Kisspeptin-10 peptideyog ib yam khoom peptide nrog ntau yam kev ua ub no, tshwj xeeb tshaj yog nrog kev tshawb fawb muaj txiaj ntsig hauv thaj chaw ntawm biology thiab tshuaj. Cov mis mos molecular feem ntau yog C63H83N17O15 (rau cov chaw nas) lossis C63H83N17O14 (rau tib neeg qhov chaw), CAS 374675-21-5. Rau cov chaw nas, nws qhov hnyav molecular yog kwv yees li 1318.44; Rau tib neeg qhov chaw, qhov hnyav molecular yog kwv yees li 1302.44. Nws muaj peev xwm tswj tau qhov excitability thiab synaptic kis tau tus mob ntawm neurons, thiab koom nyob rau hauv tsim thiab txij nkawm ntawm neural circuits. Kev faib tawm thoob plaws hauv lub hlwb, nws cuam tshuam nrog ntau yam neurotransmitters thiab neuromodulators koom ua ke tswj kev ua haujlwm ntawm lub paj hlwb. Nws kuj muaj peev xwm thov kev kho mob tus nqi. Vim nws lub luag haujlwm tseem ceeb hauv kev ua me nyuam thiab lub paj hlwb, nws tuaj yeem dhau los ua tus neeg sib tw rau cov tshuaj tshiab los kho qee cov kab mob ntsig txog kev ua me nyuam thiab lub paj hlwb. Piv txwv li, nyob rau hauv lub teb ntawm cov kab mob ntawm cov me nyuam, nws yuav siv tau los kho cov teeb meem xws li kev sib deev dysfunction thiab infertility. Hauv thaj chaw ntawm cov kab mob neurological, nws tuaj yeem siv los tswj cov excitability ntawm neurons, kho cov kab mob neurodegenerative, kev nyuaj siab, thiab lwm yam.
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Customized Bottle Caps Thiab Corks:
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Tshuaj Formula |
C63H83N17O14 |
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Exact Mass |
1302 |
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Molecular Luj |
1302 |
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m/z |
1302 (100.0%), 1303 (68.1%), 1304 (22.8%), 1303 (5.9%), 1305 (5.0%), 1304 (4.3%), 1304 (2.9%), 1305 (2.0%), 1305 (1.3%) |
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Elemental Analysis |
C, 58.10; H, 6.42; N, 18.28; O, 17.20 |
Kisspeptin-10 peptideyog ib yam khoom tseem ceeb peptide uas ua haujlwm ntau yam hauv cov kab mob, tshwj xeeb tshaj yog nyob rau hauv cov me nyuam thiab cov hlab ntsha. Los ntawm kev cuam tshuam nrog GPR54 receptor, nws koom nrog kev tswj hwm ntau yam txheej txheem physiological, suav nrog kev loj hlob ntawm kev laus, kev loj hlob, kev sib deev, kev sib deev, lub zog metabolism, thiab neuronal excitability thiab synaptic kis tau tus mob.
Ua ntej, nws muaj cov haujlwm tseem ceeb hauv kev ua me nyuam. Nws yog lub ntuj ligand ntawm GPR54 receptor uas tswj kev tso tawm ntawm gonadotropin- tso cov tshuaj hormone (GnRH) los ntawm kev ua kom lub receptor. GnRH yog ib qho tseem ceeb hauv kev tswj hwm cov tshuaj hormone secretion raws li kev ua me nyuam axis, thiab tseem ceeb heev rau kev tswj cov tub ntxhais hluas txoj kev loj hlob thiab lub voj voog kev loj hlob. Kev khi rau GPR54 receptor tuaj yeem txhawb kev ua haujlwm ntawm GnRH neurons, yog li txhawb kev tso tawm ntawm GnRH. Txoj haujlwm no ua lub luag haujlwm tseem ceeb hauv kev tswj cov kev ua menyuam yaus thiab tseem ceeb heev rau kev noj qab haus huv ntawm cov menyuam yaus.
nws kuj ua lub luag haujlwm tseem ceeb hauv lub paj hlwb.
Qhov thib ob, nws kuj ua lub luag haujlwm tseem ceeb hauv lub paj hlwb. Nws yog dav faib nyob rau hauv ntau thaj tsam ntawm lub hlwb thiab cuam tshuam nrog ntau yam neurotransmitters thiab neuromodulators. Nws muaj peev xwm tswj tau qhov excitability thiab synaptic kis tau tus mob ntawm neurons, thiab koom nyob rau hauv tsim thiab txij nkawm ntawm neural circuits. Kev tshawb fawb tau pom tias nws ua lub luag haujlwm tseem ceeb hauv kev tswj tus cwj pwm kev sib deev, kev xav hauv siab, thiab kev paub txog kev ua haujlwm. Los ntawm kev cuam tshuam cov kev ua ntawm neurons thiab synaptic kis tau tus mob efficiency, nws muaj peev xwm tswj tau lub functionality ntawm lub paj hlwb, yog li cuam tshuam rau tus kheej tus cwj pwm thiab lub siab lub ntsws lub xeev.
Tsis tas li ntawd, nws kuj muaj kev ua haujlwm ntawm kev tswj lub zog metabolism. Nws tuaj yeem cuam tshuam kev qab los noj mov thiab lub zog sib npaug, koom nrog tswj cov roj metabolism thiab cov piam thaj homeostasis. Los ntawm kev cuam tshuam lub qab los noj mov kev cai chaw nyob rau hauv lub hypothalamus, nws tswj noj tus cwj pwm thiab lub zog siv. Qhov kev ua haujlwm no ua rau nws muaj peev xwm los kho cov rog rog thiab cov kab mob metabolic. Los ntawm kev tswj hwm nws cov haujlwm, nws tuaj yeem pab txhim kho tus neeg lub zog metabolism, tiv thaiv thiab kho cov kab mob cuam tshuam.
nws kuj tseem yuav muaj lwm yam kev ua ub no lom neeg
Ntxiv nrog rau cov haujlwm saum toj no, nws kuj tseem tuaj yeem muaj lwm yam kev ua haujlwm lom neeg. Piv txwv li, qee qhov kev tshawb fawb qhia tias nws tuaj yeem koom nrog hauv kev tswj hwm lub cev tiv thaiv kab mob, kev ua haujlwm ntawm lub plawv, thiab kev txhim kho neoplasm. Kev tshawb pom ntawm cov haujlwm no muab kev muaj peev xwm rau lawv daim ntawv thov hauv ntau qhov chaw thiab tseem muab cov lus qhia tshiab rau lawv cov kev tshawb fawb hauv kev kho mob.
Hais txog kev siv tshuaj kho mob, kev tshawb fawb muaj kev cia siab dav. Ua ntej, nyob rau hauv kev ua liaj ua teb cov tshuaj, nws muaj peev xwm ua hauj lwm raws li ib tug muaj peev xwm siv tshuaj rau kev kho cov kab mob xws li kev sib deev dysfunction thiab infertility. Los ntawm kev tswj hwm nws cov haujlwm, nws tuaj yeem txhawb nqa kev tso tawm ntawm GnRH, yog li txhim kho kev ua haujlwm ntawm cov menyuam yaus. Thib ob, nyob rau hauv thaj tsam ntawm kev puas siab puas ntsws thiab kev puas siab puas ntsws, nws tuaj yeem siv los kho cov kev xav tsis zoo xws li kev nyuaj siab thiab kev ntxhov siab, nrog rau kev paub tsis meej thiab lwm yam kab mob. Los ntawm kev tswj hwm lub xeev kev ua haujlwm ntawm lub paj hlwb, nws tuaj yeem pab txhim kho tus neeg lub siab lub ntsws thiab kev coj cwj pwm. Tsis tas li ntawd, nws kuj tseem tuaj yeem dhau los ua tus neeg siv tshuaj tshiab los kho cov rog rog thiab cov kab mob metabolic, txhim kho tus neeg noj qab haus huv los ntawm kev tswj hwm lub zog metabolism.
Metastin (45-54), raws li cov tshuaj peptide, muaj cov yam ntxwv tshwj xeeb hauv kev ua liaj ua teb thiab tshuaj. Cov hauv qab no yog ob peb yam tseem ceeb:
Nws yog ib qho zoo endogenous GPR54 agonist. GPR54, tseem hu ua KISS1 receptor, yog G protein ua ke receptor. Metastin (45-54) ua lub luag haujlwm tseem ceeb hauv kev tswj hwm cov tshuaj hormone secretion raws li kev ua me nyuam axis los ntawm kev khi rau GPR54 thiab ua kom nws txoj hauv kev qis qis. Cov yam ntxwv no ua rau cov tshuaj metastin (45-54) ua lub luag haujlwm tseem ceeb hauv ntau yam xws li kev loj hlob ntawm cov tub ntxhais hluas, lub voj voog kev loj hlob, thiab kev sib deev tus cwj pwm.
Nws tseem ua lub luag haujlwm tseem ceeb hauv lub zog metabolism thiab lub paj hlwb. Nws tuaj yeem cuam tshuam kev qab los noj mov thiab lub zog sib npaug, koom nrog tswj cov roj metabolism thiab cov piam thaj homeostasis. Lub caij no, metastin (45-54) yog dav faib nyob rau hauv lub hlwb thiab cuam tshuam nrog ntau yam neurotransmitters thiab neuromodulators koom ua ke tswj kev ua haujlwm ntawm lub paj hlwb. Cov haujlwm no ua rau cov tshuaj metastin (45-54) muaj peev xwm siv tau hauv kev kho mob rog rog, metabolic ntshawv siab, thiab mob hlwb thiab puas hlwb.
Nws muaj ob txoj haujlwm, ua haujlwm raws li vasoconstrictor thiab inhibitor ntawm angiogenesis. Qhov no feature muaj peev xwm siv tus nqi nyob rau hauv lub plawv system. Kev tswj hwm vascular nro thiab angiogenesis tuaj yeem yog qhov tseem ceeb rau kev kho thiab tiv thaiv kab mob plawv.
Qhia cov teebmeem tshwj xeeb hauv neoplasm metastasis inhibition. Kev tshawb fawb tau pom tias nws ua raws li neoplasm metastasis suppressor los ntawm nws cov receptor GPR54. Kev ua kom muaj peev xwm inhibit tib neeg lub ntsws melanoma, thiab nws kuj tau lees paub tias yog tus kabmob metastasis hauv cov qog nqaij hlav cancer mis. Cov kev tshawb pom no muaj peev xwm ua tau rau lawv daim ntawv thov hauv kev kho neoplasm.
Kisspeptin-10 peptide, raws li ib tug luv luv peptide molecule nrog ntau yam kev ua ub no lom neeg, feem ntau yog ua los ntawm tshwj xeeb khi rau nws tshwj xeeb receptor GPR54 (tseem hu ua KISS1R) ua rau ib tug series ntawm complex intracellular teeb liab transduction txheej txheem, yog li exerting ntau yam tseem ceeb lom functions. Nws plays lub luag haujlwm tseem ceeb hauv ntau lub cev lub cev thiab cov txheej txheem pathological ntawm lub cev.
Nyob rau hauv cov nqe lus ntawm kev tswj cov kev ua me nyuam, activating GPR54 receptors ua ib tug tseem ceeb txoj cai rau kev tswj cov tshuaj hormones secretion nyob rau hauv cov me nyuam axis. Cov kev cai tswjfwm no muaj qhov cuam tshuam loj thiab muaj txiaj ntsig zoo rau cov txheej txheem physiological ntawm lub cev, suav nrog ntau theem tseem ceeb los ntawm kev loj hlob ntawm kev laus, kev saib xyuas ntawm lub voj voog kev loj hlob tsis tu ncua, mus rau qhov kev coj ua ntawm kev sib deev. Tshwj xeeb tshaj yog, thaum nws khi rau GPR54 receptor, nws tuaj yeem ua kom lub zog hypothalamus kom zais gonadotropin- tso tawm cov tshuaj hormones (GnRH). GnRH, raws li ib tug tseem ceeb neurohormone, ntxiv ua rau lub anterior pituitary caj pas, txhawb nws secretion ntawm follicle stimulating hormone (FSH) thiab luteinizing hormone (LH).
Cov gonadotropins no ces mus txog gonads (ovaries lossis testes) los ntawm cov ntshav ncig, tswj cov synthesis thiab secretion ntawm gonadotropins, yog li ua tiav cov kev cai ntawm kev ua me nyuam ua haujlwm. Piv txwv li, thaum lub sij hawm puberty, ib qho kev nce nyob rau hauv nws cov theem ua rau ib tug series ntawm reproductive endocrine hloov, txhawb lub maturation ntawm kev sib deev kab mob thiab tshwm sim ntawm lwm yam kev sib deev yam ntxwv; Thaum lub sij hawm lub voj voog kev ua me nyuam, nws koom nrog hauv kev tswj lub cev lub cev thiab cov txheej txheem ntawm ovulation, ua kom muaj kev ua haujlwm ntawm kev ua me nyuam; Nyob rau hauv cov nqe lus ntawm kev sib deev cwj pwm, nws kuj indirectly tswj libido thiab kev sib deev kev ua tau zoo los ntawm kev cuam tshuam cov tshuaj hormones kev sib deev.
Nws tseem ua lub luag haujlwm tseem ceeb hauv kev tsim cov embryonic ob lub raum. Kev tshawb fawb tau pom tias metastin (45-54)-10-GPR54 system plays lub luag haujlwm tseem ceeb hauv ntau theem tseem ceeb ntawm kev loj hlob ntawm embryonic raum, thiab tseem ceeb heev rau lub cev morphogenesis thiab kev loj hlob ntawm lub raum. Nyob rau hauv cov theem thaum ntxov ntawm embryonic txoj kev loj hlob, cov kab ke no koom nrog hauv kev tsim thiab kev sib txawv ntawm lub raum primordia, coj txoj kev tsiv teb tsaws thiab kev sib sau ua ke ntawm cov hlwb ua ntej ntawm nephrons, kom ntseeg tau qhov tsim nyog ntawm cov qauv ntawm lub raum.
Raws li lub embryo txhim kho, nws tswj kev tsim thiab kev loj hlob ntawm lub raum cov hlab ntsha los ntawm kev khi rau GPR54 receptors, muab cov ntshav txaus rau lub raum kom ua tau raws li lawv cov kev xav tau metabolic. Tsis tas li ntawd, nws tseem koom nrog kev tswj hwm kev loj hlob, kev sib txawv, thiab apoptosis ntawm lub raum hlwb, tswj kom muaj nuj nqis thiab ua haujlwm ntawm lub raum hlwb, yog li ua kom lub raum ua haujlwm tseem ceeb xws li kev tso tawm, kev sib npaug ntawm cov kua dej, thiab kev tswj hwm endocrine. Yog tias muaj qhov txawv txav hauv metastin (45-54)-10-GPR54 system thaum lub sij hawm embryonic raum kev loj hlob, nws yuav ua rau lub raum loj hlob txawv txav los yog kev ua haujlwm tsis zoo, ua rau muaj kab mob hauv lub raum.
Nws kuj tseem muaj qhov tseem ceeb los tiv thaiv- qog nqaij hlav metastasis, uas tau nyiam ntau yam hauv kev tshawb fawb neoplasm. Neoplasm metastasis yog ib qho tseem ceeb ntawm kev tuag hauv malignant neoplasms, thiabkisspeptin-10 peptidetuaj yeem cuam tshuam cov metastasis thiab kis ntawm neoplasm hlwb los ntawm ntau qhov txuas los ntawm kev ua kom GPR54 receptor. Ntawm qhov tod tes, nws tuaj yeem ua ncaj qha rau ntawm cov hlwb neoplasm, tswj cov kev taw qhia txog kev tsiv teb tsaws thiab kev cuam tshuam hauv cov hlwb neoplasm, inhibiting lawv motility thiab secretion ntawm matrix degrading enzymes, yog li txo lawv lub peev xwm nkag mus rau hauv qab daus daim nyias nyias thiab vascular phab ntsa, thiab tiv thaiv lawv los ntawm kev nkag mus rau hauv cov hlab ntsha thiab lymphatic system nyob deb metastasis.
Ntawm qhov tod tes, nws tseem tuaj yeem tswj hwm qhov neoplasm microenvironment, cuam tshuam rau kev ua haujlwm thiab kev ua haujlwm ntawm neoplasm txuam nrog fibroblasts, lub cev tiv thaiv kab mob, thiab lwm yam stromal hlwb, inhibit neoplasm angiogenesis, thiab txiav tawm cov khoom noj khoom haus thiab metastasis channel ntawm neoplasm hlwb. Raws li cov txheej txheem tiv thaiv - qog metastasis no, lawv tau dhau los ua lub hom phiaj rau kev kho mob qog noj ntshav, muab cov tswv yim tshiab thiab cov lus qhia rau kev txhim kho cov tshuaj tiv thaiv kab mob tshiab. Tam sim no, ntau cov kev tshawb fawb tau mob siab rau tshawb nrhiav yuav ua li cas siv cov tshuaj no los yog nws cov analogues los inhibit neoplasm metastasis, txhim kho cov ciaj sia taus thiab lub neej zoo ntawm cov neeg mob qog noj ntshav.
Nws kuj yog ib qho zoo vasoconstrictor thiab angiogenesis inhibitor, ua lub luag haujlwm tseem ceeb hauv cov hlab plawv. Nyob rau hauv cov nqe lus ntawm vascular tone tswj, los ntawm kev khi rau GPR54 receptor ntawm vascular du leeg hlwb, lub intracellular teeb liab transduction txoj kev yog qhib, ua rau vascular du nqaij contraction thiab txo vascular txoj kab uas hla, yog li ua rau vascular tsis kam thiab nce ntshav siab. Cov nyhuv vasoconstrictive no tseem ceeb heev hauv lub cev cov lus teb rau kev ntxhov siab ntawm lub cev (xws li kev tawm dag zog, nro, thiab lwm yam), vim nws tuaj yeem pab lub cev kho cov ntshav sai thiab ua tau raws li cov ntshav xav tau ntawm lub cev tseem ceeb. Txawm li cas los xij, hauv qee yam kab mob, xws li ntshav siab, overexpression lossis nce kev ua haujlwm tuaj yeem ua rau vasoconstriction ntau dhau, ua rau cov ntshav siab nce siab thiab koom nrog qhov tshwm sim thiab kev loj hlob ntawm cov ntshav siab.
Nyob rau hauv cov nqe lus ntawm regulating angiogenesis, inhibition ntawm angiogenesis yog ua tiav los ntawm suppressing proliferation, migration, thiab lumen tsim ntawm endothelial hlwb. Angiogenesis yog tsim nyog nyob rau hauv ntau yam physiological txheej txheem (xws li lub qhov txhab kho, embryonic txoj kev loj hlob, thiab lwm yam), tab sis nyob rau hauv neoplasm kev loj hlob thiab ib co qhov muag kab mob (xws li ntshav qab zib retinopathy), txawv txav angiogenesis yuav txhawb cov kab mob. Yog li, cov nyhuv inhibitory ntawm angiogenesis ua rau nws muaj txiaj ntsig zoo rau kev kho thiab tiv thaiv kab mob plawv. Piv txwv li, los ntawm kev tswj hwm qib lossis kev ua haujlwm ntawm metastin (45-54), nws tuaj yeem pab tswj cov ntshav txaus rau neoplasms thiab inhibit qhov kev loj hlob ntawm neoplasm; Hauv kev kho mob ntawm qhov muag kab mob, nws yuav pab tau inhibit qhov tsim ntawm neovascularization txawv txav thiab tiv thaiv qhov muag pom.
FAQ
Cov txiaj ntsig ntawm metastin (45-54) peptide yog dab tsi?
Kisspeptin peptide cov txiaj ntsig chaw ntawm nws lub luag haujlwm ua tus tswj hwm cov tshuaj hormones, feem ntau boosting kev noj qab haus huv ntawm cov me nyuam los ntawm stimulating natural testosterone thiab estrogen ntau lawm, txhim kho libido, txhim kho fertility nyob rau hauv tej yam kev mob xws li PCOS, thiab pab ovulation nyob rau hauv IVF. Nws kuj qhia tau hais tias kev cog lus hauv kev txhim kho lub siab, lub zog, cov metabolism, thiab muaj peev xwm txo tau cov qog, muab kev nyab xeeb dua rau qee cov tshuaj fertility los ntawm kev ua haujlwm nrog lub cev hormonal txoj hauv kev.
Puas yog kisspeptin-10 peptide ua kom cov leeg loj hlob?
Los ntawm kev nce qib LH thiab FSH, kisspeptin thiab nws cov agonists tuaj yeem txhawb nqa testosterone ntau lawm, tshwj xeeb tshaj yog cov txiv neej. Testosterone yog ib qho zoo -paub anabolic steroid uasua kom cov leeg nqaij, muaj zog, thiab rov qab los, muab qhov muaj txiaj ntsig zoo hauv kev ua kis las (doping).
Dab tsi peptide zoo tshaj rau testosterone?
Ob tug peptides no yogkisspeptin-10 thiab gonadorelin. Hauv ib txoj kev tshawb fawb, kisspeptin-10 nce qhov nruab nrab ntawm cov tshuaj testosterone qib hauv 24 teev ntawm kev txhaj tshuaj.
Dab tsi yog qhov tsis muaj . 1 testosterone booster?
Tsis muaj ib qho "tus naj npawb 1" testosterone booster, tab sis kev tshawb fawb qhia txog cov khoom xyaw xws li Ashwagandha, Tongkat Ali, Fenugreek, Magnesium, thiab Vitamin D rau cov txiaj ntsig zoo, nrog Ashwagandha feem ntau hais txog kev txo cov kev ntxhov siab thiab txhawb nqa testosterone hauv qee tus txiv neej, thiab Tongkat Ali rau qaug zog. Kev hloov hauv kev ua neej, tshwj xeeb tshaj yog kev tawm dag zog (qhov hnyav) thiab kev noj zaub mov noj qab haus huv, tau raug pov thawj tias muaj kev cuam tshuam ntau dua ntawm cov qib testosterone ntau dua li cov tshuaj ntxiv. Nco ntsoov sab laj nrog kws kho mob ua ntej pib cov tshuaj ntxiv.
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