MK-7 Intermediate(Melanotan II Intermediate) yog ib qho tseem ceeb ntawm cov tshuaj precursor nyob rau hauv cov txheej txheem tshuaj npaj ntawm peptide tshuaj Melanotan II (PT-141). Nws tsis yog cov tshuaj zaum kawg nrog kev ua haujlwm lom neeg ntawm nws tus kheej, tab sis yog lub tsev tshuaj lom neeg uas sawv cev rau lub hauv paus cyclic qauv ntawm cov tshuaj. Nws yuav tsum tau ua raws li cov txheej txheem hluavtaws tom ntej hauv chav kuaj kev tshaj lij kom hloov mus rau cov khoom tiav ntawm Melanotan II uas tuaj yeem siv rau kev tshawb fawb lossis kev kho mob. Qhov nruab nrab no tsuas yog ua raws li kev tshawb fawb tshawb fawb thiab kev tsim khoom lag luam. Yog tsis muaj kev pom zoo los ntawm lub koom haum tswj hwm tshuaj, nws yuav tsum tsis txhob siv ncaj qha rau tib neeg. Nws qhov kev yuav khoom, kev khaws cia, thiab kev siv yuav tsum ua raws li cov cai tswj xyuas cov tshuaj muaj feem xyuam.
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Tshuaj Formula |
C16H14O2 |
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Exact Mass |
238 |
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Molecular Luj |
238 |
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m/z |
238 (100.0%), 239 (17.3%), 240 (1.4%) |
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Elemental Analysis |
C, 80.65; H, 5.92; O, 13.43 |
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Ntau qhov chaw
MK-7 nruab nrabcomes from a wide range of sources, but the main sources are meat and natto.Vitamin K2 (MK-7) is mainly redistributed in the liver through low-density lipoprotein, which is rapidly cleared in the liver with the same lipoprotein as the carrier.Studies have shown that the side chain of vitamin K2 (MK-7) is longer than that of vitamin K2 (MK-4). Yog li ntawd, nws tuaj yeem nyob hauv tib neeg lub cev tau ntev, thiab nws cov bioavailability nyob rau hauv cov ntaub so ntswg extrahepatic yog siab dua.Kev siv tau zoo theem ntawm cov khoom tiav:1. Vitamin K2 (MK-7) belongs rau μ G / D qib (microgram level), ib hnub ib zaug, 90 micrograms txhua zaus;
2. Vitamin K2 (MK-4) belongs rau qib mg / D (mg theem), 15 mg peb zaug ib hnub twg (sib npaug rau 45000 micrograms ib hnub), thiab qhov xav tau ntau npaum li cas yog 500 npaug ntawm cov vitamin K2 (MK-7). Synthetic vitamin K2 (MK-7) tuaj yeem tau los ntawm natural extraction. Kev siv tseem ceeb ntawm cov khoom tiav: rau pob txha pob txha, txhim kho arterial calcification thiab kho tus kab mob Parkinson.Cov kev ua haujlwm ntawm cov vitamin K2 (MK-4) thiab vitamin K2 (MK-7) zoo ib yam, tab sis los ntawm kev sib piv ntawm cov ntaub ntawv sim ntawm cov khoom tiav, nws pom tau tias vitamin K2 (MK-7) yog deb tshaj ntawm cov ntsiab lus ntawm vitamin K2 (k2) biological kev ua ub no. kev ua tau zoo.
Melting point 42-45 ° C, Boiling point 109.7 ° C, ntom 1.25 (14% aq.), Refractive index n20 / D 1.378, Cia txias txias, Acidity coefficient (pKa) -4.06 ± 0. Incompatible nrog muaj zog oxidizing neeg sawv cev. , Hazardous mark C, N, T, Xn , Hazard qeb code 34-43-50-20 / 21 / 22-50 / 53-23 / 24 / 25-42 / 43 , Kev nyab xeeb cov lus qhia 26-36 / 37 / 39-45-60-23-23s , Kev nyab xeeb ntawm 26-36 / 37 / 39-45-60-27-23-s No.UN 1760 8 / PG 2 , WGK Lub Tebchaws Yelemees 1 , RTECS NX8156850 , HazardClass 8 , Packing Group III.
Peb yog cov chaw tsim khoom ntawm MPA.
Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog peb lub koom haum ntawm peb.
Muaj ob txoj hauv kev tseem ceeb rau kev sib txuasMK7 intermediates(MPA): ib qho yog muab rho tawm los ntawm tej yam ntuj tso, thiab lwm yam yog tau los ntawm cov tshuaj synthesis txoj kev.
MPA tuaj yeem muab rho tawm los ntawm cov nroj tsuag xws li rye thiab nplej.
MPA nyob rau hauv cov nroj tsuag no mas muaj nyob rau hauv nplooj thiab txiv hmab txiv ntoo. Cov txheej txheem extraction muaj xws li hnyav extraction, supercritical kua extraction, thiab lwm yam.
Ntawm lawv, cov txheej txheem tshem tawm hnyav siv cov kuab tshuaj xws li ethanol los rho cov nroj tsuag, thiab tom qab ntawd tau txais MPA los ntawm cov kauj ruam xws li crystallization thiab sib cais.
Txoj kev rho tawm cov kua dej supercritical siv cov kua dej xws li cov pa roj carbon dioxide supercritical raws li cov extractants, uas muaj qhov zoo ntawm tsis yog - lom thiab muaj kuab paug - dawb.
Kev rho tawm: Ua ntej, rho tawm MPA los ntawm cov khoom ntuj uas muaj MPA (xws li rye, nplej, thiab lwm yam). Extraction feem ntau siv cov kuab tshuaj organic xws li ethanol lossis ether. Thaum lub sij hawm extraction txheej txheem, lub cev dissolution tshwm sim, hloov MPA los ntawm tej yam ntuj tso tshuaj mus rau cov kuab tshuaj.
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Kev sib cais: Cov khoom sib xyaw ua ke tau dhau los ua cov kauj ruam sib cais kom cais cov kuab tshuaj thiab MPA. Cov kauj ruam no feem ntau yog siv txoj kev distillation lossis crystallization. Thaum lub sij hawm distillation txheej txheem, cov kuab tshuaj thiab MPA raug cais raws li lawv qhov sib txawv ntawm cov ntsiab lus boiling. Cov txheej txheem crystallization yog ua tiav los ntawm kev txo qhov kub ntawm qhov sib tov, ua rau MPA kom precipitate hauv crystalline daim ntawv.
Kev huv huv: Tom qab cov kauj ruam sib cais, MPA tau txais kuj tseem muaj lwm yam impurities. Txhawm rau txhim kho qhov purity ntawm MPA, purification yog tsim nyog. Kev lim dej tuaj yeem ua tiav los ntawm txoj kev xws li recrystallization thiab chromatographic sib cais. Recrystallization yog cov txheej txheem ntawm maj mam nce qhov purity ntawm MPA los ntawm kev rov ua dua crystallization. Chromatographic sib cais siv qhov sib txawv ntawm qhov sib txawv ntawm cov khoom sib txawv hauv cov theem nyob ruaj khov thiab cov xov tooj ntawm tes kom cais MPA los ntawm lwm yam khoom.
Architectural design & npaj cepteur sin occaecat cupidatat proident, tau txais kuv tus ntsuj plig tag nrho, zoo li no thaum sawv ntxov lub caij nplooj ntoos hlav qab zib uas kuv txaus siab nrog kuv tag nrho ... Architectural design & npaj cepteur sin occaecat cupidatat proident, tau txais los ntawm kuv tus ntsuj plig tag nrho, zoo li no thaum sawv ntxov qab zib ntawm lub caij nplooj ntoos hlav uas kuv txaus siab rau tag nrho lub caij nplooj ntoos hlav. consectetur adipisicing elit, sed ua eiusmod tempor incididunt labore thiab dolore magna aliqua. nws enim ad minim veniam.
Architectural design & npaj cepteur sin occaecat cupidatat proident, tau txais kuv tus ntsuj plig tag nrho, zoo li no thaum sawv ntxov lub caij nplooj ntoos hlav qab zib uas kuv txaus siab nrog kuv tag nrho ... Architectural design & npaj cepteur sin occaecat cupidatat proident, tau txais los ntawm kuv tus ntsuj plig tag nrho, zoo li no thaum sawv ntxov qab zib ntawm lub caij nplooj ntoos hlav uas kuv txaus siab rau tag nrho lub caij nplooj ntoos hlav. consectetur adipisicing elit, sed ua eiusmod tempor incididunt labore thiab dolore magna aliqua. nws enim ad minim veniam.
MK 7 Intermediate Application Siv
Synthetic vitamins
Lub hauv paus nruab nrab ntawm K2 MK-7 yog ib qho tseem ceeb hluavtaws substrate rau kev npaj ntawm vitamin K2 MK-7. Nrog nws cov qauv tshuaj tshwj xeeb, nws tuaj yeem ua kom muaj txiaj ntsig zoo ntawm MK-7 cov khoom lag luam los ntawm kev siv tshuaj lom neeg xws li ntxiv, cyclization, thiab purification. Nws yog ib qho tseem ceeb raw khoom rau industrial loj-scale zus tau tej cov no active tshuaj.
Khoom noj khoom haus thiab khoom noj khoom haus kev noj qab haus huv
Vitamin K2 MK-7 synthesized los ntawm qhov nruab nrab no feem ntau ntxiv rau cov pob txha thiab vascular noj qab haus huv.
Muaj peev xwm txhawb txoj kev tso nyiaj calcium zoo hauv cov pob txha, txhim kho pob txha toughness, thiab txo cov pob txha thiab pob qij txha poob hauv nruab nrab- cov neeg laus thiab cov neeg laus; Ib txhij tswj cov ntshav lipid metabolism hauv lub cev, pab tswj vascular elasticity thiab kev noj qab haus huv.
Daim ntawv thov hauv kev tshawb fawb tshuaj thiab kev txhim kho
Yuav siv tau rau kev tshawb fawb thiab kev loj hlob ntawm cov tshuaj orthopedic thiab mob plawv.
Raws li cov tshuaj pharmacological ntawm nws cov khoom siv hluavtaws, nws koom nrog hauv kev tswj cov txheej txheem coagulation ntawm lub cev, tswj kev thauj thiab cov metabolism hauv calcium hauv lub cev, thiab muab cov khoom siv tseem ceeb rau kev tsim cov tshuaj nquag thiab kev sim tshuaj rau cov kab mob ntsig txog.
Khoom noj thiab tsiaj pub
Cov khoom xyaw nquag tau los ntawm kev sib sib zog nqus ntawm cov khoom noj khoom haus ntxiv tuaj yeem siv los ua cov khoom noj khoom haus, ntxiv rau cov khoom siv mis nyuj, hloov zaub mov.
Thiab cov khoom noj txom ncauj ua haujlwm ntxiv rau kev noj haus txhua hnub; Nws tseem tuaj yeem muab sib xyaw rau hauv cov tsiaj yug tsiaj los txhawb kev loj hlob ib txwm thiab kev loj hlob ntawm cov pob txha tsiaj, txhim kho nqaij zoo thiab yug me nyuam zoo.
Fine chemical derivative khoom
Cov molecules npaj muaj tshuaj zoo reactivity thiab muaj peev xwm koom nyob rau hauv ntau yam organic synthesis cov tshuaj tiv thaiv kom tau zoo tshuaj sib txuas xws li terpenes thiab lipids. Lawv tau dav haum rau kev tshawb fawb thiab tsim cov xwm txheej ntawm cov khoom siv tshuaj pleev ib ce niaj hnub, kev npaj bioactive, thiab lwm yam khoom.
chemical fabrication
(1) Dissolution: MPA nyob rau hauv tej yam ntuj tso tshuaj (xws li rye) yog yaj nyob rau hauv cov kuab tshuaj xws li ethanol los yog ether. Cov txheej txheem kev sib cais tuaj yeem qhia tau hais tias: MK-7+Solvent → MK-7 Solvent
(2) Kev sib cais: Cov kuab tshuaj thiab MPA sib cais los ntawm txoj kev xws li distillation lossis crystallization. Cov qauv tshuaj tiv thaiv rau cov txheej txheem distillation tuaj yeem qhia tau hais tias: Solvent + Kub → Vapor Solvent, thiab cov qauv tshuaj tiv thaiv rau cov txheej txheem crystallization tuaj yeem qhia tau hais tias: MK-7 Solvent + Kub → MK-7 Crystal + Liquid Solvent
(3) Purification: cais MPA los ntawm lwm yam impurities los ntawm txoj kev xws li recrystallization lossis chromatographic sib cais. Cov qauv tshuaj tiv thaiv rau cov txheej txheem recrystallization tuaj yeem qhia tau tias MK-7 Crystal + Kub → MK-7 Crystal, thiab cov qauv tshuaj tiv thaiv rau cov txheej txheem chromatographic sib cais tuaj yeem qhia tau tias yog MK-7+Mobile Phase → MK-7 Mobile Phase + Stationary Phase
chemical compositing
Tshuaj synthesis yog lwm txoj hauv kev kom tau txais MPA. Txoj kev no feem ntau yog siv pentadiene ua cov khoom siv raw thiab ua tiav cov txheej txheem tshuaj tiv thaiv kom tau MPA. Txoj kev tshwj xeeb synthesis yog raws li nram no:
(1) 3-Chloro-1,2-pentadiene tau txais los ntawm pentadiene los ntawm cov txheej txheem tshuaj tiv thaiv xws li chlorination thiab dehydrochlorination.
(2) React 3-chloro-1,2-pentadiene nrog alkali kom tau 3-chloro-1,2-pentanediol.
(3) Hydrogenation txo ntawm 3-chloro-1,2-pentanediol yields 3-hydroxy-1,2-pentanediol.
(4) Oxidize 3-hydroxy-1,2-pentanediol kom tau 3-oxo-1,2-pentanediol.
(5) Dehydrogenate 3-oxo-1,2-pentanediol kom tau MPA.
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Cov tshuaj tiv thaiv oxidation: Cov tau txais 3-hydroxy-1,2-pentanediol raug oxidation cov tshuaj tiv thaiv nyob rau hauv qhov kev txiav txim ntawm oxidant kom tau 3-oxo-1,2-pentanediol. Oxidants tuaj yeem xaiv los ntawm nitric acid, chromic acid, thiab lwm yam.
CH2OHCH2CHOJ2OH + OX → CH2OHCOHOHCH2OH
Dehydrogenation cov tshuaj tiv thaiv: Cov tau txais 3-oxo-1,2-pentanediol yog dehydrogenated nrog hydrogen gas nyob rau hauv tej yam kub thiab siab tej yam kev mob nyob rau hauv qhov kev txiav txim ntawm ib tug catalyst kom tau.MK-7 Intermediate. Catalysts tuaj yeem xaiv cov hlau catalysts, xws li npib tsib xee, palladium, thiab lwm yam.
CH2OHCOHOHCH2OH + H2→ CH3CH=CHOJ
Cov Lus Qhia Txog Kev Nyab Xeeb
Ua raws li kev noj haus pom zoo
Rau kev ntxiv cov vitamin K2 (MK-7), cov kev pom zoo kom noj ntau los ntawm cov tsev kawm ntawv nto moo hauv ntiaj teb lossis cov chaw tshaj lij yuav tsum ua raws. Txawm hais tias qhov kev pom zoo tam sim no rau cov menyuam yaus yog 45-50 micrograms ib hnub (MK-7 daim ntawv), qhov tshwj xeeb pom zoo noj rau cov neeg laus thiab cov neeg tshwj xeeb yuav txawv.
Saib xyuas kev noj qab haus huv
Thaum lub sij hawm ntxiv ntawm vitamin K2 (MK-7), ib tug yuav tsum tau saib xyuas lawv cov kev noj qab haus huv. Yog tias muaj kev tsis xis nyob lossis xav tias muaj kev phiv tshwm sim, kev noj tshuaj ntxiv yuav tsum raug tso tseg tam sim ntawd thiab yuav tsum tau sab laj nrog kws kho mob.
Xaiv lub hom lag luam txhim khu kev qha
Thaum yuav cov tshuaj vitamin K2 (MK-7), nws raug nquahu kom xaiv cov khoom lag luam los ntawm cov khoom lag luam txhim khu kev qha thiab cov neeg muag khoom kom ntseeg tau lawv qhov zoo thiab kev nyab xeeb.
Ua tib zoo saib xyuas qhov sib txawv ntawm tus kheej
Tus kheej rhiab heev thiab kev thov rau vitamin K2 yuav txawv. Yog li ntawd, nws raug nquahu kom sab laj nrog kws kho mob lossis kws kho mob noj zaub mov ua ntej ntxiv, tshwj xeeb tshaj yog rau cov tib neeg uas muaj mob tshwj xeeb lossis cov uas noj lwm yam tshuaj.
FAQ
1. MK7 Intermediate yog dab tsi?
MK 7 Intermediate yog ib qho tseem ceeb nruab nrab ntawm cov txheej txheem tshuaj synthesis ntawm cov tshuaj peptide hluavtaws melanotan II (tseem hu ua PT-141 lossis cov metabolite nquag ntawm Bremelanotide). Nws tsis yog qhov kawg ua tiav cov tshuaj nws tus kheej, tab sis nws yog ib qho tsim nyog tshuaj precursor los yog lub tsev thaiv rau zus tau tej cov melanotan II. Nws lub npe tshuaj feem ntau yog Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH los yog cov qauv zoo sib xws, sawv cev rau lub hauv paus cyclic qauv ntawm melanotan II.
2. Lub luag haujlwm ntawm MK 7 Intermediate yog dab tsi?
Raws li cov tshuaj nruab nrab, lub ntsiab "kev ua haujlwm" ntawm MK 7 Intermediate yog siv rau hauv kev tshawb fawb hauv chav kuaj thiab loj- nplai ntau lawm ntawm melanotan II. Cov kws tshawb fawb thiab cov kws tsim tshuaj siv tau hloov nws los ntawm cov tshuaj tiv thaiv tom ntej mus rau hauv cov khoom lag luam bioactive melanotan II. Nws tsis yog siv rau tib neeg noj thiab tsis muaj qhov cuam tshuam ntawm lub cev tau tshaj tawm rau melanotan II, xws li pab txhawb kev sib deev los yog kho kev sib deev dysfunction.
3. Puas yog MK- 7 Nruab nrab siv tau rau tib neeg?
Tsis yog kiag li. MK- 7 Intermediate yog cov khoom siv tshuaj lom neeg nkaus xwb rau kev tshawb fawb. Nws tsis tau dhau los ua kev ua kom huv, kev nyab xeeb thiab kev ua tau zoo los ntawm ib lub koom haum tswj hwm tshuaj (xws li FDA, EMA), thiab tej zaum yuav muaj cov impurities tsis paub lossis cov kuab tshuaj seem, ua rau muaj kev pheej hmoo rau tib neeg kev noj qab haus huv. Txhua yam kev muag, txhawb lossis siv nws ua cov khoom peptide tiav rau tib neeg yog txhaum cai thiab txaus ntshai.
4. Dab tsi yuav tsum tau sau tseg thaum yuav MK -7 Intermediate?
Yog tias koj yog tus neeg sawv cev ntawm kev yuav khoom los ntawm lub chaw tshawb fawb raws li kev tshawb fawb los yog lub chaw soj nstuam, koj yuav tsum xyuas kom meej: Lub hom phiaj meej: Nws tsuas yog siv rau kev tshawb fawb txog kev tshawb fawb los yog kev tsim khoom, thiab tsis yog rau tib neeg siv. Cov khoom tsim nyog: Tau txais los ntawm cov neeg muag khoom muaj npe uas tuaj yeem muab cov ncauj lus kom ntxaws txog kev nyab xeeb cov ntaub ntawv (MSDS) thiab cov ntaub ntawv pov thawj kev cai purity. ntawm lub teb chaws / cheeb tsam hais txog kev yuav khoom, khaws cia, thiab siv tshuaj. Cov neeg siv khoom ib txwm tsis yog thiab tsis tuaj yeem raug cai yuav cov khoom nruab nrab no.
Cim npe nrov: mk-7 intermediate cas 97804-50-7, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom