Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm melanostatin dm hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo melanostatin dm rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Melanostatin DMyog ib qho tshuaj lom neeg sib xyaw ua ke hexapeptide, tshwm sim dawb los yog tawm - cov hmoov dawb nrog cov dej zoo solubility. Raws li lub ntiaj teb cov khoom lag luam raw khoom sib koom ua ke hauv cov tshuaj zoo thiab peptide synthesis, Bloomtechz muaj nws tus kheej peptide synthesis ntau lawm puag. Lawv tau teeb tsa lawv tus kheej cov khoom siv -theem peptide synthesis kab thiab tsim cov txheej txheem tsim khoom rau cov khoom no, tso cai rau kev tswj hwm tag nrho los ntawm amino acid monomer pub, khoom-theem synthesis, cleavage, purification, lyophilization, kev soj ntsuam zoo, rau ntim. Qhov no zam qhov kev pheej hmoo ntawm kev hloov pauv zoo los ntawm kev yuav khoom nruab nrab, thiab lawv lub peev xwm tsim tau yooj yim thiab kho tau.
Peb Cov Khoom Muag Khoom
Melanostatin DMCOA
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| Certificate of Analysis | ||
| Compound npe | histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide/Melanostatin DM | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 123689-72-5 | |
| Ntau | 18g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090057 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |  |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.59% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.64% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.75% |
| Ib qho impurity | <0.8% | 0.75% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 200 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Chemical Formula: | C41H58N14O6 |
| Exact Mass: | 842.47 |
| Molecular Luj: | 843.01 |
| m/z: | 842.47 (100.0%), 843.47 (44.3%), 844.47 (9.6%), 843.46 (5.2%), 844.47 (2.3%), 844.47 (1.2%) |
| Elemental Analysis: | C, 58.42; H, 6.94; N, 23.26; O, 11.39 |
Bloomtechz, raws li cov khoom lag luam thoob ntiaj teb tau tsom mus rau qib siab -kawg- theem peptide synthesis, tsis yog lo rau cov kev kawm raws li kev kawm. Los ntawm ntau qhov kev txiav- ntug kev tshawb fawb pom uas tsis tshua muaj kev sib tham hauv kev lag luam, nws piav qhia txog yuav ua li casmelanostatin DMtuaj yeem ua kom pom ntau hom pob thiab txhim kho cov tawv nqaij tsis sib xws. Qhov no muab cov qauv tshuaj pleev ib ce, hom R & D cov chaw, thiab cov chaw tshawb fawb nrog cov kev pom tshwj xeeb rau cov khoom xyaw, cov tswv yim rau kev tsim qauv, thiab cov tswv yim rau kev muag khoom lag luam.
Intervening nyob rau hauv kev sib txuas lus network ntawm epidermal hlwb
Melanocytes lawv tus kheej tsis tso tawm ntau ntawm -MSH ntawm lawv tus kheej. Lub precursor POMC ntawm -MSH feem ntau yog los ntawm ib puag ncig keratinocytes. Pigmentation yog qhov tseem ceeb ntawm homeostatic imbalance ntawm paracrine signals ntawm epidermal hlwb, tsis yog ib qho kev ywj pheej "lesion" ntawm melanocytes. Thaum daim tawv nqaij raug UVB irradiation, me me raug mob, los yog inflammatory stimulation, keratinocyte DNA puas, activating POMC noob transcription, uas txiav mus rau hauv polypeptide signaling molecules xws li -MSH thiab -endorphin, uas yog tso rau hauv lub epidermal cell chaw ntawm paracrine channels.
Lawv khi rau MC1R receptors ntawm melanocyte membrane thiab pib cAMP-PKA-CREB-MITF cascade, upregulating proteins uas cuam tshuam rau melanocyte synthesis. Hauv lwm lo lus, keratinocytes yog "cim hluav taws xob" ntawm cov xim pigmentation, thaum melanocytes tsuas yog "actuators" ntawm cov cim no. Feem ntau ntawm cov khoom xyaw whitening tsuas yog ua rau lub enzyme system hauv melanocytes thiab tsis tuaj yeem cuam tshuam nrog cov dej ntws ntawm keratinocyte tso tawm cov cim proglomein.
Cov khoom tsim los ntawm Bloomtechz tsis yog nyob ntawm MC1R receptors ntawm melanocytes; nws tseem tuaj yeem tsim qhov 'kev sib tw signaling tsis cuam tshuam' ntawm cov hlwb epidermal.
Thaum keratinocytes tsis tu ncua zais -MSH,Melanostatin DMpreoccupies MC1R binding site ntawm melanocyte daim nyias nyias, ua rau tsis muaj zog ntawm kev sib txuas lus proglobin los ntawm keratinocytes rau melanocytes thiab txiav tawm txoj kev paradermal. Lub niche nam ntawm no mechanism yog hais tias nws tsis ncaj qha inhibit POMC noob qhia tab sis txo melanocytes rhiab heev rau proglomein signals los ntawm keratinocytes. Txawm hais tias keratinocytes tseem tso tawm me me ntawm -MSH, melanocytes tsis tuaj yeem txais tag nrho globin- txhawb cov cim, tiv thaiv lub sijhawm ntev ntawm melanocytes los ntawm kev pheej hmoo qis ntawm proglobin signals nyob rau hauv epidermal microenvironment.
Qhov kev txhawb nqa no, qis- kev siv zog siv zog yog qhov tseeb yog vim li cas qhov chaw hnub ci, melasma, thiab PIH inflammatory pigmentation txuas ntxiv mus thiab nyuaj kho.
Bloomtechz Ntiaj Teb Tag Nrho -Cycle Technology Services
Ua ntej- Kev Muag Khoom: Cov neeg siv khoom thoob ntiaj teb tuaj yeem thov cov qauv rau kev ntsuam xyuas hauv vitro hauv thaj chaw niche xws li 3D epidermal qauv, kuaj melanocyte tsiv teb tsaws, thiab kev tshawb fawb epigenetic; Pab neeg muag ntau hom lus teb sai sai rau cov lus nug, MOQs, lub sijhawm xa khoom, thiab hla - ciam teb kev lis kev cai thiab kev thauj mus los, qhia txog cov kev daws teeb meem ntxiv thiab kev sib xyaw ua ke raws li cov neeg siv khoom lub hom phiaj pigmentation hom thiab cov xim ntawm daim tawv nqaij hauv lub hom phiaj ua lag luam.
R & D cov kev pabcuam: Peb pab pawg peptide thiab cov kws tsim tshuaj pleev ib ce muab cov kev taw qhia kev sib cais, ntsuas kub thiab pH, thiab kev ntsuas kev sib raug zoo rau cov qauv, pab cov neeg siv khoom tsim cov qauv sib txawv rau melasma, PIH, thiab cov tawv nqaij tsis sib xws; Peb tuaj yeem muab cov ntaub ntawv hais txog cov txheej txheem niche tau hais hauv tsab xov xwm no, txhawb cov neeg siv khoom hauv kev sau cov ntawv dawb thiab cov ntsiab lus lag luam; Peb txhawb R & D tej yaam num rau customized purity, tov formulations, thiab peptide hloov kho, tsim tshwj xeeb raw khoom barriers.
Hla- kev xa khoom ciam teb: kev lag luam thoob ntiaj teb kev lag luam, muaj peev xwm xa khoom mus rau Tebchaws Europe, North America, Southeast Asia, Middle East, thiab South America. Txias-qhuav peptides siv qhov kub thiab txias- tswj, lub teeb- tiv taus, ya raws- pov thawj ntim, DHL kev xa khoom tshwj xeeb, ua tiav cov ntaub ntawv, kev pabcuam kev lis kev cai, thiab tiag - sijhawm thauj mus los.
Tom qab-Kev Pabcuam Muag: Tom qab xaj khoom xa tuaj, peb txuas ntxiv ua raws li cov lus pom zoo rau kev sim tshuaj thiab muab kev sib tham txog kev sim tsim muaj feem xyuam rau cov txheej txheem xws li melanocyte tsiv teb tsaws thiab cov xim xim; Peb tsis tu ncua ua raws li kev cai lij choj thoob ntiaj teb kev hloov kho kom zoo nkauj thiab koom tes nrog cov neeg siv khoom thib peb -kev ntsuas kev ua tau zoo ntawm tib neeg los ua kom tiav cov txiaj ntsig kev pov thawj.
Xaiv Phau Ntawv Qhia
Nyob rau hauv lub ntiaj teb no kev ua lag luam rau cosmetic peptide cov khoom xyaw, muaj ntau lwm tus neegmelanostatin DM, tab sis txawv manufacturers sib txawv heev nyob rau hauv synthesis txheej txheem, impurity tswj, stability ntawm kev ua, kev txhawb cov ntaub ntawv, kev tshawb fawb mechanism, thiab hla - cov kev pab cuam ciam teb. Ntau tus neeg yuav khoom thiab cov neeg tsim khoom tsuas yog sib piv cov nqi, saib xyuas qhov chiral purity ntawm D-hom amino acid peptides, ploj lawm / truncated peptide impurities, kev ua haujlwm hloov pauv ntawm cov khoom siv, thiab kev ua tiav ntawm cov ntaub ntawv hauv vitro qauv. Qhov no feem ntau ua rau cov xwm txheej uas qhov me me - ntsuas ntsuas ua haujlwm tau zoo, tab sis qhov ua tau zoo poob qis tom qab teev- nce ntau lawm, cov ntaub ntawv sau npe tsis tiav, lossis kev lis kev cai txawv teb chaws raug txwv. Bloomtechz, vam khom rau nws tus kheej cov khoom siv -theem peptide synthesis ntau lawm kab, tau tsim ib qho kev mob siab rau D- hom amino acid synthesis txheej txheem rau cov khoom no, txawv nws tus kheej los ntawm kev lag luam- hom neeg muag khoom uas outsource intermediates. Cov lus hauv qab no muab kev sib piv kab rov tav nyob rau ntau qhov ntev xws li cov cim qhia lub cev muaj zog, cov yam ntxwv ntawm cov txheej txheem, kev txhawb nqa kev ua tau zoo, kev ua raws li cov ntaub ntawv, muaj peev xwm tsim tau, kev pabcuam kev pabcuam, thiab hla- kev txhawb nqa xa tuaj rau ciam teb, pab R&D thiab pab pawg muag khoom sai sai soj ntsuam cov kev xaiv thiab zam kev tsim thiab sau npe txaus ntshai. Cov ntaub ntawv hauv lub rooj tsuas yog siv rau kev siv xwb.
| Kev sib piv ntawm tej yaam num | Bloomtechz (tus kheej-synthesized ntau lawm) | Cov khoom lag luam tsis tu ncua A (peptide outsourcing / muas intermediates) | Tus neeg muag khoom lag luam B (kev faib tawm dawb huv, tsis muaj kev cob qhia ntau lawm) |
| Customizable cov kev pabcuam | Txhawb kev cai purity, kev cai peptide tov formulations, tshwj xeeb ntim specs, kev cai tshawb fawb-qib qauv; tuaj yeem koom tes nrog kev txiav - ntug kev sim cov phiaj xwm. | Me me -batch purity customization, tsis txhawb kev daws teeb meem kev hloov kho | Tsis txhawb kev hloov kho, tsuas yog tuaj yeem yuav hauv - cov khoom lag luam nrog cov lus qhia tshwj xeeb |
| Cov lus qhia kev ruaj ntseg cia | Ntev-lub sijhawm: khaws cia ntawm -20℃hauv qhov tsaus thiab qhuav; Lub sij hawm luv luv: 2-8℃tub yees; txee lub neej 24 lub hlis, nrog kev txhawb nqa kev ntsuam xyuas kev ruaj ntseg. | Txee lub neej sau npe raws li 24 lub hlis, tsis muaj cov ntaub ntawv ntsuas kev ruaj ntseg nrawm | Tsuas yog daim ntawv teev cov txee lub neej, tsis muaj cov ntaub ntawv ntsuas kev ruaj ntseg, tsis ceeb toom txog kev ya raws lossis siab - qhov kub thiab txias tsis ua haujlwm |
| Ntiaj teb hla- kev pabcuam ciam teb | Paub txog cov tshuaj pleev ib ce ntshuam / xa tawm cov cai hauv Tebchaws Europe, North America, Southeast Asia, thiab Tuam Tshoj; tag nrho cov ntaub ntawv xa tawm, qhov kub thiab txias - tswj cov ntim dej khov ntim kom tsis txhob ya raws thiab lub teeb, DHL nthuav qhia, kev taug qab kev thauj mus los, kev pabcuam kev lis kev cai. | Cov ntaub ntawv xa tawm yooj yim; txheem ntim, tsis muaj kev tiv thaiv kub, yooj yim rau poob kev ua si thaum lub sij hawm ntev - shipping | Tsuas yog lub luag haujlwm rau kev xa khoom, tsis paub txog ntau lub teb chaws cov ntaub ntawv raw cov ntaub ntawv, cov ntaub ntawv yooj yim, kev pheej hmoo ntawm kev lis kev cai siab, tsis muaj qhov kub thiab txias - tswj ntim |
| Tom qab -kev muag khoom txhawb nqa | Kev muag khoom, peptide synthesis, thiab cosmetic formulation multi- pab pawg txhawb nqa; tuaj yeem pab nrog kev sab laj rau - tog neeg thib peb kev sim ua tau zoo ntawm tib neeg thiab cov lus qhia ntawm cov ntaub ntawv sau npe. | Basic tom qab- kev txhawb nqa muag, tsuas yog teb cov lus nug khoom yooj yim; tsis tuaj yeem daws teeb meem kev tsim qauv | Tsis muaj kev tshaj lij tom qab- kev txhawb nqa muag, tsis tuaj yeem taug qab yog tias kev ua haujlwm txawv txav lossis teeb meem kev tsim tawm, tuaj yeem tiv tauj cov chaw muag khoom sab saud |
| Siv tau cov neeg siv khoom scenarios | Rau kev tu tawv nqaij hom R&D, OEM / ODM cov chaw tsim khoom, kev kho mob zoo nkauj channel raw cov ntaub ntawv tsim kho, cov tsev kawm tshawb fawb hauv tsev kawm ntawv, txiav - ntug pigment mechanism kev tshawb fawb. | Cov qauv tshuaj dawb tsis tu ncua, haum rau cov khoom lag luam uas tsis tshua muaj kev xav tau rau impurities thiab chiral purity | Tsuas yog tsim nyog rau ib ntus me me - ntsuas ntsuas nrog cov peev nyiaj tsawg heev thiab cov kev cai qis rau cov khoom siv raw thiab cov ntaub ntawv |
Kev siv
1.ABDEL-MALEK ZA, SWOPE VB, STARNER T, et al. -MSH thiab cov kev cai ntawm melanocyte muaj nuj nqi[J]. Annals ntawm New York Academy of Sciences, 1999, 885(1): 173-192.
2. KADEKARO AL, KANTO H, SWOPE VB, et al. Txhais kev cai MC1R hauv tib neeg melanocytes los ntawm nws cov agonist -melanocortin thiab antagonists agouti signaling protein thiab -defensin 3[J]. Phau ntawv Journal of Investigative Dermatology, 2012, 132(9): 2255-2262.
3.GASPAR LR, MAIA CAMPOS PMB G. Kev koom tes ntawm keratinocyte- thiab fibroblast-derived yam hauv melanocyte homeostasis, cov lus teb rau UV, thiab pigmentary disorders[J]. International Journal of Molecular Sciences, 2022, 23(6): 3274.
4.SCOTT G, LEOPARDI S, PRINTUP S, thiab al. -MSH txhawb nqa tib neeg melanocyte adhesion thiab tsiv teb tsaws ntawm MC1R signaling[J]. Pigment Cell Research, 2002, 15(4): 278-285.
5.ENOMOTO A, SEO J, DENDA M. Protease-activated receptor-2 (PAR-2) mediates melanosome uptake hauv keratinocytes thiab tawv nqaij pigmentation[J]. Experimental Dermatology, 2011, 20(7): 582-586.
Cov lus nug nquag
Q1: Lub caij nyoog ntau lawm puas yuav ua rau qhov tseem ceeb ntawm melanostatin cov sij hawm tsim khoom?
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No. Bloomtechz tau tsim ib qho kev ywj pheej peptide ntau lawm kab rau Melanostatin, cais cov txheej txheem ntau lawm rau cov khoom siv raw thiab niche nquag peptides. Cov qauv kev tshawb fawb thiab me me -batch sim ntau lawm txiav txim muaj cov quotas ntau lawm, kom ntseeg tau tias loj ntau lawm txiav txim tsis muaj neeg coob los yog ncua sij hawm vim lub ncov lub caij, xyuas kom meej nyob rau hauv - sij hawm xa tuaj rau txhua yam ntawm cov neeg muas zaub xaj.
Q2: Ntev npaum li cas -Kev yuav khoom puas tuaj yeem muab cov ntawv pov thawj rau cov txheej txheem sib xws?
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Yog, koj ua tau. Rau cov neeg siv sijhawm ntev -cov neeg siv khoom, peb tuaj yeem tshaj tawm cov lus qhia sib xws, txhim kho tag nrho cov txheej txheem synthesis, purification, thiab khov - cov txheej txheem ziab kom qhuav, nruj me ntsis tswj kev sib txawv ntawm purity, noo noo, thiab cov cim qhia ntawm cov khoom siv, khaws cov qauv batch ib txhij, thiab txhawb cov neeg siv khoom kom tsis txhob muaj kev hloov pauv txhua lub sijhawm.
Q3: Puas yog Melanostatin txhawb nqa segmented kub tswj traceability thaum lub sij hawm qis -kub thauj?
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Txhawb nqa. Cov peptide nquag no yog qhov kub thiab txias -sensitive. Bloomtechz lub siab- kawg xaj tuaj yeem muab tag nrho- txheej txheem segmented kub tswj traceability cov ntaub ntawv, siv qis- kub, lub teeb- zam kev ntim cov hlua txias thoob plaws hauv cov txheej txheem, kaw qhov kev thauj mus los kub ntawm lub sijhawm, tiv thaiv cov khoom siv raw deactivation tshwm sim los ntawm qhov kub thiab txias thiab lub teeb, thiab ua tau raws li cov kev xav tau ntawm kev thauj mus los ntawm qhov kub thiab txias thiab lub teeb, thiab ua tau raws li cov kev xav tau ntawm cov khoom siv siab thiab lub teeb, thiab ua tau raws li cov kev xav tau ntawm cov khoom kub thiab lub teeb, thiab ua tau raws li cov kev xav tau ntawm cov khoom kub thiab lub teeb, thiab ua tau raws li cov kev xav tau ntawm cov khoom siv hluav taws xob.
Q4: Puas muaj kev pabcuam rau rov teem dua yam tsis muaj nqi nplua rau kev rov teem sijhawm thaum tawm ntawm Tshuag?
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Tshwj xeeb ntau lawm locking kev pab cuam yog muab. Rau cov neeg siv khoom lag luam kev nce qib qeeb lossis cov khoom lag luam qeeb, lub peev xwm pub dawb tuaj yeem khaws cia thiab xa mus hloov pauv hloov pauv yam tsis muaj kev nplua ntxiv. Pab pawg muag khoom muab ib qho - ntawm - ib qho ua raws - nce thoob plaws hauv cov txheej txheem, synchronizing peev xwm thiab cov khoom muag ua ntej kom ntseeg tau tias tus neeg siv khoom lub sijhawm ua haujlwm tsis cuam tshuam.
Q5: Puas tuaj yeem hla - kev thauj mus los ntawm ciam teb kom tsis txhob muaj kev tsis sib haum xeeb ntawm kev lis kev cai ntawm peptide raw khoom?
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Yog, koj ua tau. Bloomtechz muaj cov kev pabcuam xa tawm paub tab. Targeting peptide cov khoom ntawm Melanostatin, nws precisely standardizes kev lis kev cai faib, muab tshwj xeeb cov ntaub ntawv thiab ua raws li cov ntaub ntawv, thiab zam cov teeb meem xws li kev faib ua yuam kev thiab kev soj ntsuam nyob rau hauv kaw, zoo heev txhim kho tus ntoo khaub lig- ciam teb xa khoom efficiency thiab xyuas kom meej kev lis kev cai clearance ntawm cov khoom.
Cim npe nrov: melanostatin dm, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom