Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam thiab cov khoom lag luam articaine part cas 23964-58-1 hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo articaine hmoov hmoov cuabataine hmoov li 23964-58-1 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Articaine HmoovPuas yog ib qho ester raws cov tshuaj loog hauv zos ua kom loog nrog lub ntsej muag dawb crystalline hmoov. Nws cov fydrochloride yog soluble hauv dej (ntau dua lossis sib npaug zos rau 5mg / ml) thiab dimethyl sulfoxide (DMSOY). Nws cov hmoov daim foos yog khaws cia ntawm 2 {- 8℃rau 2 xyoos thiab {20 20℃rau 3 xyoos; Daim ntawv hnyav tuaj yeem khaws cia ntawm -}} 20℃rau 6 lub hlis thiab -80℃rau 1 xyoo. Articaine exerts hauv zos kev cuam tshuam los ntawm kev thim rov qab mus rau alpha subbage-gated sodium remnels hauv kev sib kis ntawm cov hlab ntshav ntawm cov hlab ntsha impulses. Nws yog tsuas yog siv rau cov hniav tawm, pulp kev kho mob, thiab qhov ncauj kho mob xws li qhov ncauj phais kab mob rau sab saud thiab qis dua cov hniav. Nws tseem siv tau ua ke nrog adrenaline (1: 100000 lossis 1: 200000) txhawm rau txhim kho kev ua kom ntshav thiab txo kom ntshav los ntshav. Nws kuj tseem siv tau los ua cov tshuaj tsim los kawm cov nuj nqi thiab kev kho mob tshuab ntawm voltage-gated sodium raws. Tshawb nws lub luag haujlwm tiv thaiv hauv cov qauv ntawm kev ua haujlwm mob raum, xws li los ntawm inhibiting bhibiting bhibiting NF - κ B ua kom thiab NLR3 inflammasome everyway.
|
|
|
|
Tshuaj Cov Qauv |
C13H20N2O3S |
|
Muaj pes tsawg leej |
284.12 |
|
Molecular hnyav |
284.37 |
|
m/z |
284.12 (100.0%), 285.12 (14.1%), 286.12 (4.5%) |
|
Kev Ntsuam Xyuas |
C, 54.91; H, 7.09; N, 9.85; O, 16.88; S, 11.27 |
Cov tub ntxhais siv ntawmArticaine Hmoovyog ua tshuaj loog hauv zos, siv dav hauv kev phais, thiab qee qhov kev phais mob me. Nws thim rov qab cov hluav taws xob voltage - Kuv yog cov hlab ntsha mem tes, inhibits qhov kev sib kis ntawm cov hlab ntsha impulses, thiab yog li ua kom muaj kev tshuaj loog hauv cheeb tsam.
Hauv kev kho hniav kev kho hniav, Atecamin tau dhau los ua cov tshuaj loog uas nyiam nyiam vim nws lub chaw muag tshuaj tshwj xeeb:
Kev nrawm: Cov tshuaj loog tuaj yeem tsim nyob hauv 1-3 feeb tom qab txhaj tshuaj, txo qis tus neeg mob tos sijhawm. Piv txwv li, hauv cov kab mob posterior paxterior me ntsis kev phais, tom qab lub sijhawm ua kom ntshav tau tuaj yeem ncav sijhawm ntau dua li cov tshuaj loog loog hauv cheeb tsam.
Cov tshuaj loog muaj txiaj ntsig zoo: nws cov nyhuv tshuaj loog yog 1.5-2 lub sij hawm uas ntawm lidocaine, tshwj xeeb tshaj yog haum cov hniav kev tshem tawm thiab kev kho cov dej hiav txwv. Cov ntaub ntawv kuaj mob qhia tau tias kev ua tiav ntawm kev ua tiav ntawm hluav taws xob kev kuaj yog 64.5%, siab dua lwm cov tshuaj loog hauv cheeb tsam.
Precise kev ua haujlwm ntawm kev nqis tes ua: los ntawm kev xa cov tshuaj loog thiab txhaws ntswg ntawm cov tshuaj loog uas sib sib zog nqus thiab txo qis kev pheej hmoo ntawm cov kev pheej hmoo ntawm lub cev tsis zoo. Piv txwv li, thaum lub ntsiab lus maxillary Sination kev phais, cov yeeb yam hauv zos tuaj yeem ncav cuag 100 zaug uas ntawm cov tshuaj loog uas muaj txiaj ntsig txaus hauv qhov chaw phais mob.
Tsawg ntawm kev ua xua kev pheej hmoo tsawg: Ua kev ua haujlwm tsis haum hauv zos, qhov tshwm sim ntawm kev ua xua tsis haum rau cov neeg mob hauv zos (ua rau cov neeg mob tsis haum.
Kev Tshuaj Ntsuam Xyuas Kev Tshuaj loog rau kev phais luv luv
Ntxiv rau kev kho hniav, articaine tseem tuaj yeem siv rau cov phais luv luv:
Daim tawv nqaij Biopsy: Siv Infiltration Anesthes Kev Ua Yeeb Yam Hauv Nroog txhawm rau txo tus mob mob thiab txhim kho kev ua haujlwm biopsy.
Cov Tum Oppic Revolution: Xws li Lipoma thiab Fibroid resection, nws luv {{{{{}}}}}}}}}} 10 feeb).
Kev phais micro micro, xws li phais nqaij muag muag thiab txhaj tshuaj kom hniav zoo nkauj thiab cov ntaub so ntswg muaj zog thiab tuaj yeem ua kom pom tseeb qhov chaw phais.
Pharmacological Automchanism: Sodium channel blockade thiab ntau txoj kev thaiv
Cov nyhuv tshuaj loog ntawmArticaine HmoovStems los ntawm nws cov cai meej ntawm cov hlab ntaws:
Sodium Channel Thaiv
Cov pab pawg uas muaj ntxhiab thiab cov pab pawg lipophilic hauv cov molecule ntawm articaine ua rau nws yooj yim rau kev nkag mus rau lub suab paj nruag alpha Cov txheej txheem no zoo ib yam li Lidocaine, tab sis tus thawj coj nplhaib ntawm articaine txhim kho kev txhim kho rau sodium raws, ua rau muaj kev ua tau sai dua thiab muaj txiaj ntsig zoo dua.
Anti Inflammatory thiab Cov Nyiaj Tiv Thaiv Kev Tiv Thaiv Tsis Tau (Tsis Tshuaj Txhuam)
Nyob rau hauv xyoo tas los, kev tshawb fawb tau pom tias Atecamin tuaj yeem txo cov Lipopolysacysacysaccharide (lps) Hauv cov kev sim tsiaj, pretreatment nrog articaine tuaj yeem txo qis cov cim ntawm lub raum (xws li cov cuav creatinine thiab urea nitrogen) thiab txo qis ntawm tes inflamtration. Cov nyhuv no yuav cuam tshuam nrog nws cov qauv ester, tab sis nws tseem tsis tau thov hauv chaw kuaj mob anti {{vim kev kho mob.
Cov Ntawv Thov Kev Kho Mob thiab Cov Qauv Zoo
Cov ntawv thov raug nyob hauv kev phais hniav
Cov tshuaj txhuam hniav ntxiv: kev rho tawm ntawm Maxillary cov hniav liab qab tuaj yeem ua tiav los ntawm buccal subsehesia, zam kev puas tsuaj uas yuav tshwm sim nrog kev ua kom loog.
Hauv paus canal kho: lub potent anteeshesia ntawm articaine ua kom cov neeg mob tsis muaj kev mob tag nrho, tshwj xeeb yog cov pulp necrosis lossis mob pungtis.
Nquag Priccelionain Kev Rov Qab Los: Thaum lub sijhawm npaj theem, tuaj yeem npaj tau txog 40 feeb ntawm lub sijhawm ua kom loog kom tau raws li kev siv tshuaj kho mob.
Ua ke nrog adrenaline
Articaine feem ntau siv hauv kev sib xyaw nrog adrenaline (1: 100000 lossis 1: 200000) rau lub sijhawm ua kom ntev ntev thiab txo qis:
Txuas ntxiv rau kev nqis tes ua: adrenaline constricts cov hlab ntshav, qeeb zuj zus kev nqus ntawm Articaine thiab nthuav nws lub loog thaum 20-90 feeb.
Txo cov kev nqus kom tsawg: qis rau cov tshuaj tiv thaiv ntshav tshuaj, txo qhov kev pheej hmoo ntawm kev cuam tshuam zoo xws li kiv taub hau thiab palpitations. Piv txwv li, tom qab ntxiv adrenaline ntxiv rau 4% Arrenalaine, Qhov tshwm sim ntawm Lip Paus rau cov neeg mob txo ntawm 98%, thiab tsis muaj lus ceeb toom txog kev tsis zoo.
Cov tshuaj rau cov neeg tshwj xeeb
Cov neeg mob pediatric: kev nyab xeeb ntawm articaine hauv cov menyuam tau raug siv tau. Kev kawm txog cov menyuam hnub nyoog 4-13 pom tias VAS qhab nia (xws li kev phais hniav ntxiv) yog 0.1, ob leeg qis dua cov pab pawg Lidocaine.
Cov neeg laus cov neeg mob: cov metabolites ntawm Articaine (xws li Articaine acid) yog feem ntau tau ua tiav los ntawm ob lub raum. Txo lub raum muaj nuj nqi nyob rau hauv cov neeg laus zog yuav ntev nws ib nrab {1} Lub neej, tab sis cov kev tshawb nrhiav kev sib tw tsis pom kev cuam tshuam thiab nws tseem tuaj yeem siv tau.
Kev Siv thiab Kev Ceev Faj
Koob tshuaj thiab concentration xaiv
Cov koob tshuaj uas muaj rau cov neeg laus
Ib qho kev txhaj tshuaj ib zaug yuav tsum tsis pub tshaj 7mg / kg (suav ua articaine), thiab qhov siab tshaj plaws pom zoo siv ntawm 4% (muaj 1: 100000mg (13,9mL).
Menyuam yaus noj
Kho raws li lub cev hnyav, feem ntau 2-4mg / kg, nrog qhov siab tshaj plaws ib koob tsis tshaj 3mg / kg.
Cov kev xaiv siab
4% articaine (muaj adrenaline) yog haum rau kev phais hniav feem ntau; 2% Articaine (tsis suav adrenaline) yog siv rau cov neeg mob uas muaj mob kub siab lossis mob plawv.
Cov ntsiab lus tseem ceeb ntawm kev txhaj tshuaj tshuab
Immersion Tshuaj Pleev
Siv "kiv cua {- Daim puab txoj kev txhaj tshuaj", rab koob yog ntxig rau hauv cov koob txhaj tshuaj kom ntseeg tau tias muaj kev tshuaj loog.
Thaiv Tshuaj loog
Yog tias kev ua kom loog rau qhov qis dua alveolar hlab ntsha, muab qhov tseeb ntawm Mandibular Inamen yog qhov tsim nyog kom tsis txhob ua kom muaj kev puas tsuaj ntawm nurovascular pob.
Txhaj tshuaj tiv thaiv ceev
Maj mam txhaj (txog 1ml ib feeb) los txo tus mob mob thiab nqaij puas tsuaj.
Cov kev tsis zoo thiab cov teeb meem
Cov Kev Ruaj Ntseg
Cov tshuaj tiv thaiv hauv zos: Qhov mob ntawm qhov chaw txhaj tshuaj (qhov xwm txheej ntawm kwv yees li 10%), o (2%), hematoma (1%).
Cov Txheej Txheem: Kiv (3%), tinnitations (1%), feem ntau hloov chaw (tuaj yeem hloov pauv tom qab so.
Cov tshuaj tiv thaiv loj heev
Kev ua xua: Muaj qhov tshwm sim tsawg dua 0.1%, ua pa tawm ua pa, ua pa nyuaj, thiab txawm tias muaj kev cawmdim nyuaj, xav tau kev cawm dim.
Kev raug mob neurological: Ntev ntev loog lossis zoo li tus nqi txawv txawv (nrog rau qhov muaj feem ntawm 0.01%), feem ntau cuam tshuam nrog kev txhaj tshuaj txhaj.
qho piav
Cov tib neeg ua xua rau kev ua kom loog hauv cheeb tsam xws li articaine lossis kev tawm tsam.
Cov neeg mob uas mob siab loj thiab raum tsis sib xws (vim ua tau kev sib txuam ntawm cov metabolites).
Uncontrolled bypertension lossis arrhythmia cov neeg mob (adrenaline tej zaum yuav ua rau muaj mob).
Kev sib piv nrog lwm cov tshuaj loog hauv zos
Piv nrog Lidocaine
| Yam zoo | Articaine | Lidocaine |
| Hnub pib | 1-3 feeb | 3-5 feeb |
| Tshuaj loog ua tau zoo | Muaj zog (1.5-2 lub sij hawm muaj zog dua liidocaine) | Tswj kav |
| Ntev ntawm kev txiav txim | 20-40 feeb (tsis suav adrenaline) | 30-60 feeb (tsis suav adrenaline) |
| Kev tsis haum | Tsawg (chav kawm nkaum) | Ntau dua (cov khoom siv ntxiv rau kev ua xua) |
| Muaj feem | Cov menyuam yaus, cov laus, thiab cov neeg uas ua xua | Cov laus neeg laus |
Sib piv nrog Mexico
- Cov Koom Haum Kev Koom Tes: The Thiobenzene nplhaib tsim qauv ntawm articaine ua rau nws yooj yim rau kev nkag pob txha pob txha, ua rau nws lub cev loog ntawm cov hniav ntawv loj me; Mexicaine muaj lipid solubility thiab yuav tsum tau txhaj tshuaj ntau dua kom ua tiav cov nyhuv tib yam.
- Cov kev ntsuas metabolic:Articaine HmoovFeem ntau yog metabolized los ntawm daim siab, thaum meprrazole tau tawm los ntawm ob lub raum. Cov neeg mob uas muaj lub raum tsis zoo yuav xaiv cov articaine.
Cim npe nrov: Articaine Hmoov Li 23964-58-1, Tus neeg muab khoom, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, rau muag