Ketoconazole ntsiav tshuaj 100 mg, cov khoom xyaw tseem ceeb yog ketoconazole, nrog rau cov tshuaj npe 1-acetyl-4- [4- [2- (2,4-dichlorophenyl) -2- (1H-imidazol-1-methyl) -1,3-dioxolane-4-methoxy] phenyl] piperazine. Nws cov mis molecular yog C26H28Cl2N4O4, nrog rau qhov hnyav molecular ntawm 531.44. Ketoconazole ntsiav tshuaj feem ntau yog cov ntsiav tshuaj dawb nrog qhov tshwj xeeb ntawm 0.2 grams ib ntsiav tshuaj. Raws li tus neeg sawv cev imidazole broad-spectrum antifungal tshuaj, nws tau ua lub luag haujlwm tseem ceeb hauv kev kho mob, tab sis nws kuj tau nyiam ntau yam vim muaj kev pheej hmoo.
Ketoconazole feem ntau tshwm sim raws li ib tug dawb mus rau dawb crystalline hmoov, tsw ntxhiab los yog nrog ib tug tsis muaj zog tsw. Nws siv lead ua morphology tsis tu ncua, kev ntxhib los mos yog qhov muag heev, thiab cov qauv siv lead ua tuaj yeem pom nyob rau hauv lub tshuab tsom. Cov tsos mob no yog ze ze rau nws cov qauv tshuaj. Lub nplhaib imidazole, dioxane nplhaib, benzene nplhaib thiab lwm yam khoom siv uas muaj nyob rau hauv ketoconazole molecules tsim cov qauv siv lead ua ruaj khov los ntawm covalent bonds thiab intermolecular rog.
Lub morphology ntawm crystalline hmoov tsis tsuas yog cuam tshuam rau purity nrhiav kom tau cov tshuaj, tab sis kuj yog ze ze rau cov txheej txheem npaj thiab tshuaj tso tawm yam ntxwv ntawm formulation. Piv txwv li, nyob rau hauv cov tshuaj pleev ib ce, lub crystalline morphology ntawm ketoconazole yuav cuam tshuam nws dispersion uniformity nyob rau hauv lub matrix, yog li cuam tshuam rau cov tshuaj nkag mus efficiency ntawm daim tawv nqaij.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Ketoconazole hmoov | Ketoconazole Table |
| Yam khoom | Hmoov | Rooj |
| Khoom Purity | HPLC Ntau dua lossis sib npaug rau 99.0% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | 100g / 1kg / thiab lwm yam. | Customizable |
| Pob khoom | PE / Al foil hnab / ntawv lub thawv rau Pure hmoov |
100 ntsiav tshuaj / lub raj mis 80 fwj / thawv |
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Ketoconazole +. COA
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Certificate of Analysis |
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Compound npe |
Ketoconazole | |
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CAS Nr. |
65277-42-1 | |
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Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2028 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
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Ib leeg impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Pharmacological mechanism thiab antibacterial spectrum
Ketoconazole ntsiav tshuaj 100 mgexerts antifungal teebmeem los ntawm ntau yam mechanisms. Cov txheej txheem tseem ceeb yog cuam tshuam nrog kev ua haujlwm ntawm fungal cytochrome P-450, yog li inhibiting biosynthesis ntawm ergosterol, lub ntsiab sterol ntawm cov kab mob fungal. Cov txheej txheem no tsis tsuas yog ua rau cov qauv ntawm cov kab mob fungal ntawm tes, tab sis kuj hloov lawv cov permeability, uas ua rau cov dej ntws ntawm cov khoom tseem ceeb hauv lub cev. Tsis tas li ntawd, ketoconazole tuaj yeem cuam tshuam cov biosynthesis ntawm fungal triglycerides thiab phospholipids, nrog rau kev ua haujlwm ntawm oxidases thiab peroxidases, uas ua rau cov tsub zuj zuj ntawm hydrogen peroxide hauv hlwb, thaum kawg ua rau cellular microstructural degeneration thiab cell necrosis.
Ketoconazole muaj qhov dav -spectrum antibacterial kev ua haujlwm thiab muaj txiaj ntsig zoo tiv thaiv ntau yam sib sib zog nqus- zaum thiab sab saum toj fungi. Tshwj xeeb tshaj yog, nws muaj cov kab mob tua kab mob tawm tsam sib sib zog nqus-cov kab mob fungi xws li Candida, Chromogenic Fungi, Sphingosporum, Histoplasma, thiab Sporothrix, nrog rau cov kab mob ntawm cov kab mob xws li Trichophyton. Txawm li cas los xij, ketoconazole muaj qhov cuam tshuam tsis zoo rau cov kab mob xws li Aspergillus, Burkholderia sporogenes, qee cov xim tsaus nti, thiab Mucor genus. Qhov dav spectrum ntawm cov tshuaj tua kab mob no ua rau ketoconazole muaj txiaj ntsig zoo rau kev kho mob ntawm ntau yam kab mob fungal.
Clinical daim ntawv thov thiab indications
Ketoconazole tau siv dav hauv kev kho mob, npog kev kho mob ntawm ntau yam kab mob fungal thiab kab mob ntawm daim tawv nqaij fungal.
(1) Cov kab mob fungal
Candidiasis: nrog rau cov kab mob ntawm daim tawv nqaij thiab cov mucosal candidiasis, qhov ncauj candidiasis, urinary tract candidiasis, thiab lwm yam. Ketoconazole kuj tau qhia cov txiaj ntsig zoo rau kev kho mob ntev thiab rov tshwm sim ntawm qhov chaw mos candidiasis uas tsis muaj txiaj ntsig hauv kev kho mob hauv zos.
Cov kab mob sib sib zog nqus fungal: xws li dermatitis blastomycosis, coccidiomycosis, cov ntaub so ntswg cytoplasmic mycosis, chromogenic mycosis, para coccidiomycosis, thiab lwm yam. Cov kab mob no feem ntau tshwm sim los ntawm qhov tob -siv fungi thiab nyuaj kho. Ketoconazole, raws li cov tshuaj tiv thaiv kab mob zoo, muab cov kev xaiv tshiab rau kev kho cov kab mob no.
(2) kab mob ntawm daim tawv nqaij fungal
Cov kab mob fungal superficial: xws li tinea pedis, tinea pedis, tinea corporis, tinea crus, pityriasis versicolor, thiab lwm yam. Cov kab mob no yog tshwm sim los ntawm daim tawv nqaij fungi thiab poov xab, manifested raws li cov tsos mob xws li khaus, liab, thiab flaking ntawm daim tawv nqaij. Ketoconazole zoo alleviates cov tsos mob no los ntawm inhibiting fungal kev loj hlob thiab kev loj hlob.
Cov kab mob tawv nqaij tawv tawv: Ketoconazole tuaj yeem siv los ua kev kho mob rau cov kab mob tawv nqaij tawv tawv uas tsis muaj txiaj ntsig nrog kev kho mob hauv zos lossis kev tswj hwm qhov ncauj ntawm oxytetracycline, lossis nyuaj rau kev kho mob oxytetracycline.
Ntxiv rau,Ketoconazole ntsiav tshuaj 100 mgKuj tseem siv tau los kho thiab tswj cov dandruff thiab lwm yam desquamation, scaling, khaus, nrog rau seborrheic dermatitis thiab lwm yam kab mob. Txawm hais tias cov kab mob no tsis yog cov kab mob fungal, ketoconazole kuj tuaj yeem txo cov tsos mob ntawm qee qhov los ntawm nws cov tshuaj tiv thaiv - mob thiab tiv thaiv kab mob.
Cov tshuaj tiv thaiv tsis zoo thiab saib xyuas kev pheej hmoo
Ketoconazole tuaj yeem ua rau muaj kev phiv ntau yam thaum lub sijhawm kho thiab yuav tsum tau saib xyuas thiab kho raws sijhawm.
(1) Hepatotoxicity
Hepatotoxicity yog ib qho kev phiv loj tshaj plaws ntawm ketoconazole. Nws tuaj yeem ua rau muaj kev nce hauv cov ntshav aminotransferase, tshwm sim raws li cov tsos mob xws li jaundice, zis xim tsaus, thiab qaug zog txawv txav. Qhov tshwm sim ntawm hepatotoxicity yog kwv yees li 0.01%, tab sis thaum nws tshwm sim, qhov tshwm sim tuaj yeem loj heev, thiab txawm tias muaj neeg tuag tau raug tshaj tawm. Kab mob siab xws li mob tshwm sim hauv cov menyuam yaus. Yog li ntawd, ua ntej siv ketoconazole, cov neeg mob yuav tsum tau kuaj xyuas lub siab ua haujlwm thiab saib xyuas lub siab ua haujlwm tsis tu ncua thaum kho. Yog tias pom qhov txawv txav ntawm daim siab ua haujlwm, cov tshuaj yuav tsum raug tso tseg raws sijhawm thiab yuav tsum tau siv cov kev kho mob sib xws.
(2) Cov tshuaj tiv thaiv kab mob plab
Cov kab mob hauv plab yog ib qho kev tsis zoo ntawm ketoconazole, tshwm sim raws li xeev siab, ntuav, tsis qab los noj mov, mob plab, raws plab, plab zom mov thiab lwm yam tsos mob. Cov tsos mob no feem ntau yog mob me thiab tuaj yeem kho tus kheej tom qab txiav tshuaj. Tab sis rau cov neeg mob uas muaj cov tsos mob hnyav, kev kho mob tuaj yeem muab tau, xws li kev siv tshuaj antiemetic, tshuaj tiv thaiv kab mob plab, thiab lwm yam.
(3) Endocrine system teb
Ketoconazole tuaj yeem cuam tshuam cov synthesis ntawm testosterone thiab adrenal cortex cov tshuaj hormones, ua rau cov kab mob endocrine cuam tshuam xws li kev loj hlob ntawm lub mis thiab cov phev tsis muaj zog hauv cov txiv neej. Cov tshuaj tiv thaiv no feem ntau maj mam rov qab los tom qab tsis siv tshuaj, tab sis rau cov neeg mob uas muaj cov tsos mob hnyav, kev kho endocrine yuav tsim nyog.
(4) tawv nqaij khaus
Thaum siv cov tshuaj ketoconazole, tej zaum yuav muaj qhov kub hnyiab thiab khaus khaus ntawm daim tawv nqaij ntawm qhov chaw tshuaj, thiab qee qhov yuav muaj cov tsos mob ntawm daim tawv nqaij xws li hu rau dermatitis. Cov tsos mob no feem ntau yog mob me thiab tuaj yeem kho tus kheej tom qab txiav tshuaj. Tab sis rau cov neeg mob uas muaj cov tsos mob hnyav, tshuaj tiv thaiv hauv zos - mob thiab tshuaj tiv thaiv tsis haum tuaj yeem muab.
(5) Lwm yam tsis zoo tshwm sim
Ketoconazole kuj tseem tuaj yeem ua rau lwm yam kev phiv xws li pob khaus, kiv taub hau, tsaug zog, thiab photophobia. Qhov tshwm sim ntawm cov kev cuam tshuam tsis zoo no kuj tsawg, tab sis thaum lawv tshwm sim, lawv kuj yuav tsum tau kho tam sim ntawd.
Kev sib cuam tshuam tshuaj thiab kev nyab xeeb ntawm tshuaj
Ketoconazole cuam tshuam nrog ntau yam tshuaj, uas yuav cuam tshuam rau kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj.
(1) Kev sib cuam tshuam nrog cov tshuaj anticoagulant
Thaum ketoconazole siv ua ke nrog cov tshuaj tiv thaiv coagulants xws li warfarin, coumarin, thiab indanedione derivatives, nws cov nyhuv tuaj yeem txhim kho, ua rau lub sij hawm ntev prothrombin. Yog li ntawd, thaum lub sij hawm siv ntawm ketoconazole, yog hais tias yuav tsum tau siv anticoagulants ib txhij, tus neeg mob lub coagulation muaj nuj nqi yuav tsum tau nyob ze saib xyuas, thiab npaum li cas ntawm anticoagulants yuav tsum tau kho raws li lub sij hawm prothrombin.
(2) Kev sib cuam tshuam nrog Cyclosporine
Thaum siv cyclosporine thiab ketoconazole ib txhij, cov ntshav siab ntawm cov qub tuaj yeem nce ntxiv, thiab kev pheej hmoo ntawm nephrotoxicity kuj tseem tuaj yeem nce ntxiv. Yog li, thaum siv ketoconazole, yog tias cyclosporine yuav tsum tau siv ib txhij, cov ntshav siab ntawm cyclosporine yuav tsum tau saib xyuas, thiab cov koob tshuaj cyclosporine yuav tsum raug kho raws li kev soj ntsuam xyuas.
(3) Kev sib cuam tshuam nrog acid ua tshuaj, thiab lwm yam
Thaum siv cov tshuaj antacids, tshuaj anticholinergic, antispasmodics, histamine H2 receptor blockers, omeprazole, sucralfate, thiab lwm yam.Ketoconazole ntsiav tshuaj 100 mgtuaj yeem txo qis. Yog li, cov tshuaj no yuav tsum tau muab 2 teev tom qab noj cov tshuaj ketoconazole kom tsis txhob muaj kev cuam tshuam ntawm cov tshuaj.
(4) Kev sib cuam tshuam nrog lwm yam tshuaj
Ketoconazole kuj tuaj yeem cuam tshuam nrog ntau yam tshuaj xws li tshuaj tiv thaiv arrhythmic, tshuaj tiv thaiv kev ntxhov siab, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj hypoglycemic. Yog li ntawd, ua ntej siv ketoconazole, cov neeg mob yuav tsum qhia lawv tus kws kho mob txog lwm yam tshuaj uas lawv tab tom noj. Cov kws kho mob yuav tshuaj xyuas qhov kev pheej hmoo ntawm kev sib cuam tshuam tshuaj raws li qhov xwm txheej tshwj xeeb thiab kho cov phiaj xwm tshuaj raws li.
Ketoconazole ntsiav tshuaj yog ib tug muaj zog antifungal tus neeg sawv cev nrog ib tug zoo-tsim lub luag hauj lwm nyob rau hauv kev kho mob ntawm cov kab mob loj mycoses thiab refractory superficial kab mob. Thaum lawv cov kev siv tau poob qis nrog qhov tshwm sim ntawm kev nyab xeeb dua, lawv tseem yog qhov kev xaiv kho mob tseem ceeb hauv cov xwm txheej tshwj xeeb. Cov kws kho mob yuav tsum ntsuas cov txiaj ntsig muaj txiaj ntsig tiv thaiv kev pheej hmoo ntawm hepatotoxicity, kev cuam tshuam ntawm endocrine, thiab kev sib cuam tshuam ntawm cov tshuaj thaum muab cov ntsiav tshuaj ketoconazole. Kev soj ntsuam ze ntawm daim siab ua haujlwm, qhov xwm txheej ntawm adrenal, thiab lub plawv tsis ua haujlwm yog qhov tseem ceeb los xyuas kom muaj kev nyab xeeb thiab muaj txiaj ntsig zoo. Raws li kev tshawb fawb txuas ntxiv mus nthuav tawm cov ntawv thov tshiab, ketoconazole tuaj yeem pom qhov cuam tshuam txuas ntxiv hauv kev tswj hwm cov kab mob fungal thiab cov tshuaj hormones- nyob ntawm cov kab mob malignancies.
Nws tseem yog ib qho kev xaiv tseem ceeb rau kev tswj xyuas cov kab mob loj heev thiab cov kab mob refractory superficial fungal, tshwj xeeb tshaj yog nyob rau hauv qhov chaw uas lwm txoj kev kho mob tsis muaj. Txawm li cas los xij, lawv txoj kev siv yog txwv los ntawm qhov tseem ceeb ntawm hepatotoxicity, endocrine cuam tshuam, thiab kev sib cuam tshuam ntawm cov tshuaj, yuav tsum tau ua raws li cov lus qhia nruj me ntsis thiab kev saib xyuas ze. Cov kws kho mob yuav tsum ntsuas cov txiaj ntsig muaj peev xwm tiv thaiv kev pheej hmoo thiab xav txog lwm txoj hauv kev nyab xeeb thaum twg los tau. Raws li kev kho tshuaj tiv thaiv kab mob txuas ntxiv mus, ketoconazole lub luag haujlwm yuav txo qis ntxiv, tshwj tseg rau cov xwm txheej uas nws cov khoom tshwj xeeb muaj qhov zoo sib xws.
Cov lus nug nquag
Dab tsi yog qhov txaus ntshai ntawm ketoconazole?
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Ketoconazoletej zaum yuav ua rau lub siab puas tsuaj, tej zaum hnyav txaus yuav tsum tau hloov lub siab los yog ua rau tuag. Kev puas siab puas ntsws tuaj yeem tshwm sim hauv cov neeg uas tsis tau muaj kab mob siab lossis lwm yam mob uas ua rau muaj kev pheej hmoo tias lawv yuav ua rau lub siab puas tsuaj.
Puas yog ketoconazole zoo rau daim tawv nqaij?
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Yog koj siv ntau dhau. Yog tias koj siv tshuaj zawv plaub hau los yog ketoconazole ntau dhau lawm, lossis siv nws ntau dua li qhov koj xav tau,nws tuaj yeem ua rau koj cov tawv nqaij khaus lossis liab, txawm tias qhov liab liab yuav tsis pom tseeb ntawm cov tawv nqaij xim av lossis xim dub.
Ketoconazole ua haujlwm sai npaum li cas?
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Ketoconazole cream thiab tshuaj zawv plaub hau feem ntau noj2 mus rau 4 hnubua hauj lwm rau dandruff, scaly thiab qhuav los yog greasy ntawm daim tawv nqaij (seborrhoeic dermatitis), jock khaus thiab hws tawm pob. Cov kis las ko taw thiab qee yam kab mob ntawm daim tawv nqaij tuaj yeem siv sijhawm txog 6 lub lis piam kom zoo dua.
Koj tso ketoconazole rau ntawm daim tawv nqaij ntev npaum li cas?
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ntub daim tawv nqaij thiab siv cov tshuaj rau tej qhov chaw kom huv si. Massage maj mam mus rau hauv daim tawv nqaij ua hauj lwm nws mus rau hauv ib tug tag nrho lather. Tawm hauv qhov chaw rau5 feeb.
Cim npe nrov: Ketoconazole ntsiav tshuaj 100 mg, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom