Shaanxi Bloom Tech Co., Ltd. yog ib qho kev paub txog cov neeg tsim khoom thiab cov chaw muag khoom ntawm paj paj ntau 75330-75-5 hauv Suav teb. Txais tos rau kev lag luam wholesale ntau zoo trucksatin CAS75330-75-5 kev muag khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Txiv nyiamyog cov organic sib xyaw nrog cov tshuaj noj ntawm C24h36o5 thiab CAS6 {4 {4} - 5. Nws yog lipid -} cov roj hmab qis dua ntawm cov roj (cholesteroles) thiab nce synthesis ntawm cov roj qis qis- qhov lasprotein deleptor. Nws lub luag haujlwm tseem ceeb yog nyob hauv daim siab. Raws li qhov tshwm sim, cov qib ntshav roj thiab cov roj cholesterol tsawg yog txo qis, uas muaj tus mob atheroscleros thiab mob plawv. Nws yog tus dawb kom tawm dawb crystalline hmoov, tsw ntxhiab, tsis muaj qab hau, thiab hygroscopic me ntsis. Nws muaj qee qhov solubility hauv cov kuab tshuaj yeeb yaj kiab xws li ethanol, acetone, ethyl acetate, lossis acetonitrile. Nws yog yooj yim soluble hauv chloroform thiab soluble hauv ethanol ntawm kev xav ntawm 9.80-10.20 mg / mL (ntshiab, tsis muaj xim rau lub teeb daj). Lipid-txo cov nyhuv feem ntau yog vim muaj cov pab pawg ua haujlwm hauv nws cov qauv, uas tuaj yeem sib tw ntawm HMO Reductase, yog li txo cov tshuaj synthesis. Nws cov qauv ib nrab, 3,5-Dihyrdroxyheptoic acid, yog li ntawm HMG COA thiab muaj zog thaiv cov roj biosynthesis txoj kev ntawm cov roj (cholesterol.
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Tshuaj Cov Qauv |
C24H36O5 |
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Muaj pes tsawg leej |
404 |
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Molecular hnyav |
405 |
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m/z |
404 (100.0%), 405 (26.0%), 406 (2.7%), 406 (1.0%) |
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Kev Ntsuam Xyuas |
C, 71.26; H, 8.97; O, 19.77 |
Txiv nyiam, raws li ib qho tseem ceeb ntawm cov tshuaj muaj txuj ci, feem ntau yog ua tau los ntawm cov hau kev hauv qab no:
1. Microbial Fermentation Txuj Ci
Qhov no yog txoj kev los ntawm uas nyiam nyiam thiab npaj tau. Xyoo 1970, Japanese cov kws tshawb fawb thawj zaug cais cov tshuaj mevastatin, uas muaj peev xwm ua rau inhibit ua si, los ntawm cov metabolites citrinum. Tom qab, cov kws tshawb fawb tau txais kev nyiam nyiam kev nyiam ua ke ntawm kev ua si broth ntawm lwm cov khoom noj khoom haus. Cov qauv no siv rau cov txheej txheem metabolic ntawm cov kab mob metabolic los tsim cov phiaj xwm txuas thiab muaj cov nqi ntau ib puag ncig thiab ib puag ncig cov phooj ywg.
2. Semi synthetic txoj kev
Txoj kev hluavtaws synthetic siv los ntawm kev nyiam ua kom muaj cov khoom siv microbial, thiab dhau ntawm cov khoom siv raw, tau nws cov khoom noj khoom haus lossis lwm yam tshuaj ntsig. Piv txwv li, Simvastatin yog HMG CO Reductase inhibitor tau los ntawm syni synthesis ntawm nyiam. Txoj kev no tuaj yeem siv cov tsiaj ntawv ua kom tiav cov khoom lag luam ntuj thiab txhim kho kev ua si, kev ruaj khov, lossis cov khoom siv tshuaj ntawm cov tshuaj los ntawm kev hloov kho tshuaj lom neeg.
3. Tag Nrho Cov Qauv Synthesis
Txawm hais tias tag nrho cov synthesis txoj kev ntawm pajtastati nws tus kheej tej zaum yuav yog qhov sib txawv thiab kim, tag nrho cov hluavtaws zoo thiab muaj tswv yim rau cov tshuaj. Los ntawm kev tsim kho lub synthesis tsim nyog, cov sib xyaw nrog cov txheej txheem nyuaj uas nyuaj rau kev ua haujlwm lossis cov qauv sightthetic tuaj yeem npaj tau. Txawm li cas los xij, rau cov neeg nyiam nkauj, vim nws cov khoom muaj ntau yam thiab yooj yim los ntawm cov microbial fermentation, tag nrho cov hluavtaws yuav tsis muaj nyob hauv cov ntawv thov siv.
Cov txheej txheem sib xws rau kev npaj womastati tsuas yog suav nrog kev ua kom muaj microbial fermentation, syni synthesis, thiab tag nrho cov synthesis. Ntawm lawv, microbial fermentation tau dhau los ua cov txheej txheem tseem ceeb rau kev tsim cov txiv neej nyiam ua vim nws cov txiaj ntsig ntawm tus nqi qis thiab ib puag ncig ua phooj ywg; Txoj kev sighthetic muab txoj kev tseem ceeb rau kev npaj ntawm derivatives ntawm txiv neej; Tag nrho cov qauv hluav taws xob muab ntau yam thiab cov kev xaiv rau cov kws kho mob tshuaj. Nws yuav tsum raug sau tseg tias nrog kev txhim kho kev tshawb fawb txuas ntxiv thiab thev naus laus zis thiab cov cuab yeej siv hluavtaws tshiab tseem yuav txhim kho thiab zoo tag nrho yav tom ntej.
Txiv nyiamYog lipid -} kev siv tshuaj uas tseem ceeb tshaj plaws nws kho cov nyhuv endogenous cholesterol synthesis. Nws lub ntsiab ua haujlwm suav nrog:
1. Txo cov ntshav lipids:
Nws tuaj yeem sib tw tus nqi txwv cov enzymethylgutyllutenyl Npuas Cynthesis, yog txo cov roj chopthester thiab tsawg {{1} {}} las lipoprotein Cov roj (cholesterol) hauv cov ntshav dej.
2. Kev tiv thaiv thiab kev kho mob atherosclerosis thiab mob plawv plawv:
Vim tias nws tuaj yeem txo cov ntshav lipids, nws pab tswj cov quav hniav, thiab yog li ua tus mob hlwb ntawm atherosclerosis, thiab yog li ua rau mob plawv, thiab yog li mob plawv hiav txwv, thiab kev sib cav sib ceg.
3. Txo cov ntshav siab tshaj plaws cov qib thiab nce ntshav siab -} cov roj lipoprotein ntau ntxiv:
Ntxiv rau kev txo cov roj (cholesterol)
Txiv nyiamUa haujlwm los ntawm kev ua haujlwm endogenous anglesterical synthesis, inhibiting lipant fatterol, inhibiting heptic fatty acid synthesis, thiab inhibiting} ntev lipoprotein oxidative kev hloov kho. Cov tshuaj no tuaj yeem siv rau kev kho mob ntawm cov kab mob xws li hyperchaolesterolemia thiab sib xyaw hyperlipidemia.
1. Inhibit endogenous cholesterol synthesis
Los ntawm kev sib tw inhibling hydroxyglutaryl- coa reeterase, yog li hloov acirounds acid yog txo, yog li iniblitous cholesterol synthesis. Cov tshuaj no tuaj yeem txo cov ntshav roj (cholesterol) thiab cov roj cholesterol)
2. Txo cov synthesis ntawm tsawg heev-} cov roj cholesterol
Nws tuaj yeem nce tus naj npawb thiab kev ua si ntawm LDL receptors rau ntawm lub cell saum npoo, thiab li cov ntsiab lus ntawm cov roj cholesterol tsawg hauv cov ntshav. Cov neeg mob tuaj yeem siv cov khoom lag luam no rau cov kev khomob raws li cov lus qhia kho mob, tab sis saib xyuas yuav tsum tau them nyiaj rau daim siab ua haujlwm kom tsis txhob muaj kev tsis xis nyob.
3. Txhawb kom lub neej sib tawg ntawm qis -} lasprotein
Nws tuaj yeem txhim kho LDL Souper Foldiated LDL thiab catabolism ntawm lub cell saum npoo av, pab kom txo cov roj av qis ntawm cov roj ntsha roj hauv ntshav ntshav. Rau cov neeg mob uas tau nce qis - cov lipoprotein, cov kws kho mob yuav txiav txim siab ua cov tshuaj no los txhim kho qib ntshav lipid. Thaum lub sij hawm noj tshuaj, yuav tsum tau kuaj xyuas cov kev kuaj ib txwm yuav tsum tau ua raws li cov ntsuas hluav taws xws li ntshav lipps thiab lub siab ua haujlwm.
4. Inhibit hepatic fatty acid synthesis
Nws tuaj yeem downregulate qhov kev qhia ntawm steroid cov kev cai txua brectatory srecp-1c, yog li txo cov cuab yeej fatty acids hauv lub siab. SREBP-1C yog qhov tseem ceeb Molecule tswj kev ua rog roj fatty acid synthesis, thiab nws cov kab qis ua rau txo qis fatty acid synthesis, uas tau txais txiaj ntsig rau daim siab. Yog li, nws tuaj yeem siv los kho hyperlipidemia, atherosclerosis thiab lwm yam kab mob.
5. Inhibit inacellular low -} cov lipoprotein oxidation hloov kho
Muaj cov khoom siv antioxidant, tuaj yeem tiv thaiv kev hloov oxidative ntawm tsawg {{0} Kev tiv thaiv nws cov kab mob oxidation, yog li tiv thaiv kev tiv thaiv oxidhodiological. Thaum tsom cov neeg tshwj xeeb, nws yog qhov tsim nyog los kho cov tshuaj lossis ntsuas tshwj xeeb kom muaj kev nyab xeeb thiab ua haujlwm zoo. Piv txwv li, cov neeg mob laus lossis cov uas muaj lub npe tsis txaus yuav tsum ceev faj thaum siv nws, thiab lawv muaj nuj nqi ntxiv yuav tsum raug ntsuas tas li.
Hypercholesterolememia yuav ua rau atherosclerotic, thiab tom qab ntawd ua rau atherosclerosis, kab mob plawv thiab ib qho kab mob plawv thiab kab mob sib txawv xws li myocardial infarction thiab cerebral infarction. Qhov nce hauv cov roj cholesterol ntau hauv cov ntshav, tshwj xeeb tshaj yog cov roj cholesterol (LDL}} C)
Biosynthesis ntawm tib neeg cov roj cholesterol yog ze li 30 kauj ruam cov txheej txheem, nyob rau hauv lub HMG COA yog tus nqi txwv cov enzyme uas tswj cov roj synthesis. Los ntawm inhibling hmov reductase, cholesterol biosynthesis tuaj yeem tiv thaiv, yog li txo cov qib roj cholesterol hauv tib neeg lub cev.
Japana tus kws tshawb fawb Endess endo merkira tau cais cov paj huam sib raug zoo tso tawm Inhibalostatin los ntawm Aspergillus Niger Niger. Txawm li cas los xij, kev sim tshuaj xyuas ntawm Mevalonate tau txiav tawm vim nws cov kuab lom rau txoj hnyuv lymphoma.
Alfred Alberts thiab nws pab neeg los ntawm Merck nrhiav tau zoo HMG CO-reductase insibitor los ntawm asibritores niger inhibitores niger in alicitation broth hauv av thiab npe hu ua poj niam.
Zhang endo tau txais HMG CO Reductase inhibitor thiab npe ntawm nws Monacolin K. Nws yog tib qho sib txuas ua ke. Tom qab ntau tshaj 7 xyoo ntawm kev sim tshuaj mob, kev nyab xeeb thiab ua tau zoo ntawm kev hlubati tau nkag siab tau.
Merck daim ntawv thov rau lovastati tau pom zoo los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj (FDA), dhau los ua thawj cov lag luam tshuaj. Tom qab, cov "statins" tau qhia, muab ntau cov tshuaj muaj txiaj ntsig rau cov kev cai tswj cov roj cholesoles.
Statins yog lub npe hu ua "penicillin ntawm lipid -}} kev tshawb fawb thiab kev tshawb fawb tseem ceeb tshaj plaws hauv kev tshawb fawb ntawm xyoo pua 20th.
Kev tsim muaj ntawm Libastati yog ib tug txheej txheem ntev los ntawm kev tshawb nrhiav kev tshawb pom kev tsim kho tshuaj. Dr. Sachel Punpan, tus Biochemist ntawm National Institutes of Health (NIH) uas tau ua lub hauv paus rau qhov no rau tib neeg kev noj qab haus huv. Lub New York Time Luam tawm Alitishush rau Lub Xya Hli Tim 37), tus kws tsim khoom ntawm lub hnub nyoog ntawm lub hnub nyoog ntawm lub hnub nyoog ntawm lub hnub nyoog ntawm lub hnub nyoog 87. Nws mob siab ntev dua peb caug xyoo thiab tsim cov roj (cholesteroleslivol thawj zaug txo cov tshuaj, ntxim nyiam. Nws tsis kam ua rau nws tus kheej sau nws lub npe me me, tab sis thaum tus thawj coj ntawm cov kws kho mob tau tshaj tawm, lawv tau muab nws tus thawj coj hauv tebchaws Asmeskas txoj cai {{14 {}} Tes tes, thiab peb tau paub ib leeg rau 60 xyoo, ze li cov kwv tij. Nyob rau hauv ntau cov ntaub ntawv, Vajleros teev alberts raws li ib tug co-sau, tab sis hais txog cov kev sau rau txiv neej ntawm kev hlubati, vajeros ntseeg hais tias "txiv nyiamtau nrhiav tau Alberts
Kev Xav Ua Lag Luam Xav Kev Loj Hlob
Hypercholesterolemia yog ib qho kabmob ib txwm muaj uas cuam tshuam ntau tus neeg thoob ntiaj teb. Nrog kev txhim kho ntawm tib neeg cov qauv nyob, tsis zoo ua neej thiab kev noj mov tsis zoo thiab muaj ntau yam, ua rau muaj kev nce siab ntawm hypercholes. Qhov no muab kev ua lag luam loj heev rau xws lipid -} kev siv tshuaj. Tus kab mob plawv yog ib qho kev noj qab haus huv ntawm kev noj qab haus huv thoob ntiaj teb, thiab qhov tshwm sim yog cuam tshuam nrog cov roj cholesterol siab. Nws tuaj yeem txo qhov kev pheej hmoo ntawm cov kab mob plawv los ntawm kev txo qis ntawm cov roj qis qis- cov roj cholesterol (LDL}} c) hauv cov ntshav. Yog li ntawd, nws muaj cov ntawv thov tseem ceeb hauv kev tiv thaiv thiab kho cov kab mob plawv.
Qhov tseem ceeb tshuaj yeeb
Nws yog ib lub hydroxylethylluta monooryl Coa (HMG COA) REDITE inhibitory uas inhobes roj synthesis thiab txo cov roj (cholesterolular cholesterolular. Qhov kev siv tshuab no ua rau kev nyiam nyiam kev txo qis cov ntshav lipids txo qis. Ntxiv rau kev txo cov ntshav lipids txo nws kuj tseem tuaj yeem txhim kho cov haujlwm endothelial, enos), thiab nce cov synthesis thiab tso cov nitric oxide (tsis muaj). Qhov no pab tswj cov roj ntsha licular nruj, thim rov qab hypoxia indicter vasoconstriction thiab txoj kev hloov pauv. Nws tseem muaj anti -} polmidatory ntawm lub hlwb mespiferatation, uas tuaj yeem ua tiav lub hom phiaj txo lub hom phiaj. Cov Pharmacological hloov tshiab ntxiv txhim kho lawv tus nqi hauv cov ntawv thov kev kho mob.
Kev sib tw ua lag luam thiab cov cib fim
Txawm hais tias qhov kev ntaus lag luam dav, kev sib tw ua lag luam kuj yog hnyav heev. Ntau lub tuam txhab kws tshuaj ntawm cov tuam txhab uas tau ua rau cov tub yees li qub, uas yuav tsum muaj lawv cov tuam txhab tsim khoom, thiab lwm yam kev lag luam lag luam, thiab lwm yam kom muaj txiaj ntsig kev sib tw. Ntsib nrog kev sib tw ua lag luam ua lag luam muaj peev xwm teb tau cov kev cov nyom los ntawm kev tawm dag zog los ntawm kev nrhiav chaw zoo los ntawm kev nthuav dav ntxiv, txhim kho cov khoom lag luam zoo, thiab nthuav cov khoom muag. Lub caij no, nrog rau kev paub ntxiv ntawm kev noj qab haus huv thiab kev ua lag luam txuas ntxiv ntawm kev kho mob thev naus laus zis, kev lag luam qis dua, nqa cov hauv kev lag luam txhim kho.
Kev tsim kho yav tom ntej
Nrog kev nce qib nro ntawm science thiab thev naus laus zis, nws cov lus qhia yav tom ntej yuav suav nrog kev txhim kho cov qauv tshuaj txhim kho, txhim kho cov kev mob tshwm sim, thiab lwm yam. Nyob rau tib lub sijhawm, nws kuj tseem tuaj yeem tshawb xyuas nws cov ntawv thov sib txuas nrog lwm cov lipid {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} kev ua haujlwm ntawm kev kho cov kab mob plawv. Nrog rau kev nrawm nrawm ntawm kev thoob ntiaj teb thiab kev txhim kho kev lag luam thoob ntiaj teb, kev ua lag luam rau xws li lipid {}}} Cov tshuaj qis dua yuav txuas ntxiv. Nyob rau hauv lub neej tom ntej, nws cov chaw tsim khoom lag luam tuaj yeem nquag tshawb xyuas thoob ntiaj teb kev lag luam ntawm lawv cov khoom.
Lovastatin, ib tug tho kev statin, piv txwv li kev hloov pauv ntawm ib qho - Lub hom phiaj tshuaj rau ntau hom tshuaj rau ntau yam tshuaj. Thaum nws lub luag haujlwm hauv kev tshawb fawb plawv tseem ceeb, tawm cov kev tshawb fawb tshwm sim nws lub peev xwm hauv neurology, oncology, thiab kis cov kab mob.
Cim npe nrov: Lovastatin CAS 75330-75-5, Cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, nqe, loj, rau muag