiv cov nyhuv
Lub siab: PQQ txo qis cov ntshav ALT thiab AST hauv cov nas uas muaj cawv ua rau lub siab raug mob los ntawm inhibiting NF - κ B txoj hauv kev, txo qhov tso tawm ntawm cov kab mob xws li TNF - thiab IL-6.
Cov hlab plawv: PQQ tuaj yeem cuam tshuam oxidative hloov ntawm LDL thiab txo qhov tsim ntawm atherosclerotic plaque. Cov kev tshawb fawb soj ntsuam tau pom tias tom qab 6 lub hlis ntawm kev ntxiv PQQ hauv cov neeg mob uas muaj kab mob plawv, qhov intima-media thickness (IMT) ntawm cov hlab ntsha carotid txo qis los ntawm 0.12mm.
Raum: Hauv cov qauv ntawm ntshav qab zib nephropathy, PQQ txo glomerular cell apoptosis thiab tso zis protein ntau npaum li 53% los ntawm kev ua kom PI3K / Akt txoj hauv kev.
1. Ua kom lub cev tiv thaiv kab mob
PQQ tuaj yeem txhim kho NK cell kev ua haujlwm (los ntawm 32%), txhawb B cell sib txawv rau hauv cov ntshav plasma, thiab nce cov tshuaj tiv thaiv kab mob los ntawm 2.1 npaug. Hauv cov neeg laus, PQQ ntxiv tuaj yeem ua rau cov tshuaj tiv thaiv kab mob khaub thuas nce ntxiv los ntawm 40% thiab txo tus kab mob los ntawm 35%.
2. Antitumor mechanism
PQQ siv tshuaj tiv thaiv- mob qog noj ntshav los ntawm ntau txoj hauv kev:
Kev tua ncaj qha: induces mitochondrial membrane muaj peev xwm vau nyob rau hauv cov qog hlwb, ua rau caspase-3 nyob ntawm apoptosis txoj kev.
Metabolic inhibition: Thaiv cov piam thaj hauv cov qog hlwb thiab inhibiting cov nyhuv Warburg.
Angiogenesis inhibition: Downregulation ntawm VEGF qhia txo cov qog angiogenesis.
Nyob rau hauv cov qauv qog nqaij hlav qog nqaij hlav cancer mis, PQQ ua ke nrog cov tshuaj khomob tuaj yeem txo cov qog ntim los ntawm 68%, uas yog qhov zoo dua li ib pawg tshuaj kho mob.
1. Cov khoom siv kho mob hlwb
Lub hlwb boosting ntxiv formulated nrog PQQ, PS (phosphatidylserine), thiab extract ntawm Portulaca oleracea tuaj yeem ua rau kom muaj peev xwm ua haujlwm nco (los ntawm 27%) thiab lub sijhawm mloog (los ntawm 34%). Cov khoom lag luam no muaj kev sib koom ua lag luam ntawm 18% hauv Nyiv.
2. Anti laus ua ke
Lub qhov ncauj kev zoo nkauj capsule ua ke nrog PQQ thiab NMN (nicotinamide mononucleotide) activates SIRT1 ntev lub neej, ua rau daim tawv nqaij collagen synthesis los ntawm 41% thiab txo qhov tob ntawm wrinkles los ntawm 29%.
Cov kev kuaj mob tau pom tias tom qab 8 lub lis piam ntawm kev siv tas li, daim tawv nqaij elasticity Performance index ntawm cov ntsiab lus tau nce 38%.
3. Khoom noj khoom haus kev ua kis las
PQQ Coenzyme Q10 complex tsim rau cov neeg ncaws pob tuaj yeem nce siab tshaj plaws oxygen uptake (VO2max) los ntawm 12% thiab ncua qhov pib ntawm kev tawm dag zog- ua rau qaug zog los ntawm 23%. Tom qab daim ntawv thov hauv triathletes, lub sijhawm ua tiav qhov nruab nrab raug txo los ntawm 7.2 feeb.
1. Daim tawv nqaij tiv thaiv -aging
Pyrroloquinoline quinone disodium ntsevtxhawb hom I collagen synthesis los ntawm activating TGF - /Smad txoj hauv kev fibroblasts. Essence muaj 0.1% PQQ tuaj yeem ua kom tawv nqaij khov kho los ntawm 31% thiab txo cov pigmentation los ntawm 42%.
2. Kev txhawb nqa tsiaj txhu
Raws li kev pub mis ntxiv, PQQ tuaj yeem ua rau cov leeg nqaij feem pua ntawm cov nqaij qaib broiler nce 8% thiab txo qhov pub rau nqaij piv los ntawm 0.15; Tom qab ntxiv nws rau sow pub, tus naj npawb ntawm piglets yug tau nce los ntawm 1.2 rau ib lub litter, thiab qhov hnyav ntawm piglets tau nce los ntawm 0.8 kg.
Kev txhim kho keeb kwm ntawm pyrroloquinoline quinone sodium ntsev
Kev tshawb pom ntawm pyrroloquinoline quinone sodium ntsev (PQQ) yog los ntawm cov kws tshawb fawb hauv - kev tshawb fawb tob ntawm microbial metabolic mechanisms. Nyob rau xyoo 1950, Norwegian chemist JG Hauge tau tshawb pom ib qho enzyme tshwj xeeb hauv Pseudomonas fluorescens kab lis kev cai uas txhawb nqa cov metabolism thaum kawm. Txawm li cas los xij, txwv los ntawm cov txheej txheem thev naus laus zis thaum lub sijhawm, nws tsis tuaj yeem txiav txim siab cov tshuaj muaj pes tsawg leeg ntawm enzyme. Qhov kev sib tw no tsis tau daws kom txog rau thaum xyoo 1979 thaum Japanese chemist Ryu Sakamoto tau siv txoj kev rho tawm tshiab los cais PQQ los ntawm cov kua qaub dub (cov khoom noj fermented) hauv Amami Oshima, Nyiv, thiab lees paub nws cov qauv molecular thawj zaug siv X-ray crystal diffraction technology. Qhov kev tshawb pom no qhia tau tias PQQ yog tricarboxylic acid quinone compound uas yog oxidoreductase cofactor tsev neeg, tso lub hauv paus rau kev tshawb fawb tom ntej.
Nyob rau xyoo 1980, Ryuo Sakamoto pab pawg tau tshawb pom los ntawm ntau qhov kev sim uas PQQ tuaj yeem tsis tsuas yog koom nrog cov tshuaj tiv thaiv redox raws li ib qho enzyme cofactor, tab sis kuj txhawb kev loj hlob ntawm microbial thiab metabolism, thiab tseem txhawb nqa cellular zog. Qhov kev tshawb pom no tau nyiam thoob plaws ntiaj teb los ntawm cov zej zog kev tshawb fawb. Xyoo 1989, PQQ tau lees paub tias yog ib qho tseem ceeb ntawm cov khoom muaj sia nyob, cim nws txoj kev hloov ntawm cov enzyme cofactor yooj yim mus rau cov khoom noj muaj txiaj ntsig. Hauv xyoo 2003, cov kws tshawb fawb Nyij Pooj tau lees paub los ntawm kev sim cov nas uas tsis muaj PQQ yuav nthuav tawm cov xwm txheej xws li kev muaj peev xwm ua me nyuam thiab kev tiv thaiv tsis zoo, thiab xav tias nws yuav muaj txiaj ntsig zoo sib xws rau tib neeg. Raws li qhov no, PQQ tau raug cais raws li "14th vitamin" thiab tau dhau los ua ib tus tswv cuab tshiab ntawm cov dej- cov vitamin B soluble. Qhov kev lees paub no tsis yog tsuas yog txhim kho kev tshawb fawb ntawm PQQ, tab sis kuj tseem muab lub hauv paus theoretical rau nws daim ntawv thov hauv cov khoom noj khoom haus thiab tshuaj.
Nrog rau kev tshwm sim maj mam ntawm PQQ cov kev ua haujlwm lom neeg, nws txoj kev nyab xeeb thiab muaj peev xwm siv tau raug lees paub los ntawm cov koom haum tswj hwm thoob ntiaj teb. Xyoo 2012, Kev Noj Qab Haus Huv Canada pom zoo PQQ ua zaub mov noj qab haus huv; Hauv xyoo 2016, US FDA tau tso cai rau nws GRAS (Feem ntau Pom tau tias muaj kev nyab xeeb), tso cai rau nws siv rau hauv cov khoom noj xws li dej qab zib; Nyiv muab faib ua cov khoom noj uas tsis yog tshuaj; EU pom zoo nws raws li kev noj haus ntxiv lossis zaub mov noj qab haus huv. Xyoo 2022, Tuam Tshoj National Health Commission tau pom zoo PQQ ua cov khoom noj tshiab, kos npe rau nws txoj kev nkag mus rau hauv Suav lag luam. Tib lub sijhawm, PQQ cov thev naus laus zis ntau lawm kuj tau ua tiav. Cov txheej txheem tshuaj synthesis dominates vim nws yooj yim muaj cov khoom siv raw thiab tus nqi qis, tab sis nws kuj ntsib teeb meem ib puag ncig; Txawm hais tias microbial fermentation yog ib puag ncig tus phooj ywg thiab nyab xeeb, nws ntsib cov teeb meem xws li nyuaj rau kev tau txais cov kab mob thiab cov nqi sib cais siab. Kev sib txuas ntawm ob lub thev naus laus zis tau txhawb nqa cov txheej txheem kev lag luam ntawm PQQ.
Nyob rau hauv xyoo tas los no, daim ntawv thov Scope ntawmpyrroloquinoline quinone disodium ntsevtau nthuav dav los ntawm cov khoom noj khoom haus thawj zaug rau ntau yam xws li tshuaj, tshuaj pleev ib ce, thiab pub. Hauv kev kho mob, nws cov tshuaj tiv thaiv kab mob antioxidant, neuroprotective thiab metabolic tswj kev ua haujlwm yog siv los tsim cov khoom siv kho mob rau ntshav siab, kab mob plawv, kab mob neurodegenerative thiab ntshav qab zib; Hauv kev lag luam tshuaj pleev ib ce, PQQ's anti-cov khoom qub ua rau nws muaj cov khoom tseem ceeb hauv qhov ncauj kev zoo nkauj thiab cov khoom tu tawv nqaij; Hauv kev ua liaj ua teb, cov chiv cog qoob loo uas muaj PQQ tuaj yeem ua rau cov qoob loo nce ntxiv, thaum ua cov khoom noj ntxiv, lawv tuaj yeem txhim kho tsiaj antioxidant muaj peev xwm thiab txhim kho kev yug me nyuam. Tsis tas li ntawd, kev sib xyaw ntawm PQQ nrog coenzyme Q10, NMN thiab lwm yam tshuaj ntxiv ua kom nws cov txiaj ntsig kev noj qab haus huv, ua tau raws li cov neeg siv khoom xav tau cov khoom noj muaj txiaj ntsig zoo.
Cov lus nug nquag
Cov txiaj ntsig ntawm PQQ disodium ntsev yog dab tsi?
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PQQ (pyrroloquinoline quinone) disodium ntsev yog ib qho bioavailable compound uas ua rau muaj zog antioxidant thiab cellular energizer. Nws yog feem ntau lees paub rau kev txhawb nqa kev loj hlob ntawm mitochondria tshiab, txhawb kev paub txog kev ua haujlwm, txhim kho cov hlab plawv kev noj qab haus huv, thiab txo qhov mob thiab cov leeg nqaij.
Puas yog PQQ nyuaj rau lub siab?
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Raws li lub zog antioxidant, PQQ tuaj yeem ua kom muaj zog los tiv thaiv kev poob ntawm cov cell secretory hauv daim siab los ntawm BKO-induced oxidative stress (45). Hauv txoj kev tshawb fawb tam sim no, kev paub txog PQQ tau txuas ntxiv, thiab kev kho mob nrog PQQ- noj zaub mov ntxiv tau pom tias muaj kev tiv thaiv zoo rau lub siab.
PQQ puas muaj kev nyab xeeb rau lub raum?
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Tiv thaiv raum puas tsuaj
Cov kws tshawb fawb niaj hnub tshawb nrhiav txoj hauv kev los tiv thaiv lub raum ua haujlwm thiab tsis txhob ua rau lub raum tsis ua haujlwm. Cov txiaj ntsig ntawm kev tshawb fawb hauv cov qauv tsiaj qhia tias kev siv PQQ pab tiv thaiv ob lub raum, txawm tias nyob rau hauv lub ntsej muag ntawm ntshav qab zib thiab nce ntshav qabzib.
Cim npe nrov: pyrroloquinoline quinone disodium ntsev cas 122628-50-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom