FMOC - glu (OBZL) {{} Oh HU 123639-61-2
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FMOC - glu (OBZL) {{} Oh HU 123639-61-2

FMOC - glu (OBZL) {{} Oh HU 123639-61-2

Khoom Code: BM-2-1-365
Naj Npawb: 123639-61-2
Molecular Cov Qauv: C27H25No6
Molecular hnyav: 459.49
Einecs tus naj npawb: /
MDL tsis muaj.: MFCD00065642
HS code: 2924 29 70
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BOUAB TECH XI'AN HOOBKAS
Kev Pab Technology: R & Dept.-1

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm fmoc-}}} 2 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale mis zoo fmoc-glu (OBZL) -H CAS 123639-61-2 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

 

FMOC - glu (OBZL) {{1} hyog ib qho tseem ceeb dual -} tiv thaiv glutamic acid derivative hauv cov khoom-}} itionase peptide synthesis. Nws tus qauv tsim ingeniousiously ua tiav kev tswj hwm sab saw thiab cov saw tej main functamic ntawm glutamic acid. Cov moleecule no ua haujlwm fluorene methoxycarbonyl (fmoc) raws li kev tiv thaiv pab pawg rau kev tiv thaiv piperidide me me, kom tau txais kev tiv thaiv me me ntawm cov txheej txheem hluavtaws vam meej. Lub caij no, sab saw txaij carboxyl pawg yog tiv thaiv tas mus li Benzyl Ester (OBZL). Cov phiaj xwm no tiv thaiv Intramolecular Cyclization uas yuav tsim pyroglutamic acid los yog seem sab saw hla thaum lub sij hawm peptide saw sib dhos. Qhov kev tiv thaiv no ua rau nws lub tsev tseem ceeb rau kev siv cov kev ua haujlwm zoo li qub, xws li npaj cov qauv roj av, lossis cov khoom siv roj av ntxiv). Tom qab thawj cov saw kawg synthesis ua tiav, lub ntiaj teb tsis muaj zog nyob rau hauv kev txhim kho glutamatic probe, thiab cov tshuaj tiv thaiv kab mob, thiab cov protein mimics.

product-339-75

 

Fmoc-Glu(OBzl)-OH CAS 123639-61-2 | Shaanxi BLOOM Tech Co., Ltd Fmoc-Glu(OBzl)-OH CAS 123639-61-2 | Shaanxi BLOOM Tech Co., Ltd

Tshuaj Cov Qauv

C7h3Cln2o2

Muaj pes tsawg leej

182

Molecular hnyav

183

m/z

182 (100.0%), 184 (32.0%), 183 (7.6%), 185 (2.4%)

Kev Ntsuam Xyuas

C, 46.05; H, 1.66; Cl, 19.42; N, 15.34; O, 17.53

Applications

Fmoc-Glu(OBzl)-OH CAS 123639-61-2 Applications | Shaanxi BLOOM Tech Co., Ltd

Peptide synthesis

Cov khoom - theem peptide synthesis (SPPS):

  • Serves as an important intermediate in solid-phase peptide synthesis, a widely used technique for the synthesis of peptides and proteins.
  • FMOc pawg, ua kev tiv thaiv pab pawg rau pawg amino, pab txhawb kev sib txuas ntawm cov amino acids thaum lub sijhawm synthesis.
  • Tom qab cov kev xav tau yog sib sau ua ke, FMOc pab pawg tuaj yeem raug tshem tawm hauv cov pab pawg me me, qhia cov pab pawg dawb rau kev xav tau ntxiv lossis cov kauj ruam lim dej ntxiv.

Kws Tshuaj Kho Mob

  • Cov tshuaj ntsuam kev lag luam ntau ntawm cov synthesis ntawm bioaction peptides thiab cov protein rau kev txhim kho cov tshuaj uas yog cov tshuaj uas kho.
  • Raws li ib qho tseem ceeb nruab nrab, ua si lub luag haujlwm tseem ceeb hauv cov synthesis ntawm xws li cov tebchaw, ua kom cov khoom sib txuas nrog cov kev sib txuas ua ke.
Fmoc-Glu(OBzl)-OH CAS 123639-61-2 Applications | Shaanxi BLOOM Tech Co., Ltd
Fmoc-Glu(OBzl)-OH CAS 123639-61-2 Applications | Shaanxi BLOOM Tech Co., Ltd

Tshawb nrhiav cov ntawv thov

  • Hauv cov kev tshawb fawb biochemical thiab tshuaj lom neeg cov tshuaj lom neeg, nws ua haujlwm ua cov khoom muaj protein}}} cov protein, thiab lwm cov txheej txheem biological.
  • Nws siv nyob rau hauv synthesis ntawm daim ntawv lo lossis hloov kho peptides lossis muab cov kws tshawb fawb los sojntsuam cov txheej txheem no nrog kev tshwj xeeb thiab rhiab.

Protein Engineering

  • Protein engineering, uas muaj feem cuam tshuam cov kuab tshuaj thiab kev hloov kho protein kom txhim kho lawv cov haujlwm tshiab lossis feem ntau yuav tsum muaj cov khoom siv peptides thiab protein ntau.
  • Nrog nws cov qauv tshwj xeeb nta, tuaj yeem koom rau hauv cov qauv tsim los ua tiav cov khoom xav tau.
Fmoc-Glu(OBzl)-OH CAS 123639-61-2 Applications | Shaanxi BLOOM Tech Co., Ltd

 

 

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FMOC - l} l {glutamic acid {} {4} {{4} {{4} {{4} {{4} {{4} {{4} {{4} . 123639-61-2} Hauv qab no yog cov piv txwv rau cov piv txwv los qhia nws cov ntawv thov hauv cov tshuaj molecules thiab kuaj mob:

 

Siv raws li cov tshuaj lwg yeeb yaj kiab rau kev kho mob ntawm cov kab mob

Kev Tiv Thaiv Cov Pawg thiab Tshuaj Kho Mob: Nws tsuas yog siv hauv cov khoom siv protein los tiv thaiv cov amino pab pawg ntawm cov khoom siv tshuaj lom neeg ntxiv. Qhov kev tiv thaiv no yog qhov tseem ceeb hauv peptide synthesis, cia cov kws tshawb nrhiav kom tswj tau meej thiab ua kom cov qauv ntawm peptides.

Kev txhim kho yeeb tshuaj: Peptides synthesized los ntawm fmoc - gamma- gramma} Piv txwv li, qee cov tshuaj peptide muaj peev xwm tuaj yeem ua rau cov txheej txheem tshwj xeeb lossis cov txheej txheem hauv cov kab mob muaj kab mob rau cov kab mob. Txawm hais tias cov piv txwv ntawm cov tshuaj peptide tshwj xeeb siv rau hauv kev kho mob peptide yuav tsis tau muab cov tshuaj tiv thaiv peptide hauv cov oncology, neurological kab mob, thiab kis kab mob.

 

Siv raws li kev kuaj mob rau kev kuaj mob kab mob

Immunochemical tsom xam: Nrog rau cov tshuaj thev naus laus zis ntawm monoclonal immunoassay, luminescence immunoassay, thiab lwm yam kev siv tsis siv neeg tab tom nrhiav kom sai. Peptides cuam tshuam los ntawm nws tuaj yeem siv tau ua qhov tseem ceeb ntawm cov txheej txheem immunoassay rau kev kuaj mob ntawm cov kab mob. Piv txwv li, peptides tuaj yeem siv los ua antigens uas khi cov tshuaj tiv thaiv tshwj xeeb los tsim cov tshuaj tiv thaiv}}} Cov tshuaj tiv thaiv kab mob ntawm cov pathogens lossis biomarkers hauv ib qho qauv.

Kev sib cais biochemical thiab tsom xam: peptides kuj tseem siv tau los ua kev soj ntsuam lossis cov cim rau kev sib cais biochemical thiab tsom xam. Los ntawm kev siv cov kev sib cuam tshuam ntawm peptides nrog cov kev ua haujlwm tshwj xeeb (piv txwv li, enzyme, thiab lwm yam kev kuaj pom ntawm cov qauv biological. Ib qho ntxiv, peptides tuaj yeem siv raws li kev piav qhia txog cov duab tsiaj hauv biolules thiab cov duab thev naus laus zis rau kev kuaj mob thaum ntxov.

 

Hauv cov ntsiab lus, peptides synthesized los ntawm nws muaj ntau cov kev siv hauv kev kho cov kab mob, tab sis kuj yog cov tshuaj tiv thaiv kab mob rau kev kuaj mob ntawm cov kab mob. Cov ntawv thov no tsis tsuas yog txhim kho kev kho mob ntawm cov kab mob, tab sis kuj tseem tau muab txhais tau tias thiab cov txheej txheem kev kuaj mob thaum ntxov thiab tiv thaiv thaum ntxov thiab tiv thaiv cov kab mob thaum ntxov thiab tiv thaiv thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv mob thaum ntxov thiab tiv thaiv thaum ntxov thiab tiv thaiv thaum ntxov thiab tiv thaiv cov kab mob.

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FMOC - l} l} glutic acid {} gamya aczylen {} Cov hauv qab no yog cov piv txwv ntawm nws daim ntawv thov hauv kev npaj ntawm biocompe cov ntaub ntawv thiab cov ntaub ntawv ntse:

Hais txog cov ntaub ntawv

 

Peptide Castic:
Peptides ua ke los ntawm nws tuaj yeem coated nyob rau saum npoo ntawm kev mob tshuaj tiv thaiv kev mob, xws li cov pob qij txha thiab cov khoom siv dag ntxias, txhawm rau txhim kho lawv cov biocompatibility.
Cov txheej txheem peptide no tuaj yeem txo cov lus teb rau kev cog lus ntawm kev cog thiab cov ntaub socaws thiab txhawb kev kho kom ruaj khov ntawm kev cog hniav thiab cov ntaub so ntswg kom zoo.

 

Cov ntaub so ntswg engineering:
Nyob rau hauv cov ntaub so ntswg engineering, peptides tuaj yeem siv los ua cell kab lis kev cai substrates lossis ua rau cov yam ntxwv los txhawb kev loj hlob ntawm tes, kev sib txawv thiab nqaij tsim.
Peptides cuam tshuam los ntawm nws tuaj yeem siv los tsim cov ntaub so ntswg ua cov pob kws tshwj xeeb, xws li cov tawv nqaij, pob txha, vim lawv cov kev ua haujlwm tshwj xeeb.

 

Cov ntaub ntawv ntse

Stimulus - Cov Khoom Siv:
FMOC - l} l} glutamic acid {} gamya aczester {}, kub, th, lwm yam).
Qhov kev ua tiav no tuaj yeem siv los npaj cov khoom ntse xws li tus kheej -} ntawv kho cov ntaub ntawv thiab cov ntaub ntawv cim xeeb. Cov ntaub ntawv no muaj peev xwm ua kom muaj kev hloov pauv ntawm lub cev lossis tshuaj lom neeg thaum raug rau sab nraud stimuli kom ua tiav cov cai thov kom muaj kev thov.

 

Molecular lees paub thiab hnov ​​tau:
Peptides kuj tseem siv tau los ua cov khoom siv rau cov kev lees paub molecular thiab hnov ​​los xyuas cov qauv keeb kwm lossis cov biomarkers hauv cov tsiaj muaj sia.
Peptides cuam tshuam los ntawm nws tuaj yeem hloov kho thiab hloov kho kom ua tiav cov kev xaiv siab thiab rhiab tau kom pom ntawm cov lwg me me. Qhov no nrhiav tau siv tau los npaj biosensors lossis bioimaging probes, uas tuaj yeem muab kev txhawb nqa haib rau kev kuaj mob thaum ntxov thiab kho cov kab mob.

 

Hauv cov ntsiab lus, fmoc - l} gamma} gamyl ester muaj ntau cov kev siv hauv kev txhim kho cov khoom tshiab ntawm cov khoom tshiab. Los ntawm kev siv nws cov txiaj ntsig hauv kev npaj cov ntaub ntawv thiab cov ntaub ntawv ntse, nws tuaj yeem muab kev tiv thaiv tshiab ntawm kev kho mob, kev tiv thaiv biotechnology thiab ib puag ncig. Lub caij no, nrog kev txhim kho txuas ntxiv thiab txhim kho ntawm cov khoom siv hluav taws xob peptide ntxiv raws li nws yuav tsim kho thiab siv rau yav tom ntej.

Cov kev tawm tsam

FMOC - glu (OBZL) {{1} h(FluorenyOrmethoxycarbonyl - glutamic hnyav 459.49 g / molecular tawv nqaij {1} Tus lej 43639- 61-2. Nws cov qauv yog tsim los ntawm cov esterification ntawm l-glutamic acid nrog benzyl pawg ntawm gamma carboxyl pawg, thiab cov lus qhia ntawm FMboxyl pawg, thiab cov lus qhia ntawm FMboxyl pawg, thiab cov kev tiv thaiv pab pawg, ua rau muaj cov hmoov dawb dawb. Lub solubility ntawm no compound hauv DMOPS yog qhov siab li 200 ML (435.27 mm), tab sis nws solubility hauv dej tsis tau qhia meej. Qhov chaw cia khoom yuav tsum tau nruj me ntsis kev tswj hwm ntawm -20℃(hmoov hauv cov kuab tshuaj yuav tsum yog -80℃(6 lub hlis) kom tsis txhob muaj kev lom zem lossis ploj ntawm kev ua ub no.

Kev faib tawm thiab kev siv hluav taws xob ntawm cov nyom

Kev tiv thaiv kab mob kom zoo

Sib cuag nrogFMOC - glu (OBZL) {{1} hHmoov yuav ua rau muaj kev npau taws hauv zos, tshwm sim li ntawm daim tawv nqaij erityahema, khaus, lossis mucosal congestion. Lub tshuab siv tau cuam tshuam nrog tsis cuam tshuam nrog tsis- kev sib txuas nrog cov khoom sib txuas, ua kom haum hlwb kom tso cov mob hlwb xws li histamine. Nqus tau hmoov nplej lossis aerosols tuaj yeem ua rau hnoos, ua pa nyuaj, lossis tus neeg caij nyoog. Cov kev sim tsiaj tau qhia tias qhov kev ua kom muaj kev puas tsuaj tau tuaj yeem ua rau alveolar epithelial hauv lub alveolar epitity thiab infiltration ntawm cov hlwb. Kev haus qhov ncauj yuav ua rau xeev siab, ntuav, tshwj xeeb, tshwj xeeb tshaj yog thaum nws txoj kev sib xyaw ua ke yuav kho kom me ntsis kev puas tsuaj rau lub plab zom mov. Ib qho ntxiv, cov seem ntawm DMOH cov kuab paug yuav ua rau muaj kev puas tsuaj rau kev puas tsuaj rau cov hnyuv mucosa.

Cov tshuaj lom ntev

Lub sij hawm ntev yuav ua rau lub siab enzymes (alt, antt), thiab nyob rau hauv cov neeg mob hnyav, daj ntseg ntawm daim siab ntawm lub siab Necrosis. Cov tebchaw tau yog metabolized nyob rau hauv daim siab dhau ntawm Cytochrome P450 enzyme system, thiab siab} Qhov muaj peev xwm tshaj lub peev xwm ntawm cov metabolites. Cov txheej txheem oxygen cov pa roj hmab (Ros) tsim tawm thaum cov ntxaij vab tshaus hauv daim raum hauv lub siab ntawm lub cev ntawm lub cell membrane. Cov tebchaw lossis lawv cov metabolites yuav khi rau cov protein ntawm daim siab ntawm cov protein uas lawv ua tiav etigens thiab kev ua tiav autoimmune tshua. Anim imiments tau qhia tias muaj ntev- Qhov kev mob hlwb lub siab, ua kom muaj cov zis ntau dua epithelial Cov txheej txheem yuav cuam tshuam nrog cov teebmeem kev lom zem ncaj qha lossis lawv cov metabolites ntawm lub raum roj ntsha thaum lawv nquag zais cia thiab tawm los ntawm lub raum tub. Muaj qee kis cov ntaub ntawv qhia tau hais tias ntev - Lub sijhawm ua rau mob taub hau, ua rau lub cev taub hau, los yog ua kom lub cev tsis sib xws los yog hnov ​​qab tsis zoo. Tsawg molecular hnyav compounds tej zaum yuav hla ntshav-}} bi} lub hlwb lub hlwb thiab cuam tshuam nrog neurotransmitter synthesis lossis tso tawm. Cov tebchaw yuav inhibit qhov kev ua si ntawm neuronal mitochondrial complexes, ua kom tsawg dua hauv ATP ntau lawm thiab ua cov neuronal apoptosis.

Kev tsis haum

Tus naj npawb me me ntawm cov tib neeg tuaj yeem tsim kho cov kev tsis haum tshuaj no Tus txheej txheem yog tias cov compound ua raws li ib qho antigen kom qhib lub ntshav ntshav, uas txawv rau ntawm cov tshuaj tiv thaiv kab mob ige. Thaum nthuav tawm ntxiv, nws ua rau qhov kev txiav txim siab ntawm Mast Cell thiab tso tawm rau cov mob kho mob kho mob xws li histamine. Ncua hom kev ua xua tuaj yeem pom tias yog hu rau dermatitis, feem ntau {- Cell kev tiv thaiv kab mob ntawm lub cev thiab ua rau T-Cell

Cov kev sib raug zoo hauv cov neeg tshwj xeeb

Cov kev sim tsiaj tau pom tias qhov siab {{0} Kev cuam tshuam txog kev sib txuas lus lossis cov mechanism muaj feem xyuam rau kev txhim kho embacations lossis me ntsis kev sib txuas lus tuaj yeem cuam tshuam nrog cov teeb meem ntawm cov embryonic los ntawm kev sib cuam tshuam ntawm cov kab mob ntawm kev sib kis placentalesis. Tom qab siv los ntawm lactating poj niam, tebchaw yuav tau txais zais los ntawm cov kua mis thiab muaj cov cuam tshuam rau cov menyuam mos. Cov menyuam yaus lub siab thiab lub raum ua haujlwm tsis tau tsim kho, thiab lawv cov metabolism tag nrho, uas yuav ua rau lawv muaj kev vam meej lossis kev sib deev tiav). Kev poob ntawm daim siab thiab lub raum ua haujlwm hauv cov neeg laus thiab txo qis hauv cov kev pheej hmoo ua si, tshwj xeeb yog kev pheej hmoo ntawm Hepatotoxicity thiab NeproToxicity.

 

Cim npe nrov: Fmoc - glu (obzl) {{} Oh {1} Oh-61-2, cov chaw tsim khoom, chaw tsim khoom, yuav khoom, loj, rau muag

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