4-Chlorobutyryl chlorideyog cov kua uas tsis muaj xim rau daj ntseg daj nrog cov khoom muaj zog irritating. Nws cov mis molecular yog C₄H₆Cl₂O thiab nws yog ib qho tseem ceeb organic hluavtaws intermediate. Cov yam ntxwv tseem ceeb tshaj plaws ntawm cov khoom sib xyaw no yog nyob rau hauv qhov tseeb tias nws cov molecule ib txhij muaj cov pab pawg acyl chloride uas muaj zog heev (-COCl) thiab cov tshuaj chlorine atom kawg ntawm cov saw hlau. Qhov no ob lub- pab pawg ua haujlwm tsim ua rau nws muaj txiaj ntsig zoo hauv cov tshuaj tiv thaiv. Cov pab pawg acyl chloride tau nkag mus rau acylation cov tshuaj tiv thaiv nrog ntau yam nucleophilic reagents (xws li cawv, amines), ua haujlwm zoo ntawm amide lossis ester bonds; thaum lub sij hawm chlorine atom kawg tuaj yeem ua rau intramolecular cyclization nyob rau hauv alkaline tej yam kev mob los tsim ib tug plaub -membered nplhaib lactone ( -butyrolactone), los yog undergo hloov cov tshuaj tiv thaiv nrog lwm cov nucleophilic reagents mus cuag cov carbon saw. Yog li ntawd, nws yog dav siv nyob rau hauv tshuaj chemistry (xws li nyob rau hauv cov synthesis ntawm tej yam psychotropic tshuaj thiab cov hlab plawv), tshuaj tua kab, thiab kev npaj ntawm monomers rau siab - cov ntaub ntawv molecular. Vim nws qhov hnyav hydrolysis thaum raug dej lossis dej noo thiab tso tawm cov roj corrosive hydrogen chloride, kev ua haujlwm yuav tsum tau ua raws li cov dej tsis muaj zog thiab muaj qhov cua txaus, thiab muaj cov cai tshwj xeeb rau kev khaws cia thiab kev thauj mus los.
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Tshuaj Formula |
C4H6Cl2O |
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Exact Mass |
140 |
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Molecular Luj |
141 |
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m/z |
140 (100.0%), 142 (63.9%), 144 (10.2%), 141 (4.3%), 143 (2.8%) |
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Elemental Analysis |
C, 34,08; H, 4,29; 50,29; 50. O, 11.35 Nws |
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Ib txoj kev chemical synthesis ntawm4-chlorobutyryl chloride, tus cwj pwm nyob rau hauv hais tias txoj kev piav qhia yog: nyob rau hauv tsis muaj cov kuab tshuaj los yog organic hnyav, raws li qhia nyob rau hauv Formula (II) - Cov tshuaj chlorination ntawm butyrolactone thiab bis (trichloromethyl) carbonate yog nqa tawm nyob rau hauv qhov kev txiav txim ntawm ib tug organic amine catalyst ntawm ib tug kub ntawm 50 mus rau 180 degree. Tom qab cov tshuaj tiv thaiv tiav lawm, cov tshuaj tiv thaiv kua yog kho kom tau raws li qhia hauv Formula (I); Tus nqi ntawm cov catalyst ntxiv yog - Cov txheej txheem rau kev sib txuas cov khoom lag luam muab los ntawm qhov kev tsim khoom tam sim no muaj qhov zoo ntawm cov khoom siv raw khoom yooj yim, yooj yim thiab nyab xeeb, thiab tsim nyog rau kev tsim khoom lag luam.
Cov txheej txheem txheej txheem rau kev sib txuas thiab kev ua kom huv ntawm cov khoom, suav nrog cov kauj ruam hauv qab no: - Cov crude nws tau tsim los ntawm cov tshuaj tiv thaiv ntawm butyrolactone thiab sulfoxide chloride nyob rau hauv lub catalysis ntawm ib tug tov catalyst, thiab ces purified. Lub purity ntawm cov khoom tiav yog ntau dua los yog sib npaug rau 99%, purity ntawm impurities yog<0.30%, and the yield was ≥ 90%; The waste gas generated in the production of it is comprehensively utilized to produce 30% hydrochloric acid and sodium sulfite solution, and the tailings are used for the production of 4-chlorobutyrate; The invention has simple process, convenient operation, high yield, high product purity, almost no discharge of three wastes, and is environmentally friendly.
Txoj kev npaj yog muab cov butyrolactone, anhydrous zinc chloride, thiab sulfoxide chloride nyob rau hauv cov tshuaj tiv thaiv hwj, do ntawm 55℃rau 12 teev, thiab sau cov khoom los ntawm kev txo qis distillation. los ntawm - Butyrolactone yog tau los ntawm chlorination. noj - Butyrolactone thiab zinc chloride tau nplawm thiab ua kom sov, thiab ua haujlwm ntawm 55-60℃rau 1 teev. Maj mam ntxiv sulfoxide chloride ntawm 60℃thiab ua rau 2h. Tshav kub rau 80℃hauv 5-6 teev. Cia sawv ntsug ib hmos, distil cov kua dej ntshiab ntawm atmospheric siab, thiab tom qab ntawd rov ua dua ib zaug. Sau cov feem kom tau4-chlorobutyryl chloride.
Kev tiv thaiv ib puag ncig siab dua: Nrog kev txhim kho txuas ntxiv ntawm kev tiv thaiv ib puag ncig, kev xav tau rau kev nyab xeeb tshuaj thiab kev tiv thaiv ib puag ncig kuj tau nce siab dua. Yog li ntawd, txoj kev loj hlob yav tom ntej yuav yog los tsim cov tshuaj zoo ib puag ncig thiab kev nyab xeeb dua, uas tseem yuav cuam tshuam rau kev tsim khoom.
Los ntawm lub chaw soj nstuam xav paub txog kev lag luam ncej
Nyob rau hauv dav dav ntawm cov organic chemistry,4-Chlorobutyryl Chlorideib zaug yog ib tug txo hwj chim "me player" nyob rau hauv lub chav kuaj. Txawm li cas los xij, ua tsaug rau nws cov khoom siv tshwj xeeb thiab kev siv dav, nws maj mam dhau los ua ib qho tseem ceeb hauv cov teb xws li tshuaj, tshuaj tua kab, thiab cov ntaub ntawv polymer, ua tiav qhov kev hloov pauv zoo kawg nkaus los ntawm kev xav paub hauv chav kuaj mus rau kev lag luam ncej.
"Lub Chemical Reaction Catalyst nyob rau hauv Laboratory"
Hauv cov qauv molecular ntawm 4-chlorobutyldichloroformate, kev sib koom ua ke ntawm pawg acyl (-COCl) thiab cov tshuaj chlorine atom (-Cl) endows nws nrog kev ua haujlwm siab heev. Hauv chav kuaj, nws tau pib siv los ua acylation reagent thiab koom nrog hauv kev sib txuas ntawm cov organic molecules complex. Piv txwv li, nyob rau hauv cov tshuaj synthesis, nws muaj peev xwm hnov mob nrog amine thiab cawv compounds los tsim amide los yog ester bonds, muab cov fragments tseem ceeb rau lub molecular molecular cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob. Qhov no "modular" hluavtaws muaj peev xwm ua rau nws yog ib qho cuab yeej tseem ceeb hauv kev tshawb fawb thiab kev tsim tshuaj tshiab.
Cov txheej txheem synthesis kuj tau ua kom zoo dua los ntawm txoj hauv kev mus rau qhov yooj yim. Thaum ntxov, cov kws tshawb fawb tau npaj 4-chlorobutyryl chloride los ntawm cov tshuaj chlorination ntawm 1,4-dichloro-1,4-butenedioic acid nrog hydrogen chloride. Txawm li cas los xij, cov ntaub ntawv raw khoom nyuaj tau txais thiab cov kev mob tshwm sim tau nruj. Nrog rau kev txhim kho thev naus laus zis, txoj kev sib txuas ib-kauj ruam siv -butanone ua cov khoom siv raw, catalyzed los ntawm zinc chloride thiab chlorosulfone chlorination, maj mam dhau los ua lub ntsiab. Txoj kev no muaj cov ntaub ntawv yooj yim-rau-tau txais cov ntaub ntawv raw, kev ua haujlwm nyab xeeb, thiab kev nce ntxiv hauv cov tshuaj tiv thaiv tawm los, tso lub hauv paus rau kev tsim khoom ntawm 4-chlorobutyryl chloride.
"Lub Molecular Architect ntawm Pharmaceutical Industry"
Hauv kev lag luam tshuaj, lub luag haujlwm "tus kws tsim qauv" ntawm 4-chlorobutyldichloroformate yog qhov tshwj xeeb. Nws yog ib qho tseem ceeb nruab nrab rau synthesizing tshuaj tiv thaiv qog thiab tshuaj tua kab mob. Piv txwv li, nyob rau hauv txoj kev sib txuas ntawm haloperidol (ib qho tshuaj tiv thaiv kev puas siab puas ntsws), 4-chlorobutyldichloroformate tau dhau los ua cov tshuaj tiv thaiv acylation los qhia cov pab pawg ua haujlwm tshwj xeeb, muab cov chaw ua haujlwm rau kev hloov kho molecular tom ntej. Tsis tas li ntawd, nws kuj tuaj yeem siv los ua ke cov nruab nrab ntawm cov nroj tsuag kev loj hlob regulator antistatic, uas tswj qhov sib npaug ntawm cov tshuaj hormones cog los txhim kho cov qoob loo tiv thaiv qhov chaw nyob thiab indirectly kom ruaj ntseg zaub mov.
Nws siab reactivity thiab selectivity ua rau cov txheej txheem tshuaj synthesis ntau npaum thiab tswj tau. Cov kws tshawb fawb tuaj yeem ua tiav cov txiaj ntsig siab thiab siab purity ntawm cov khoom lag luam los ntawm kev tswj cov tshuaj tiv thaiv zoo (xws li kub, hnyav, thiab cov tshuaj catalyst), yog li txo cov nqi tsim khoom thiab ib puag ncig muaj kuab paug. Daim ntawv thov ntawm no "ntsuab chemistry" lub tswv yim tau txhawb nqa qhov nrov ntawm 4-chlorobutyryl chloride hauv kev lag luam kws tshuaj.
"Lub Cav Tshiab" ntawm cov tshuaj tua kab thiab cov khoom siv polymer
Hauv thaj tsam ntawm cov tshuaj tua kab, 4-chlorobutyryl chloride yog ib qho tseem ceeb raw khoom rau synthesizing herbicides thiab tshuaj tua kab. Nws tuaj yeem ua ke nrog cov tshuaj tsw qab amines thiab cov tshuaj heterocyclic los ntawm cov tshuaj tiv thaiv acylation los tsim cov molecules nrog kev ua haujlwm lom neeg. Piv txwv li, qee cov tshuaj tua kab mob tshiab txhim kho lawv lub hom phiaj thiab kev pheej hmoo los ntawm kev qhia txog 4-chlorobutyryl chloride pawg, thaum txo qhov cuam tshuam rau cov kab mob uas tsis yog hom phiaj. Qhov kev thov no rau "precision ua liaj ua teb" tau tsav qhov kev loj hlob tsis tu ncua ntawm 4-chlorobutyryl chloride hauv kev lag luam tshuaj tua kab.
Hauv thaj chaw ntawm cov ntaub ntawv polymer, 4-chlorobutyldichloride ua raws li "functionalization modifier". Nws tuaj yeem siv los tsim cov khoom siv siab tshaj -cov ntaub ntawv ua tau zoo xws li polyamides thiab polyesters los ntawm kev qhia cov tshuaj chlorine atoms, yog li ua kom cov cua sov ua haujlwm thiab tshuaj tiv thaiv corrosion ntawm cov ntaub ntawv. Piv txwv li, hauv kev lag luam aerospace, cov khoom siv polymers uas muaj 4-chlorobutyldichloride pawg tau siv los tsim cov khoom siv hluav taws xob hnyav thiab muaj zog, ua tau raws li qhov yuav tsum tau siv rau hauv qhov chaw huab cua.
Lub "Future Outlook" ntawm Kev Lag Luam Pillar
Niaj hnub no, 4-chlorobutyryl chloride tsis yog "cov khoom xav paub" hauv chav kuaj, tab sis yog ib feem tseem ceeb ntawm kev lag luam tshuaj lom neeg thoob ntiaj teb. Nws txoj kev xav tau kev lag luam txuas ntxiv nrog kev txhim kho sai ntawm kev lag luam xws li tshuaj, tshuaj tua kab, thiab cov ntaub ntawv tshiab. Raws li cov chaw tshawb fawb kev lag luam, hauv tsib xyoos tom ntej no, lub ntiaj teb kev lag luam loj ntawm 4-chlorobutyryl chloride yuav nthuav dav ntawm tus nqi txhua xyoo ntawm ntau dua 5%, nrog rau thaj tsam Asia-Pacific los ua lub zog tseem ceeb rau kev loj hlob.
Saib mus rau yav tom ntej, kev tshawb fawb thiab kev tsim kho kev taw qhia ntawm 4-chlorobutyryl chloride yuav tsom mus rau ob qhov chaw loj: Ua ntej, los ntawm kev siv tshuab catalytic, txhim kho txoj kev sib txuas ntxiv los txhim kho kev siv atomic thiab cov tshuaj tiv thaiv tawm los, ua tiav "zero emissions" ntau lawm; Thib ob, nthuav nws daim ntawv thov nyob rau hauv cov teb tshiab xws li lub zog tshiab thiab biomedicine, piv txwv li, ua ib qho ntxiv hauv lithium-ion roj teeb electrolytes lossis cov khoom siv hluavtaws rau cov neeg nqa khoom kho mob. Cov kev tsim kho tshiab no yuav tsav 4-chlorobutyryl chloride los txhim kho los ntawm "tus ncej kev lag luam" mus rau "cov khoom siv tshiab", pab txhawb kev loj hlob ntawm tib neeg lub neej.
Irreplaceability tsom xam
4-Chlorobutyryl Chlorideyog ib qho acylation reagent uas muaj zog heev, ua kom pom cov yam ntxwv tshwj xeeb thiab tsis tuaj yeem hloov pauv hauv cov tshuaj, tshuaj tua kab, thiab cov organic synthesis. Lub synergistic nyhuv ntawm acyl chloride pawg (-COCl) thiab cov tshuaj chlorine atom (-Cl) nyob rau hauv nws cov qauv molecular endows nrog tsis tshua muaj siab reactivity thiab selectivity, ua rau nws yog ib tug tseem ceeb lub cuab tam rau tsim complex molecular qauv. Cov hauv qab no muab kev soj ntsuam hauv - qhov tob ntawm nws qhov tsis tuaj yeem hloov pauv los ntawm peb qhov loj me: cov yam ntxwv ntawm kev ua haujlwm, cov ntawv thov scenarios, thiab cov qauv kev lag luam.
Cov yam ntxwv txuj ci: Kev ua haujlwm siab thiab kev xaiv los tsim cov teeb meem tseem ceeb
Cov pab pawg acyl ntawm 4-chlorobutyldichloride muaj cov khoom siv hluav taws xob muaj zog heev thiab tuaj yeem ua haujlwm zoo nrog cawv thiab amines los tsim cov khoom ester lossis amide. Cov tshuaj tiv thaiv no tuaj yeem ua tau raws li qhov mob me me, nrog tsawg los ntawm - cov khoom lag luam thiab cov txiaj ntsig siab. Piv txwv li, nyob rau hauv cov synthesis ntawm haloperidol (ib butyrylbenzene-raws li tshuaj antipsychotic), 4-chlorobutyldichloride tau qhia nrog cov pab pawg ua haujlwm tshwj xeeb los ntawm cov tshuaj tiv thaiv acylation, muab cov chaw ua haujlwm rau kev hloov kho molecular tom ntej. Yog tias siv lwm cov acylation reagents, yuav tsum muaj cov tshuaj tiv thaiv nruj dua (xws li qhov kub thiab txias) yuav tsum tau, lossis cov txiaj ntsig ntawm cov khoom lag luam yuav txo qis.
Tsis tas li ntawd, cov tshuaj chlorine atom ntawm 4-chlorobutyldichloride tuaj yeem koom nrog kev hloov pauv nucleophilic, ntxiv nthuav nws txoj hauv kev tawm tsam. Piv txwv li, hauv kev sib txuas ntawm qee yam tshuaj tua kab uas muaj cov tshuaj chlorine, nws tuaj yeem qhia cov pab pawg tshwj xeeb los ntawm kev hloov pauv ntawm cov tshuaj chlorine atom, txhim kho cov tshuaj lom neeg ntawm cov tshuaj tua kab. Qhov no "dual reactivity" muab nws yooj yooj yim nyob rau hauv molecular tsim thiab ua rau nws nyuaj rau hloov los ntawm ib tug functional reagent.
Daim Ntawv Thov Scenario: Rigid Demand hauv Pharmaceutical and Pesticide Industries
Kev lag luam kws tshuaj
4-Chlorobutyryl chloride yog ib qho tseem ceeb nruab nrab ntawm kev sib txuas los tiv thaiv-cov tshuaj qog nqaij hlav, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob. Noj fluphenazine ua piv txwv, nws cov nyhuv antagonistic ntawm dopamine receptors yog 20-40 npaug ntawm chlorpromazine, ua rau nws muaj peev xwm txo qis cov tshuaj tiv thaiv kev puas siab puas ntsws . 4-Chlorobutyryl chloride muab cov tub ntxhais tawg rau lub molecular molecular ntawm fluphenazine los ntawm cov tshuaj tiv thaiv acylation. Yog tias hloov nrog lwm tus neeg nruab nrab, txoj kev sib txuas yuav tsum raug kho dua tshiab, nce kev tshawb fawb thiab txhim kho cov nqi thiab cov voj voog. Ntxiv mus, nyob rau hauv kev tshawb fawb thiab kev loj hlob ntawm cov tshuaj tiv thaiv kab mob, 4-Chlorobutyryl chloride yuav siv tau los tsim amide bonds, muab kev ruaj ntseg thiab lom rau cov tshuaj molecules. Nws lub luag haujlwm tsis tuaj yeem hloov pauv.
Kev lag luam tshuaj tua kab
4-Chlorobutyryl chloride yog ib qho tseem ceeb raw khoom rau synthesizing herbicides thiab tshuaj tua kab. Piv txwv li, qee yam tshuaj tua kab mob tshiab txhim kho lub hom phiaj thiab kev pheej hmoo ntawm cov nroj tsuag los ntawm kev qhia txog 4-chlorobutyryl pawg, thaum txo qhov cuam tshuam rau cov kab mob uas tsis yog hom phiaj. Qhov kev thov "precision ua liaj ua teb" no tau tsav qhov kev loj hlob tsis tu ncua ntawm 4-Chlorobutyryl chloride hauv khw tshuaj tua kab. Yog tias siv lwm cov acylation reagents, cov qauv molecular yuav tsum tau hloov kho kom muaj kev ua haujlwm lom neeg, ua rau muaj kev tshawb fawb thiab kev loj hlob ntxiv.
Kev Lag Luam Kev Lag Luam: Kev Loj Hlob thiab Kev Txhim Kho Hauv Cheeb Tsam Kev Cuam Tshuam Txhim Kho Irreplaceability
Kev lag luam thoob ntiaj teb loj ntawm 4-Chlorobutyryl chloride yuav tsum nce los ntawm kwv yees li 150 lab rau 200 lab US las hauv 2023 txog 220 lab rau 300 lab US las hauv 2032, nrog rau kev loj hlob txhua xyoo (CAGR) ntawm 4.3%-4.5%. Qhov kev loj hlob no feem ntau yog tsav los ntawm kev xav tau nruj hauv kev lag luam tshuaj thiab tshuaj tua kab. Cov cheeb tsam Asia-Pacific, tshwj xeeb tshaj yog Tuam Tshoj thiab Is Nrias teb, nrog lawv cov chaw muag tshuaj thiab kev ua liaj ua teb loj, tau dhau los ua cov neeg siv khoom lag luam tseem ceeb rau 4-Chlorobutyryl chloride. Piv txwv li, qhov kev thov rau cov tshuaj antipsychotic xws li fluphenazine nyob rau hauv Tuam Tshoj tseem loj hlob, ncaj qha tsav tsheb ntshuam thiab zus tau tej cov 4-Chlorobutyryl chloride.
Tsis tas li ntawd, kev siv thev naus laus zis ntawm 4-chlorobutyryl chloride muaj qhov pib siab heev. Tam sim no, txoj hauv kev zoo tshaj plaws hauv Suav teb yog siv ib qho - kauj ruam kev sib txuas ntawm -butanone thiab thionyl chloride. Txawm li cas los xij, cov txheej txheem no tseem muaj teeb meem xws li cov tshuaj tiv thaiv kub thiab tsis tshua muaj txiaj ntsig. Kev txhim kho thev naus laus zis yuav tsum tau siv sijhawm ntev - kev nqis peev hauv kev tshawb fawb thiab kev tsim kho, thiab nws nyuaj rau kev sib tw los ntawm cov nqi qis hauv lub sijhawm luv. Qhov teeb meem thev naus laus zis no thiab kev lag luam concentration tau ntxiv dag zog rau txoj haujlwm tsis tuaj yeem hloov pauv ntawm 4-chlorobutyryl chloride.
Yav Tom Ntej Outlook: Nthuav Tus Nqi Ciam Teb los ntawm Cov Ntawv Thov Tshiab
Nrog rau kev nce qib ntawm cov organic synthesis thev naus laus zis, daim ntawv thov Scope ntawm 4-Chlorobutyryl Chloride tau nthuav dav los ntawm thaj chaw ib txwm muaj mus rau cov tshiab. Piv txwv li, nyob rau hauv lub tshav pob ntawm lub zog tshiab, nws yuav siv tau raws li ib tug additive nyob rau hauv lithium-ion roj teeb electrolytes los txhim kho roj teeb kev ua tau zoo; nyob rau hauv lub teb ntawm biomedicine, nws muaj peev xwm yuav ua hauj lwm los mus tsim synthesize tseem ceeb intermediates rau gene therapy carriers, txhawb txoj kev loj hlob ntawm precision tshuaj. Cov ntawv thov tshiab no yuav ntxiv dag zog rau qhov tsis tuaj yeem hloov pauv ntawm 4-chlorobutyldichloroform thiab muab lub zog tshiab rau nws txoj kev lag luam loj hlob.
Cim npe nrov: 4-chlorobutyryl chloride cas 4635-59-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom