Fmoc-D-Tyr(tBu)-OH, tseem hu ua Fmoc-O-tert-butyl-D- tyrosine, yog cov tshuaj sib xyaw nrog cov qauv tshwj xeeb thiab ntau daim ntawv thov hauv thaj chaw chemistry thiab biochemistry. Nws yog tyrosine derivative nrog Fmoc (fluorenylmethoxycarbonyl) tiv thaiv pawg txuas nrog cov amino pawg thiab tert -butyl (tBu) pab pawg tiv thaiv phenolic hydroxyl pawg. Cov pab pawg Fmoc feem ntau yog siv hauv cov khoom siv -theem peptide synthesis vim nws yooj yim ntawm kev tshem tawm nyob rau hauv me me alkaline tej yam kev mob. Cov pab pawg tert-butyl, ntawm qhov tod tes, tiv thaiv phenolic hydroxyl pab pawg los ntawm cov tshuaj tiv thaiv tsis xav tau, txhim kho kev ruaj ntseg thiab rov ua haujlwm ntawm cov molecule.
 |
 |
|
Tshuaj Formula |
C28H29NO5 |
|
Exact Mass |
459.20 |
|
Molecular Luj |
459.54 |
|
m/z |
459.20 (100.0%), 460.21 (30.3%), 461.21 (4.4%), 461.21 (1.0%) |
|
Elemental Analysis |
C, 73.18; H, 6.36; N, 3.05; O, 17.41 |
Peptide Synthesis
- Khoom -Phase Peptide Synthesis (SPPS): Ua haujlwm tseem ceeb hauv SPPS vim nws Fmoc tiv thaiv pawg. Fmoc pab pawg ua kom muaj txiaj ntsig zoo sib txuas thiab tuaj yeem tshem tawm yooj yim nyob rau hauv me me alkaline tej yam kev mob, ua rau nws zoo tagnrho rau cov synthesis ntawm complex peptides thiab proteins. Daim ntawv thov no yog siv dav hauv kev tshawb fawb thiab kev lag luam chaw tsim khoom ntawm bioactive peptides thiab cov proteins.
Kev tshawb fawb biomedical
- Precursor hauv Hormone thiab Neurotransmitter Synthesis: Nws yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm ntau yam tshuaj hormones thiab neurotransmitters, xws li thyroxine, dopamine, thiab adrenaline. Cov tshuaj hormones thiab neurotransmitters ua lub luag haujlwm tseem ceeb hauv kev tswj cov txheej txheem metabolic, mus ob peb vas, kev paub txog kev ua haujlwm, thiab kev ua haujlwm ntawm lub cev. Los ntawm kev koom nrog lawv cov synthesis, nws tsis ncaj qha rau kev tswj hwm homeostasis thiab kev ua haujlwm ntawm ntau yam kab mob lom.
- Proteomics Studies: Nws cov qauv tshwj xeeb thiab kev ua haujlwm ua rau nws muaj txiaj ntsig zoo rau kev kawm cov qauv protein, kev ua haujlwm, thiab kev sib cuam tshuam. Cov kws tshawb fawb tuaj yeem siv nws los qhia txog kev hloov kho lossis cov cim npe rau hauv cov protein, ua rau kev tshawb nrhiav cov protein-cov protein sib cuam tshuam, tom qab- hloov pauv kev hloov pauv, thiab lwm yam txheej txheem lom neeg.
Kev lag luam kws tshuaj
- Kev Tshawb Nrhiav Tshuaj thiab Kev Txhim Kho: Lub peev xwm los koom rau hauv cov synthesis ntawm cov tshuaj hormones thiab neurotransmitters ua rau nws ib tug txaus nyiam pib taw tes rau txoj kev loj hlob ntawm tshiab kho cov neeg sawv cev. Cov tuam txhab muag tshuaj tuaj yeem tshawb nrhiav nws lub peev xwm hauv kev txhim kho cov tshuaj tsom rau cov kab mob neurological lossis endocrine.
Kev Tshawb Fawb Txog Kev Tshawb Fawb
- Kev soj ntsuam biochemical thiab kev sim: Nws yog siv nyob rau hauv ntau yam kev ntsuam xyuas biochemical thiab kev sim los kawm txog cov txheej txheem hauv qab cov tshuaj hormones thiab neurotransmitter ntau lawm, kev tswj hwm, thiab kev ua haujlwm. Cov kev tshawb fawb no tuaj yeem muab cov kev pom muaj txiaj ntsig rau hauv cov hauv paus ua rau cov kab mob thiab cov teeb meem cuam tshuam nrog cov tshuaj hormones thiab neurotransmitter imbalances.
Cov ntsiab lus tseem ceeb & cov ntaub ntawv siv
Cov Khoom Siv Tiv Thaiv Tus Kheej (PPE)
- Hnav Tshuaj-Cov hnab looj tes tiv taus: Tiv thaiv koj txhais tes los ntawm kev sib cuag nrog cov tshuaj. Nitrile lossis neoprene hnab looj tes feem ntau pom zoo.
- Kev Tiv Thaiv Qhov Muag: Siv cov tshuaj txhuam hniav los yog daim npog ntsej muag kom tiv thaiv qhov muag tsis pom kev.
- Khaub ncaws: Hnav cov khaub ncaws tiv thaiv uas npog koj ob txhais caj npab thiab txhais ceg kom txo tau cov tawv nqaij.
- Kev tiv thaiv ua pa: Yog tias ua haujlwm nrog cov khoom siv siab lossis tsim cov plua plav, xav txog kev hnav lub tshuab ua pa uas pom zoo rau qhov xwm txheej tshwj xeeb. Txawm li cas los xij, nco ntsoov tias kev siv niaj hnub yuav tsis tas yuav tsum muaj kev tiv thaiv ua pa tshwj tsis yog cov xwm txheej tshwj xeeb tau lees paub.
Kev cia khoom
- Kev Tswj Kub Kub: Khaws rau hauv qhov chaw txias, qhuav, nyiam dua ntawm 2-8 degree. Tsis txhob raug kub hnyiab lossis tshav ntuj ncaj qha.
- Container Integrity: Khaws lub thawv kaw kom nruj kom tsis txhob ya raws thiab kis kab mob.
- Txee lub neej: Txheeb xyuas cov khoom hnub tas sij hawm thiab ua raws li kev pom zoo khaws cia kom ntseeg tau tias lub neej txee zoo.
Kev Tiv Thaiv Kev Tiv Thaiv
- Txo qhov raug: Kov hauv qhov dej - qhov chaw cua kom txo tau qhov kev pheej hmoo ntawm kev nqus pa.
- Zam kev tsim cov hmoov av: Tsis txhob ua tej yam uas yuav ua rau muaj plua plav, xws li kev sib tsoo lossis crushing cov khoom. Siv cov txheej txheem tsim nyog los txo cov hmoov av tsawg.
- Kev sib haum xeeb: Paub txog cov tshuaj sib xyaw nrog lwm cov tshuaj. Tsis txhob sib xyaw nrog cov tshuaj tsis sib xws lossis cov khoom siv.
Cov txheej txheem xwm txheej ceev
- Inhalation: Yog tias nqus tau, txav tus neeg mus rau huab cua ntshiab tam sim ntawd thiab nrhiav kev kho mob yog tias tsim nyog.
- Daim tawv nqaij tiv tauj: Tshem tawm cov khaub ncaws uas tsis huv tam sim ntawd thiab ntxuav qhov chaw raug mob kom huv si nrog xab npum thiab dej. Nrhiav kev kho mob yog tias khaus khaus tshwm sim.
- Qhov muag tiv tauj: Yaug qhov muag tam sim nrog cov dej ntau yam tsawg kawg 15 feeb. Tshem tawm cov iav tiv thaiv, yog tias ua tau yooj yim, thiab txuas ntxiv yaug. Nrhiav kev kho mob yog tias khaus tshwm sim.
- Noj: Tsis txhob ntuav. Yaug lub qhov ncauj nrog dej thiab nrhiav kev kho mob.
Pov tseg pov tseg
- Kev pov tseg kom raug: Pov tseg thiab nws cov khoom pov tseg raws li cov cai hauv zos thiab cov lus qhia. Tham nrog koj lub chaw saib xyuas cov pov tseg hauv zos rau cov lus qhia tshwj xeeb.
- Environmental Considerations: Tsis txhob tso cov tshuaj lossis nws cov khoom pov tseg rau hauv ib puag ncig, suav nrog cov kav dej thiab cov kav dej phwj tuaj.
Cov ntaub ntawv ntxiv
- MSDS/SDS Review: Ua ntej siv, tshuaj xyuas Cov Ntaub Ntawv Kev Nyab Xeeb Cov Ntaub Ntawv (MSDS) lossis Daim Ntawv Qhia Txog Kev Nyab Xeeb (SDS) muab los ntawm cov chaw tsim khoom. Cov ntaub ntawv no muaj cov ncauj lus qhia ntxaws txog kev phom sij, kev tiv thaiv kev tiv thaiv, cov txheej txheem xwm txheej ceev, thiab cov txheej txheem pov tseg.
- Kev cob qhia: Xyuas kom meej tias txhua tus neeg ua haujlwm tuav nws tau txais kev cob qhia kom raug ntawm nws txoj kev tuav ruaj ntseg thiab siv.
Fmoc-D-Tyr(tBu)-OH hauv kev tshawb nrhiav tshuaj thiab kev loj hlob
Raws li ib tug tshuaj precursor:
Nws muaj peev xwm ua haujlwm lom neeg thiab tuaj yeem siv los ua qhov sib xyaw ua ntej rau cov tshuaj tshiab. Los ntawm kev hloov kho lossis hloov pauv nws, cov khoom sib txuas tshiab nrog kev ua kom muaj zog lom neeg lossis cov tshuaj zoo dua tuaj yeem tau txais.
Kev koom tes hauv kev tsim tshuaj molecular:
Hauv kev tsim tshuaj molecule, Nws tuaj yeem siv los ua ib qho tseem ceeb hauv chav tsev los ua ke nrog lwm cov tshuaj los yog moieties los tsim cov tshuaj molecules tshiab nrog cov haujlwm tshwj xeeb thiab kev ua ub no.
Txhim kho kev xaiv tshuaj thiab lub hom phiaj:
Los ntawm kev qhiaFmoc-D-Tyr(tBu)-OHrau hauv cov tshuaj molecules, kev xaiv tshuaj thiab lub hom phiaj tuaj yeem txhim kho kom lawv tuaj yeem ua tau zoo dua ntawm cov hom phiaj lom neeg, yog li ua kom cov txiaj ntsig kho tau zoo thiab txo cov kev mob tshwm sim.
Synthesis ntawm cov tshuaj tshiab A:
Siv nws los ua cov khoom pib lossis qhov tseem ceeb nruab nrab, cov kws tshawb fawb tau tsim cov tshuaj tshiab A nrog cov qauv tshuaj tshiab thiab cov tshuaj lom neeg los ntawm cov tshuaj lom neeg (xws li, esterification, amidation, hloov pauv, thiab lwm yam).
Cov kev tshawb fawb ntxiv tau pom tias cov txheej txheem ntawm kev ua ntawm cov tshuaj tshiab A yog txhawm rau cuam tshuam cov teeb liab thiab cov txheej txheem metabolic ntawm cov qog hlwb los ntawm kev khi rau cov receptors tshwj xeeb ntawm cov qog hlwb, yog li ua tiav cov nyhuv tiv thaiv - qog.
Kev tshawb fawb txog kev tsim:
Cov ntawv sau npe tuaj yeem siv tau hauv X-ray crystallography, nuclear magnetic resonance (NMR) lossis lwm yam kev ua haujlwm biology los daws lawv cov qauv peb -dimensional. Cov tswv yim no tuaj yeem nthuav qhia kev sib cuam tshuam thiab kev npaj ntawm atoms hauv cov protein, yog li muab cov ntaub ntawv tseem ceeb txog cov qauv thiab kev ua haujlwm ntawm cov protein.
Kev tshawb fawb ua haujlwm:
Los ntawm kev soj ntsuam tus cwj pwm ntawm tagged proteins nyob rau hauv ib lub cell los yog kab mob, cov kws tshawb fawb tuaj yeem nkag siab txog cov txheej txheem ntawm lawv cov kev ua hauv cov txheej txheem lom neeg. Piv txwv li, lawv tuaj yeem siv fluorescence microscopy los soj ntsuam qhov chaw hauv cheeb tsam thiab kev hloov pauv ntawm cov ntawv sau cov protein hauv cov hlwb, lossis txiav txim siab lawv cov kev cuam tshuam nrog lwm cov molecules thiab enzyme kev ua ub no los ntawm kev sim biochemical.
Cov ntawv thov Case
Piv txwv tias cov kws tshawb fawb xav paub txog cov qauv thiab kev ua haujlwm ntawm cov cim qhia cov protein, lawv tuaj yeem siv tauFmoc-D-Tyr(tBu)-OHraws li ib tug marker yuav tsum tau muab tso rau hauv ib qho chaw tshwj xeeb ntawm cov protein.
Tom qab ntawd lawv tau siv X-ray crystallography los daws qhov peb- qauv qauv ntawm cov ntawv sau npe protein thiab pom tias cov protein muaj qhov chaw tshwj xeeb.
kev faib tawm channel
Fmoc-D-Tyr(tBu)-OH,Suav lub npe yog Fmoc-O-tert-butyl-D-tyrosine, uas yog ib qho tseem ceeb biochemical reagent nrog dav siv nyob rau hauv peptide synthesis, tshuaj tsim kho, thiab lwm yam teb. Nws cov kev muag khoom yog dav, npog ntau yam kev tshaj lij tshuaj reagent cov chaw muag khoom, biopharmaceutical technology tuam txhab, thiab cov chaw tshawb fawb hauv tsev thiab txawv teb chaws. Hauv qab no yog cov ncauj lus kom ntxaws tsom xam ntawm nws qhov kev muag khoom channel:
Cov yam ntxwv thiab qhov zoo ntawm kev muag khoom
Kev sib txawv
Nws cov kev muag khoom muaj ntau haiv neeg, suav nrog cov vev xaib raug cai, e- kev lag luam platforms, kev koom tes nrog cov neeg siv khoom, kev nthuav qhia, thiab lwm yam. Qhov kev sib txawv no tso cai rau cov neeg siv khoom xaiv txoj kev yuav khoom zoo tshaj plaws raws li lawv tus kheej xav tau thiab nyiam.
Yooj yim
Nrog rau kev txhim kho hauv Is Taws Nem, ntau thiab ntau tus neeg muag khoom pib muag los ntawm cov vev xaib raug cai thiab e- lag luam platforms. Cov neeg siv khoom tuaj yeem tshawb xyuas cov ntaub ntawv khoom, tso xaj, thiab taug qab cov xwm txheej hauv online txhua lub sijhawm thiab nyob qhov twg, txhim kho kev yuav khoom zoo heev.
Kev tshaj lij
Ntau tus neeg muag khoom muab kev txhawb nqa kev tshaj lij thiab tom qab - kev muag khoom thaum muag. Lawv tuaj yeem muab cov kev daws teeb meem raws li qhov xav tau ntawm cov neeg siv khoom, pab lawv daws teeb meem thaum siv.
Internationalization
Qee lub npe nrov thoob ntiaj teb xws li SCSTANDARD muag lawv cov khoom thoob ntiaj teb los ntawm cov neeg sawv cev thiab cov neeg xa khoom. Txoj kev muag khoom thoob ntiaj teb no ua rau nws yooj yim dua rau cov neeg siv khoom kom tau txais cov khoom siab tshaj -cov khoom zoo thiab kev txhawb nqa.
Txoj kev loj hlob ntawm kev muag khoom channel
Kev loj hlob ntawm kev muag khoom hauv online
Nrog rau kev vam meej tas mus li thiab nrov ntawm Internet technology, kev muag khoom hauv online yuav dhau los ua qhov tseem ceeb ntawm kev muag khoom yav tom ntej. Cov neeg muag khoom tuaj yeem nthuav lawv cov kev muag khoom hauv online, txhim kho kev muag khoom thiab kev txaus siab ntawm cov neeg siv khoom los ntawm kev tsim cov vev xaib raug cai thiab koom nrog e- kev lag luam platforms.
Qhov nce ntawm cov kev pabcuam customized
Nrog rau kev sib txawv thiab kev tsim kho tus kheej ntawm cov neeg siv khoom xav tau, cov kev pabcuam customized yuav dhau los ua ib qho tseem ceeb rau kev muag khoom yav tom ntej. Cov neeg muag khoom tuaj yeem muab cov khoom lag luam customized thiab kev txhawb nqa raws li cov neeg siv khoom xav tau kom tau raws li lawv cov kev xav tau tshwj xeeb.
Txhim khu kev koom tes thoob ntiaj teb
Nrog rau txoj kev loj hlob sai ntawm globalization, kev koom tes thoob ntiaj teb thiab kev sib pauv yuav dhau los ua ntu zus. Nyob rau hauv lub neej yav tom ntej, ntau cov neeg muag khoom hauv tsev yuav nquag nrhiav kev koom tes nrog cov npe nrov thoob ntiaj teb los koom ua ke nthuav thoob ntiaj teb kev ua lag luam thiab txhim kho kev sib tw thoob ntiaj teb ntawm lawv cov khoom.
Kev txhawb nqa technology tshiab
Kev tsim kho thev naus laus zis yog ib qho tseem ceeb tsav lub zog rau kev txhim kho ntawm qhov kev muag khoom no. Cov neeg siv khoom tuaj yeem txhim kho qhov zoo thiab kev ua tau zoo ntawm lawv cov khoom los ntawm kev tsim cov khoom tshiab thiab txhim kho cov txheej txheem ntau lawm, yog li nyiam cov neeg siv khoom ntau dua thiab txhim kho kev lag luam kev sib tw.
Lub 'Rebellion' ntawm Fmoc-D-Tyr (tBu) - OH Function: Los ntawm Metabolic Inert mus rau Stable Kernel
Nyob rau hauv lub ntiaj teb microscopic ntawm peptide synthesis thiab kev tsim tshuaj, Fmoc-D-Tyr (tBu) - OH zoo li ib qho tshwj xeeb "tshuaj pearl", thiab nws cov khoom siv tau tas li rov hais dua hauv kev tshawb fawb tshawb fawb. Los ntawm thawj zaug ntseeg tias muaj cov metabolism hauv inertness, mus rau tam sim no tau qhia tias muaj lub luag haujlwm tseem ceeb hauv kev ruaj khov ntawm cov tub ntxhais kawm, qhov kev hloov pauv no tsis tsuas yog cuam tshuam cov kev paub ib txwm muaj, tab sis kuj qhib txoj hauv kev tshiab rau kev tsim, kev sib txuas, thiab kev siv tshuaj peptide.
Keeb kwm tsim
Hauv kev tshawb fawb thaum ntxov ntawm Fmoc-D-Tyr (tBu) - OH, cov kws tshawb fawb tau tsom mus rau nws daim ntawv thov hauv peptide synthesis. Vim muaj cov pab pawg Fmoc thiab tBu, qhov sib xyaw no suav hais tias nyuaj rau kev lees paub thiab metabolized los ntawm enzymes hauv vivo. Enzymes feem ntau muaj cov chaw ua haujlwm tshwj xeeb thiab cov chaw sib txuas hauv substrate. Rau cov tebchaw nrog cov pab pawg tiv thaiv nyuaj, lawv cov qauv spatial thiab tshuaj lom neeg sib txawv ntawm cov substrates, ua rau nws nyuaj rau kev cuam tshuam nrog cov enzymes. Raws li qhov kev nkag siab no, cov kws tshawb fawb xav tias Fmoc-D-Tyr (tBu) - OH muaj cov metabolism hauv inertness, txhais tau tias nws tsis tawg sai sai lossis hloov pauv hauv cov kab mob uas muaj sia nyob thiab muaj peev xwm tswj tau tus qauv ruaj khov.
Kev tshawb fawb Basis
Qee qhov kev soj ntsuam ntawm lub sijhawm ntawd tau muab qee lub hauv paus rau qhov kev xav no. Piv txwv li, hauv kev sim hauv vitro cell, Fmoc-D-Tyr (tBu) - OH tau ntxiv rau hauv cov kab lis kev cai ntawm tes, thiab tom qab lub sijhawm cog qoob loo, nws tau tshawb pom los ntawm cov txheej txheem tshuaj ntsuam xws li kev ua haujlwm siab ua kua chromatography (HPLC) uas cov concentration ntawm cov compound hauv hlwb hloov me ntsis thiab tsis muaj cov khoom degradation tseem ceeb. Tsis tas li ntawd, hauv kev sim tsiaj, kev faib tawm thiab cov metabolism hauv Fmoc-D-Tyr (tBu) - OH hauv vivo raug kuaj pom tom qab txhaj tshuaj lossis tswj qhov ncauj. Nws kuj tau pom tias qhov sib xyaw ua ke muaj ib nrab ntev dua - lub neej thiab qeeb qeeb metabolism hauv vivo. Cov txiaj ntsig kev sim no ntxiv txhawb qhov kev pom tias Fmoc-D-Tyr (tBu) - OH muaj cov metabolism hauv inertness.
Qhov cuam tshuam rau peptide synthesis
Raws li qhov kev xav ntawm metabolic inertness, Fmoc-D-Tyr (tBu) - OH yog siv dav hauv peptide synthesis. Hauv cov khoom-theem peptide synthesis, nws yog ib qho tseem ceeb tiv thaiv amino acid, kom ntseeg tau tias tyrosine residues tsis hloov ntxov ntxov los yog degraded thaum lub sij hawm synthesis. Piv txwv li, thaum synthesizing peptides uas muaj ntau yam tyrosine residues, kev siv Fmoc-D-Tyr (tBu) - OH tuaj yeem zam cov tshuaj tiv thaiv ntawm phenolic hydroxyl pab pawg ntawm tyrosine thiab lwm cov reagents thaum lub sij hawm synthesis txheej txheem, yog li ua kom cov peptide zoo thiab yield. Tsis tas li ntawd, vim nws cov metabolic inertness, cov synthesized peptides ruaj khov dua thaum lub sij hawm tom qab purification thiab cia cov txheej txheem, txo qhov poob los ntawm compound degradation.
Cim npe nrov: fmoc-d-tyr(tbu)-oh cas 118488-18-9, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom