Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab lwm tus neeg OLIGOPEPTIDE P11-4 CAS 593266-60-5 nyob hauv Suav teb. Txais tos rau lag luam wholesale loj zoo oligopeptide p11-4 cas 593266-60-5 muag ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
OligopTide P11-4, raws li cov oligopthetide, yog kev tsim tawm ntawm ntau cov amino acid cov seem sib txuas los ntawm Peptide Betidues, sib sau ua ke peptide saw. Tus qauv no muab cov khoom ruaj khov rau nws muaj roj ntsha. Tsis tas li ntawd, nws cov amino acid sequence tseem txiav txim nws cov kev sib txawv tshwj xeeb. Feem ntau yog cov khoom pov thawj ua dej solubility zoo. Vim muaj cov pab pawg hydrophilic xws li cov pab pawg carboxyl thiab amino pawg nyob rau hauv nws cov qauv hydrod, nws tuaj yeem tsim cov roj av molecules, yog li ruaj khov nws cov hav dej. Cov solubility zoo no pab kom faib tawm sai thiab ua haujlwm hauv cov kab mob. Lub xeev tsub nqi yog nyob ntawm nws cov txiaj ntsig amino acid uas nws muaj qee qhov kev cuam tshuam zoo lossis tsis zoo nrog cov lwg me me lossis cov chaw ntawm tes nrog cov nqi sib txawv. Ib qho ntxiv, nws cov peev txheej kuj tseem yuav cuam tshuam nws tus cwj pwm hauv kev daws, thiab lwm yam. Zoo biocompatibility, uas tsis muaj qhov kev mob zoo rau tib neeg lub cev. Qhov no ua rau nws muaj kev nyab xeeb thiab ua tau zoo molecule hauv biomedical kev tshawb fawb thiab kev tsim tshuaj. Los ntawm kev tshawb fawb ntxiv thiab kev ua kom zoo dua, nws yuav tsum tau tsim tawm hauv cov tshuaj lossis kev ua haujlwm ntawm kev lom zem.
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Customized raj yas thiab corks:
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OligopTide P11-4yog alpha peptide muaj txog 11 amino acids, nrog amino acids, nrog glutamine phenylomanate glutophan glutopate glutamine glutamine (qqrfewefeqq). Tus peptide tuaj yeem sib sau ua ke los ua cov beta lamellar amylid qauv hauv pal ib puag ncig qis, thiab muaj kev sib cav hydrogel cov khoom. Cov xeeb ceem no ua rau cov tseem ceeb ntawm cov txiaj ntsig tus nqi hauv biomimetic mineralization, enamel tsim dua tshiab, thiab ntawm kev saib xyuas.
1. Siv kev ua haujlwm ntawm cov ntsuas roj ntsha
Nws tus kheej -} Kev sib dhos muaj peev xwm los ntawm tus nqi xa khoom thiab hydrophobicity ntawm nws amino acid seagence. Nyob rau hauv pex tsis tshua muaj kev mob, lub carboxylation ntawm glutamic acid (Arg) los ntawm hydrogenine kev sib koom tes, hydrophobic sib txuas lus, thiab} Π stacking. Cov ntawv no yog txuas ntxiv mus rau hauv nanofiber networks los ua peb - qhov seem hydrogel scaffolds. Qhov scaffold no tuaj yeem ua cov zaub mov tsis zoo rau cov ntsiab lus muaj txiaj ntsig zoo xws li cov calcium carbonate thiab calcium phosphate, simulating ntuj biominerization cov txheej txheem.
2. Khoom cua ntawm high - Kev Ua Tau Zoo Li Cas
Los ntawm kev tswj hwm tus kheej - kev sib dhos cov kev mob ntawm cov tshuaj (kub), cov morphology thiab crystallinity ntawm cov av tso tawm tuaj yeem raug tswj hwm meej. Piv txwv li, hauv calcium phosphate system, lub ceptroxyapatite tsim los ntawm cov qauv hniav nanorod zoo ib yam li 300 MPa, uas yog ze rau 400 MPa ntawm cov hniav txha hniav txhuam hniav ntuj. Cov khoom siv no tau siv hauv kev txhim kho cov pob txha ua kom pom kev, thiab muaj peev xwm txhawb nqa cov pob txha adhesion thiab muaj peev xwm txhawb nqa pob txha cell advents tus nqi piv txwv rau cov ntaub ntawv ib txwm muaj piv rau cov ntaub ntawv.
3. Kev tshawb nrhiav ntawm daim ntawv thov ntawm Organizational engineering
Hauv kev kawm ntawm dentin kev tsim dua tshiab, qhov kev sib cuam tshuam nrog hom kuv collagen fibers yog hais txog. Cov peptide no tuaj yeem siv lub triple helix qauv ntawm collagen thiab tiv thaiv nws qhov kev tsis zoo nyob rau hauv kev ua txhaum. Ntsuas Hluav Taws Xob Cov Khoom Siv Hluav Taws Xob Pom tias muaj cov pob zeb ua kom zoo nkauj nrog OlgopTide P11Fefold zais cia los ntawm Odgophblas tau muab ntau dua los ntawm Olgopthbized nodules nce los ntawm 3 zaug. Ntawm tam sim no, cov cuab yeej technology no tau nkag mus rau theem kev sim ua ntej, nrog lub hom phiaj ntawm kev kho cov hniav looj hniav looj tes los ua los ntawm cov neeg mob kho hniav.
Txwj Laus: Kev tsim kho dua tshiab: kev tawm tsam kev nce qib hauv cov tshuaj noj qhov ncauj
1. Kev Kho Mob Tsis Txaus Siab rau cov neeg kho hniav
Thawj zaug qhia hniav kev kho hniav yog Enamel Demineralization (Ph<5.5), which can penetrate into the demineralized area and self assemble. The peptide scaffold formed by it simulates the function of enamel matrix proteins (such as amelogenin), attracting the deposition of calcium and phosphorus ions in saliva. Clinical studies showed that after a single application of OligopTide P11-4Gel (concentration 0.5mg / ml), cov caries Qhov tob zuj zus los ntawm 0.2 hli ntawm qhov nruab nrab, thiab lub hardness ntawm remineralalized txheej mus txog 70% ntawm lub ntuj enamel. Piv nrog cov tshuaj fluoride (uas txhawb nqa kev tsim cov fluorapatite), peptide indiles hydrodly rau lub cev hniav thiab txo qhov tshwm sim ntawm cov neeg muaj txiaj ntsig ntawm 60%.
2. Kho ntawm txha hniav laus zog micro
Kev kho kom zoo nkauj ntawm txha hniav laus deg tej yam tshwm sim los ntawm acid corrosion lossis kev puas tuaj yeem ua tiav los ntawm kev tsim cov txheej tiv thaiv. Hauv cov kev sim vito tau pom tias tom qab daim ntawv thov no, RA Roughness (RA tus nqi qis dua los ntawm 1.2 μ m rau 80%. Lub tshuab siv hluav taws xob suav nrog:
Kev thaiv lub cev: Cov txheej gel hydraulic tiv thaiv kev nkag mus ntawm cov tshuaj yaj dej kua qaub;
Tshuaj lom neeg: glutamine seem hauv peptide saws fydrogen bonds nrog hydroxyl pawg rau saum npoo ntawm txha hniav laus;
Cov ntxhia induction: txuas ntxiv nyiam calcium ions kom rov ua kom muaj kev poob.
3. Kev ua kom zoo ntawm kev ua ke kho lub tswv yim
Nws cov ntawv thov Composite nrog nano hydroxyapatite (NHA) tau dhau los ua cov kev tshawb nrhiav hotspot. NHA muab cov ntxhia ua ntej thiab cov kev npaj ua haujlwm los ntawm tus kheej {{}} kev sib dhos. CANINE cov kev sim tau pom tias cov ntxhia hauv cov ntaub so ntswg tsis zoo los ntawm cov khoom siv tsis zoo los ntawm tsawg dua 5%, thaum qhov sib txawv siv NHA ib leeg yog txog li 15%. Tam sim no, cov thev naus laus zis tau tsim mus rau ob -}}} sib xyaw ntawm cov khoom siv rov qab los ntawm qhov ncauj rov qab, txo cov haujlwm hauv chaw kuaj mob li 10 feeb.
1. Cov Cheebtsam Tub Ntxhais Hluas ntawm Kev Tiv Thaiv Kev Tiv Thaiv Gel
Nws yog ntxiv rau cov dej -} Raws li gel (siab 0.1-0.3mg / ml) los ua si lub luag haujlwm ntawm kev tiv thaiv kev sim los ntawm cov kev ntsuas hauv qab no:
Acid Buffering: Glutamic acid seem nyob rau hauv peptide chains tuaj yeem nruab nrab ntawm qhov ncauj pH ntawm 4.5 txog 5.8;
Tshuaj tua kab mob: inhibits tsim ntawm Streptococcus Mutans Biofilm thiab txo cov adhesion txo los ntawm 70%;
Re Mineralization: Tom qab siv ob zaug nyob rau ib hnub rau 3 lub hlis, lub cev ntawm cov hniav cuav ntawm kev kawm hniav ntawm lub cev tau txog 85%.
Cov kev kho mob randomized tswj kev sim (RCT) suav nrog 200 tus neeg mob uas muaj cov neeg mob ntshav siab. Cov txiaj ntsig tau pom tias cov neeg muaj txiaj ntsig nres tus nqi (92%) ntawm cov pab pawg uas siv cov pab pawg Oligopeptide tau nce siab dua li cov pab pawg fluoride (78%).
2. Kev ntshiab ntawm cov hniav rhiab
Qhov qhib ntawm cov leeg me me tshwm sim los ntawm kev kho hniav yog qhov ua rau muaj kev mob siab. Nws tuaj yeem nkag mus rau hauv cov raj me me (mus txog rau ib qhov tob ntawm 20 μ m) thiab tsim kho tshuab thaiv tom qab tus kheej- kev sib dhos. Laser ua rau lub tswv yim tawm tswv yim pom tau tias tom qab daim ntawv thov ntawm lub tubules, txoj kab uas hla ntawm lub tub yaj tau nce ntawm 4 zaug. Piv nrog potassium nitrate (cov hlab ntaws desensitization), nws muaj qhov nrawm dua ntawm kev nqis tes ua (1 lub lim tiam vs 2 lub lis piam) thiab tsis muaj kev phiv xws li tus nplaig ib yam li tus nplaig.
3. Kev loj hlob ntawm cov khoom lag luam tshiab ntawm qhov ncauj
Raws li nws cov kev tshawb fawb thiab kev tsim kho cov khoom lag luam, suav nrog:
Txawj ntse teb cov tshuaj txhuam hniav: uas muaj pho tsom tsom iav, tso tawm ntawm PH theem qis;
Cov tshuaj mucosal: siv rau cov pos hniav kev puas tsuaj los ntawm kev kho mob epithelial epithelial kev tsim dua tshiab;
Cov tshuaj yaug qhov ncauj: ua ke nrog CPC (Clopidogrel chloride) los txhim kho cov nyhuv tua kab mob, txo cov quav hniav los ntawm 50%.
Kev tshawb fawb kev lag luam qhia tau hais tias cov khoom pab tu qhov ncauj muaj li 25%, thiab nws tau txais kev lag luam thoob ntiaj teb yuav ntau dua 500 lab daus las los ntawm 2025.
Txheej txheem cej luam ntawm Kuaj cov qauv kev rauOligopTide P11-4:
Xaiv cov amino acid sequence: xaiv cov amino acid sequence raws ntawm cov ntawv thov phiaj. Txhim kho cov kev ua haujlwm uas yuav tsum tau yog qhov kev txiav txim siab thawj zaug.
Oligopeptide chains are prepared by solid-phase peptide synthesis (SPPS) or liquid-phase peptide synthesis (LPPS). Ntawm lawv, cov khoom -}}}} theem peptide synthesis yog ib txoj kev nquag siv.
Thaum lub sij hawm synthesis, nws yog ib qho yuav tsum tau ua kom raws sijhawm rau pawg tiv thaiv, yog li ntawd cov amino acid residue nthuav tawm lub chaw ua haujlwm kom koom nrog hauv kev xav tom ntej. Cov pab pawg tiv thaiv ib txwm muaj xws li FMOC, BOC, thiab lwm yam.
Cov kev cuam tshuam hws ntawm cov amino pab pawg thiab cov pab pawg carboxyl los tsim cov pab pawg peptide. Cov kauj ruam no yuav tsum siv kev siv Coupling Reagents thiab txhawb kom pab txhawb cov tshuaj tiv thaiv.
Rov ua cov theem ntawm kev tsis txaus siab, txuas ntxiv, thiab lwm yam kom txog thaum qhov xav tau ntawm Oligopeptide ntev yog synthesized.
Kev ua kom huv thiab cov cim: cov synthesized oligopeptides thiab tus cwj pwm los ntawm cov hau kev xws li high {0 pl pl {liquid liquid liquid liquid liquid liquid liquid {{້ອມ (HPLC) thiab Mass Spectrometry (MS). Ua kom ntseeg tau tias nws cov kev coj dawb huv tau raws li kev sim yog qhov tseem ceeb heev.
Ua raws li synthesized oligopeptides rau phiaj teb xws li Kev Tshawb Fawb Biomedical, kev tsim tshuaj, thiab lwm yam rau kev ntsuas thiab kev tshuaj ntsuam xyuas.
Ntawm no yog qhov piv txwv yog qhov piv txwv ntawm cov tshuaj tiv thaiv tshuaj lom neeg: noj cov khoom siv}}}} awnume residages, tus activator yog DEAA, thiab lub coamling reagent yog btaa.
R1- nh2+ Fmocc el → r1{{0- nh - fmoc + hcl (kev hloov pauv hloov)
R1{{0- nh - fmoc + dea → r1- nh2+ FMOC DISA (DEPROTIONS Cov Yam ntxwv
R2- Cooh + BTAA → R2- coo - btaa (esterification cov tshuaj tiv thaiv)
R1-nh2+R2- coh → r1 {- nh- c (o) -nr2+H2O (kev tawm tsam hws)
HBB → r1- nh2+R2- Cooh + n- bromoacetamide (acid hydroletamide tshem cov pab pawg tiv thaiv kom tau txais cov saw hlau oligoptide)
Cim npe nrov: OligopTide P11-4 li 593266-60-5, Tuam Tshoj chaw tsim khoom, chaw tsim khoom, chaw tsim khoom, yuav, nqe, loj, rau muag