Cimetidine Creamyog cov qauv sib txuas lus tshaj plaws, nrog nws cov tseem ceeb, Cimetidine, ua haujlwm ua H ₂ receptor kev thaiv av. Los ntawm thaiv cov binding ntawm cov kab mob ntawm cov tshuaj heramine mus rau h ₂ receptors hauv cov roj av lub plab, nws tseem ceeb ua pa roj hnyuv. Cov txheej txheem no tau txuas ntxiv rau cov teb ntawm anti - kev cai thiab kev tiv thaiv tsis taus thaum ua tiav. Nws cov qauv sib xyaw ua ke feem ntau txuas ntxiv cov kua roj salicylic acid, acyclovir, lidocaine thiab lwm yam khoom xyaw los ua ntau- hom phiaj kho cov nyhuv. Nws ib nrab {{6- lub neej yog li 1.5-2 teev, thiab nws qhov ncauj bioavailability mus txog 60-70%. Nws yog tsuas yog siv nyob rau hauv cov kws kho mob xyaum ua kom kho lub plab acid ntsig txog cov kab mob. Txawm hais tias cov qauv ua kom dawb yog siv hauv tib neeg cov tshuaj rau cov tawv nqaij thiab cov tshuaj pleev cov tsiaj, thiab cov ntsiav tshuaj cream tau siv ntau dua raws li cov lus qhia kho mob.
Tub ntxhais mechanism ntawm kev nqis tes ua
Gojic acid supression:
Blocks hosmine ua rau cov kua txob pa roj av, txo qis cov pa roj plab pH, thiab kev mob rwj.
Kev tiv thaiv kab tiv thaiv kab mob:
Los ntawm inhibiting t lymphocyte kev ua, txo qhov tso tawm ntawm cov kev kho mob ntawm -} cov kab mob mediated.
Antitumor txhawb:
Thaum muaj Mastocytoma, nws tuaj yeem tsim cov kev tso tawm hauv cov qog thiab qeeb qeeb.
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
Peb Cov Khoom Daim Ntawv
Cimetidine +. coa
Cov chaw kuaj mob tshwj xeeb thiab cov ntaub ntawv ntau npaum li cas rau cov tsiaj
Siv tau cov xwm txheej rau kev siv tshuaj ntau dua
Cov ntsiav tshuaj 100mg, 150mg, 200mg yog muab rau ntawm cov tshuaj tsis tu ncua rau dev thiab miv
Qhov ncauj daws 300mg / 5mL rau cov menyuam mos lossis qee kis ntawm kev nqos nyuaj
Cov Tshuaj Txhuam 100Mg / ntsiav tshuaj (tsw qab) los txhim kho tsiaj noj tshuaj ua kev ua tiav
Cov Lus Qhia Tshwj Xeeb: 150Mg / ML (5ML Ampoule)
Muaj feem cuam tshuam cov xwm txheej:
Kev Tawm Tsam Gastricc lossis Cov Hluav Taws Xob Perforation
Kev tiv thaiv ntawm PostOperative Ulcers
Cov teeb meem tseem ceeb uas tsis tuaj yeem raug cob qhia
Cimetidine Cream: Ib tug matrix mis muaj 2% CIMETIDINE, rau daim ntawv thov hauv zos tsuas yog raws li cov kws kho tsiaj, xws li:
Daim ntawv thov ntawm qhov ncauj (yuav tsum muaj kev sib koom tes nrog kev kho qhov ncauj tsev)
Cov nyiaj them saum npoo ntawm cov tawv nqaij mob txhab (ua haujlwm tsis huv)
Kev saib xyuas lub qhov muag (yuav tsum tau kho cov pab raws li cov lus sib piv)
Cov phiaj xwm tsiaj tshwj xeeb cov phiaj xwm thiab tshuaj ntau
1. Cov ntsiab cai yooj yim
Cov dev: 3-5mg / kg lub cev hnyav, txhua 6-8 teev
Miv: 5-10Mg / Kg lub cev hnyav, txhua 8-12 teev
Tshwj Xeeb:
Mast cell qog: 10-20mg / kg, ob zaug ib hnub
Tshuaj esophagitis: 5-10mg / kg, 4 zaug ib hnub
2. Piv txwv ntawm formatation hloov dua siab hloov pauv
Rooj plaub: IB 15kg Aub yuav tsum muaj cov tshuaj (300mg / 5ml)
Ib qho koob tshuaj: 15kg × 5mg / kg =75 mg
Yuav tsum tau daws cov ntim: 75mg ÷ (300mg / 5ml) =1.25 ml
3. Kev ua kom zoo ntawm kev tswj hwm txoj kev
Kev Tswj Xyuas Qhov Ncauj:
Tswj hwm ntawm lub plab khoob (30 feeb ua ntej noj mov) kom nce tus nqi nqus
Cov ntsiav tshuaj tuaj yeem qhwv hauv cheese lossis cov hnyuv ntxwm
Cov kev daws yuav tsum tau maj mam txav mus rau hauv kaum lub qhov ncauj siv cov koob txhaj tshuaj
Txhaj koob tshuaj tiv thaiv:
Kev txhaj tshuaj tiv thaiv kev txhaj tshuaj yuav tsum tau ua rau 1mg / ml thiab lub sijhawm txhaj tshuaj ntau dua los yog sib npaug rau 2 feeb
Kev txhaj tshuaj rau cov leeg leeg xaiv cov leeg cov leeg ntawm cov leeg ntawm cov ceg tawv
Kev Ntsuam Xyuas Cov Ntaub Ntawv
Rooj plaub 1: ib 8 {{{- xyoo tus tswv yug yaj nrog Chronic tsis ua hauj lwm thiab pais plab
Kev daws:
CIMETIDINE 3MG / KG Q12h ntawm
Ua ke saib xyuas ntawm 1g Q8h Txhuas Sulfate ua ntej noj mov
Saib xyuas cov ntshav muaj txuj ci thiab kua txiv kua pH qhov chaw
Qhov tshwm sim: Ulcer zoo tom qab 2 lub lis piam thiab tswj kev kho mob rau 3 lub hlis yam tsis muaj kev rov muaj dua
Rooj plaub 2: 3 {-} xyoo-laus Maine Coon miv, postroperative mastocytaivoma
Kev daws:
Cimetidine 10mg / kg kev sib tw intravenous Txoj kev lis ntshav
Kev sib xyaw ua ke ua ke 2mg / kg ofally
Saib xyuas cov kev muaj keeb kwm txhua qhov 2 asthiv
Qhov tshwm sim: Cov qog kev loj hlob Inhibition tus nqi tau mus txog 65%, thiab lub sijhawm muaj sia nyob tau txuas mus rau 14 lub hlis
Kev sib cuam tshuam ntawm ntau yam ntau yam thiab lub tsev kho mob science
1. Ntau yam sib txawv
Vim MDR1 Mene, kev sib hloov pauv Gene, kev sib tsoo tau nkag siab ntau dua rau lub nruab nrab Neurotoxicity ntawm Cimetidin thiab yuav tsum tau txo cov tsos mob neurological thiab saib cov tsos mob neurological.
2. Cov teeb meem tseem ceeb
Hauv cov mob septic kev lom zem, kev sib xyaw nrog cov tshuaj sib xyaw xws li dopamine yuav ua rau cov kab mob plab zom mov vim muaj mob plab hnyuv sab nrauv, ua rau muaj kev pheej hmoo kis mob. Qhia txog kev siv proton tsoos nyuj inhibitors (xws li omeprrazole) hloov.
3. Mob qog compressvant txoj kev kho
Thaum muaj Mastocytoma, kev sib xyaw ua ke ntawm Cimetidin thiab LOperamide tuaj yeem txhim kho kev cuam tshuam, tab sis ceev faj yuav tsum tawm tsam kev phiv quav ntsej muag. Nws raug nquahu kom soj ntsuam qhov zaus ntawm kev ua haujlwm ntawm cov quav thiab tswj cov lactulose rau kev tso quav yog tias tsim nyog.
4. Kev Siv Tshuaj Kho Mob
Thaum Cimetidin yog siv hauv kev sib xyaw nrog mifwmilitone, cov xyoob ntoo ntawm cov tom kawg yuav txo tau los ntawm 30% thiab txoj kev tshem ntshav tshem tawm tuaj yeem nce ntxiv. Yog li, siv yuav tsum zam. Hauv kev tshawb fawb cuam tshuam nrog ntau tus neeg mob myeloma, T1 / 2 ntawm Melphalan txo qis los ntawm 1.57 teev tom qab tswj hwm, qhia tias muaj kev ua tau zoo.
Cimetidine Cream, raws li ib qho classic h ₂ receptor kev thaiv kev thaiv, yog siv dav hauv kev kho mob ntawm cov kab mob hnyuv, thiab cov tshuaj tsw qab ntawm cov pa roj hnyuv. Txawm li cas los xij, nws cov tshuaj muaj kev siv tshuaj yog cov nyom, koom nrog kev cuam tshuam txog kev sib xyaw xws li, thiab cov tshuaj ntsiav Cov hauv qab no muab cov ncauj lus kom ntxaws tshuaj xyuas los ntawm plaub yam: metabolic enzyme inhibition, daim siab ntshav kev sib xyaw, thiab cov khoom sib txuam tshwj xeeb thiab cov xwm txheej tshwj xeeb thiab chaw kuaj mob tshwj xeeb.
Cov Engic Enzyme Inhibition: Core cuam tshuam ntawm CYP450 system
CIMETIDINE yog qhov muaj zog inhibitor ntawm CYP450 enzyme system, tshwj xeeb tshaj yog kev nthuav qhia tseem ceeb inhibitaush2, Cyp2D6, thiab CYP3A4 subtypes. Qhov kev txwv tsis pub loj no ua rau lub qeeb qeeb ntawm cov metabolism hauv ntau yam tshuaj, kev nce hauv cov tshuaj hauv cov tshuaj muaj tshuaj tiv thaiv ntshav, thiab tom qab ntawd ua rau muaj kev lom zem.
1. Anticoagulants
Thaum ua ke nrog warfarin, cimetidin tuaj yeem txo nws cov metabololic ntawm 30% -50%, ua rau muaj kev nce qib siab tshaj plaws (INR). Cov neeg kuaj mob tau pom tias cov koob tshuaj tiv thaiv Warfarin yuav tsum tau txo los ntawm 25% -50% tom qab sib xyaw ua ke kom tsis txhob muaj kev los ntshav. Piv txwv li, tus neeg mob uas tau noj cov neeg ua rog rau lub sijhawm ntev uas tau ntsib cov zais pa thiab sab nrauv vim yog kev sib xyaw ua ke ntawm Cimetidine. Tom qab kho cov nqi, cov tsos mob txhim kho.
2. Antiepileptic tshuaj
Thaum phenytoin sodium ua ke nrog Cimetidine ua ke, nws cov ntshav hlwb nce los ntawm qhov nruab nrab ntawm 28%, thiab qee kis kev nthuav dav nruab nrab ntawm cov leeg ntshav lom zem (xws li ataxia thiab tshee tshee). Hauv ib qho kev tshawb fawb txog 11 tus neeg mob Epilepsy pom tias muaj pob khaus loj los yog kev mob phenytoin lom cov tsos mob tom qab kho kev kho. Yog li ntawd, nws yog ib qho tsim nyog los kho cov tshuaj ntawm phenytoin sodium rau qhov qis dua ntawm kev kho mob thiab saib xyuas cov tshuaj hauv cov ntshav tshuaj.
3. Benzodiazepines
Thaum Diazepam yog ua ke nrog Cimetidine ua ke nrog Cimetidine, nws tshem tawm ib nrab {{0%, thiab cov confentration ntawm cov tshuaj pub dawb, ua rau kev ua kom muaj kev qaug tshuaj ntau dhau. Piv txwv li, tus neeg mob yuav muaj kev tshaib plab thiab qeeb teb tom qab tswj hwm, tab sis cov tsos mob tshwm sim txhim kho kev siv tshuaj. Nws raug nquahu kom txo cov koob tshuaj ntawm diazepam los ntawm 30%, lossis hloov mus rau H ₂ receptor kev tiv thaiv xws li ranitidine uas tsis muaj enzyme inhibe cuam tshuam.
4. Cov tshuaj antiarrhythmic
Thaum cov neeg txua khoom tau sib xyaw nrog Cimetidine, nws ib nrab ntawm {{0%}}}}}}} Lub neej ntawm cov metabolite N-acetylprocainamide tseem muaj kev txo qis. Qhov no yog ua pov thawj tshwj xeeb hauv cov neeg laus thiab cov neeg mob uas tsis muaj lub npe rau electrocardioriogram thiab ntshav tshuaj contrical los kho ntau npaum li cas.
Txo cov ntshav ntshav ntws hepatic flow: indirect inhibition ntawm kev siv tshuaj yeeb
CIMETIDINE txo cov tshuaj metabolic tus nqi ntawm cov tshuaj uas vam meej ua ntej daim siab ntshav ntws, ua rau muaj kev ua kom muaj ntshav ntau ntxiv.
1. Lidocaine
Thaum siv cov kev sib xyaw ua ke, qhov kev tshem tawm tus nqi ntawm Lidocaine txo qis los ntawm kev txo qis qis, uas tuaj yeem ua rau muaj kev mob siab rau nruab nrab (xws li tsaug zog thiab mob siab). Nyob rau hauv cov rooj sib xws ntawm myocardial infarction, kev saib xyuas koob tshuaj ntawm liidocaine yuav tsum raug txo los ntawm 20% -30% tom qab sib xyaw, thiab cov tshuaj tua ntshav siab yuav tsum tau saib xyuas.
2. Propranolol
Thaum siv cov kev sib xyaw ua ke, cov ntshav cov ntshav nce los ntawm 2-3 zaug, coj mus rau Bradycardia thiab hypotension hypotension. Cov tswv yim hauv chaw kho mob yog los saib xyuas lub plawv thiab ntshav siab, thiab yog tias tsim nyog, hloov mus rau kev sib xyaw ntawm nadole (Naphthodim) feem ntau ua tiav los ntawm ob lub raum thiab lub ntsej muag.
3. Amiodarone
Lub serum concentration ntawm amiodarone nce los ntawm qhov nruab nrab ntawm 38% thaum siv ua ke, tab sis muaj kev sib txawv. Tom qab ntxiv Cimetidine rau 12 tus neeg mob uas tau txais 200mg / d amiodarone, 8 ntawm lawv pom tias muaj kev nce siab hauv cov cuav siab, thaum 4 tseem tsis hloov lossis poob qis. Kev siv ntshav tau xav tau kev saib xyuas thiab kev siv tshuaj kho kom haum raws sijhawm.
Pharpacyamic sib txuam: superposition ntawm ntau qhov system cuam tshuam
Thaum txhuas hydroxide thiab lwm yam antacids yog siv ua ke nrog Cimetidine, lawv cov bioavailability tuaj yeem txo los ntawm 20% -30%. Xav qhia kev sib cais tshwj xeeb (noj tshuaj tiv thaiv 1 teev ua ntej lossis 2 teev tom qab Cimetidine). Hnasav cov tshuaj muaj zog xws li Metocloramide yuav tsum tau hloov kho kom thiaj li ua kom nrawm nrawm ua pa thiab txo cov nqaij ci ntsa iab. Cov thawj coj tau ua ntu zus yuav tsum tau muab ua ntej, ua raws li Cimetidin 30 feeb tom qab.
CIMETIDINE tuaj yeem sib tw khi rau Andresen Receptors, thiab ntev {-}}} kev siv lub mis (nrog qhov muaj feem kwv yees li 1% -2%). Hauv kev kho ntawm cov txiv neej tsiaj, nws yog qhov tsim nyog los ntsuas seb cov nyiaj hormones sib deev qib ua ke thiab, yog tias tsim nyog, siv Androgen Tshuaj hauv kev sib xyaw ua ke.
Tetralcycline:Cimetidine CreamNce lub pH hauv plab, ua rau kom txo qis hauv kev sib cais ntawm tetracycline ntsiav tshuaj tsis muaj kev cuam tshuam.
Linmomycin: Thaum siv ua ke, cov neeg mob ntshav siab txog lub labincin nce los ntawm 19%, thiab nws cov bioavailability nce los ntawm 27%. Tshwj xeeb tshaj yog nyob rau hauv lub siab thiab lub raum tsis sib xws, ntshav kev soj ntsuam lossis kev txo nqi tau.
Chloramphenicol: Ob qho tib si tuaj yeem ua rau Marrow pob txha, thiab muaj kev pheej hmoo ntawm kev tsis txaus ntseeg ntawm cov tshuaj tsis txaus ntseeg thaum siv ua ke.
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