Tianepine sodium ntsev(txuas:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/tianeptine-sodium-salt-cas-30123-17-2.html), tseem hu ua Tianepine sodium ntsev, yog cov organic compound nrog ntau yam kev ua haujlwm lom neeg uas tau kawm dav thiab siv hauv kev kho mob thiab kev tshawb fawb. Cov qauv molecular ntawm Tianepine muaj ib lub nplhaib triazole, chlorophenyl heterocycle, thiab ib lub nplhaib naphthalene, nrog plaub oxygen atoms thiab ob lub nitrogen atoms. Nws cov mis mos molecular yog C21H25ClN2O4S, nrog rau qhov hnyav molecular ntawm 437.0, thiab nws belongs rau tricyclic compound. Lub ntsiab pharmacological nyhuv yog tswj cov uptake thiab tso tawm ntawm cov neurotransmitter 5-hydroxytryptamine (5-HT) kom siv tshuaj tua kab mob, tiv thaiv kev ntxhov siab, txhim kho kev nco thiab kev txawj ntse, neuroprotective, thiab tiv thaiv qaug zog. Nws cov txheej txheem ntawm kev ua haujlwm yog qhov tshwj xeeb thiab txawv ntawm lwm cov tshuaj tiv thaiv kev ntxhov siab. Nws muaj cov tshuaj tiv thaiv kev ntxhov siab thiab tuaj yeem ua rau kom muaj zog ntawm 5-HT thiab norepinephrine hauv lub hlwb, thaum tswj hwm dopamine thiab - Qib ntawm aminobutyric acid. Qhov no ua rau Tianepine txo cov kev ntxhov siab ntsig txog cov tsos mob xws li kev ntxhov siab dav dav thiab kev phobia. Nws tuaj yeem txhim kho kev nco thiab kev paub txog kev ua haujlwm, feem ntau yog los ntawm kev nce siab ntawm dopamine thiab norepinephrine hauv lub hlwb thiab tswj kev tso tawm ntawm lub hlwb-derived neurotrophic yam. Qhov no tso cai rau Tianepine siv los kho cov kab mob neurocognitive xws li kev tsis pom kev tsis txaus siab hyperactivity teeb meem.
Raws li cov khoom lag luam muaj ntau yam kev siv, tib neeg xav paub ntau ntxiv txog nws txoj kev tshawb fawb. Hauv cov lus piav qhia hauv qab no, peb yuav muab cov lus piav qhia ntxaws txog cov txheej txheem sib xyaw ua ke.
Txoj kev 1
Kev npaj cov khoom siv raw:
(1) O-Nitrochlorobenzene
O-nitrochlorobenzene yog ib hom organic synthesis raw khoom uas tuaj yeem tau txais los ntawm kev yuav khoom lossis tshuaj synthesis txoj kev. Cov qauv qauv ntawm o-nitrochlorobenzene yog C6H4ClNO2, nrog rau qhov hnyav molecular ntawm 153.5.
(2) Sodium nitrite
Sodium nitrite yog cov ntsev inorganic uas tuaj yeem npaj tau los ntawm cov tshuaj tiv thaiv ntawm soda tshauv thiab nitric acid, los yog yuav ncaj qha. Cov qauv qauv ntawm sodium nitrite yog NaNO2, nrog rau qhov hnyav molecular ntawm 69.0.
(3) Ammonium chloride
Ammonium chloride yog cov ntsev inorganic uas yooj yim soluble hauv dej thiab tuaj yeem npaj tau los ntawm kev ua pa ammonia thiab chlorine gas, los yog yuav ncaj qha. Cov qauv qauv ntawm ammonium chloride yog NH4Cl, nrog rau qhov hnyav molecular ntawm 53.5.
(4) Dej
Dej yog qhov hnyav tshaj plaws hauv chav kuaj thiab tuaj yeem siv los yaj cov khoom siv raw thiab cov khoom.
Synthesis cov kauj ruam:
(1) Sib tov o-nitrochlorobenzene, sodium nitrite, ammonium chloride, thiab dej ua ke, cua sov kom npau npau, thiab lub sijhawm tshuaj tiv thaiv yog li 30 feeb mus rau 1 teev.
(2) Tom qab cov tshuaj tiv thaiv tiav, ntxiv cov tshuaj sodium hydroxide uas tsim nyog los kho tus nqi pH mus rau thaj tsam 7, tom qab ntawd ntxiv qhov tsim nyog ntawm cov pa roj carbon activated, cua sov thiab boil rau ob peb feeb.
(3) Lim thiab tshem tawm cov pa roj carbon activated, txias cov tshuaj, thiab precipitate crystals. Do nrog lub iav pas nrig thiab lim cov muaju kom tau txais cov khoom lag luam Tianeptine crude.
(4) Ntxiv cov crude Tianeptine rau cov dej uas tsim nyog thiab ua kom sov rau hauv lub xeev yaj. Ntxiv qhov tsim nyog ntawm sodium hydroxide tov los kho tus nqi pH rau ib ncig ntawm 7, tom qab ntawd ntxiv cov nyiaj tsim nyog ntawm cov pa roj carbon activated, cua sov thiab boil rau ob peb feeb.
(5) Lim thiab tshem tawm cov pa roj carbon activated, txias cov tshuaj, thiab precipitate crystals. Do nrog lub iav pas nrig thiab lim cov muaju kom tau Tianeptine cov khoom zoo.
(6) Ntxuav thiab qhuav lub Tianepine boutique kom tau txais cov khoom kawg Tianepine sodium ntsev.
Txoj kev 2
Npaj cov khoom siv raw
(1) O-Nitrochlorobenzene
O-nitrochlorobenzene yog ib hom organic synthesis raw khoom uas tuaj yeem tau txais los ntawm kev yuav khoom lossis tshuaj synthesis txoj kev. Cov qauv qauv ntawm o-nitrochlorobenzene yog C6H4ClNO2, nrog rau qhov hnyav molecular ntawm 153.5.
(2) Aniline
Aniline yog cov khoom siv hluavtaws organic uas tuaj yeem npaj los ntawm cov tshuaj tiv thaiv ntawm ammonia thiab chlorine gas los yog yuav ncaj qha. Cov qauv qauv ntawm aniline yog C6H7N, nrog rau qhov hnyav molecular ntawm 109.1.
(3) Sodium acetate
Sodium acetate yog cov ntsev organic uas yooj yim soluble hauv dej thiab tuaj yeem npaj tau los ntawm kev ua haujlwm ntawm acetic acid nrog sodium hydroxide, los yog yuav ncaj qha. Cov qauv qauv ntawm sodium acetate yog CH3COONa, nrog rau qhov hnyav molecular ntawm 134.9.
(4) Salicylic acid
Salicylic acid yog cov organic acid uas tuaj yeem npaj los ntawm reacting salicylaldehyde nrog acetic anhydride los yog yuav ncaj qha. Cov qauv qauv ntawm salicylic acid yog C6H4 (OH) (COOH), nrog rau qhov hnyav molecular ntawm 138.1.
(5) Dej
Dej yog qhov hnyav tshaj plaws hauv chav kuaj thiab tuaj yeem siv los yaj cov khoom siv raw thiab cov khoom.
Synthesis cov kauj ruam:
(1) Sib tov o-nitrochlorobenzene, aniline, sodium acetate, thiab salicylic acid ua ke, tshav kub rau lub xeev reflux, thiab lub sij hawm cov tshuaj tiv thaiv yog li ntawm 30 feeb mus rau 1 teev.
(2) Tom qab cov tshuaj tiv thaiv dhau lawm, ntxiv cov nqi tsim nyog ntawm hydrochloric acid. Thov txim rau qhov kev cuam tshuam tsis txaus ntseeg ntawm cov lus teb dhau los. Cov hauv qab no yog cov kauj ruam ua tiav rau qhov thib ob hom kev sim ua ke ntawm Tianeptine sodium ntsev:
(3) Tom qab cov tshuaj tiv thaiv tiav, ntxiv cov tshuaj sodium hydroxide uas tsim nyog los kho tus nqi pH mus rau thaj tsam 7, tom qab ntawd ntxiv qhov tsim nyog ntawm cov pa roj carbon activated, cua sov thiab boil rau ob peb feeb.
(4) Lim thiab tshem tawm cov pa roj carbon activated, txias cov tshuaj, thiab precipitate crystals. Do nrog ib lub iav pas nrig thiab lim cov muaju kom tau txais Tianeptine crude.
(5) Ntxiv cov crude Tianeptine mus rau qhov tsim nyog cov dej thiab ua kom sov rau hauv lub xeev yaj. Ntxiv qhov tsim nyog ntawm sodium hydroxide tov los kho tus nqi pH rau ib ncig ntawm 7, tom qab ntawd ntxiv cov nyiaj tsim nyog ntawm cov pa roj carbon activated, cua sov thiab boil rau ob peb feeb.
(6) Lim thiab tshem tawm cov pa roj carbon activated, txias cov tshuaj, thiab precipitate crystals. Do nrog lub iav pas nrig thiab lim cov muaju kom tau txais Tianeptine zoo.
(7) Ntxuav thiab qhuav lub Tianepine boutique kom tau txais cov khoom kawg Tianepine sodium ntsev.